CL2016001578A1 - Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c. - Google Patents

Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c.

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Publication number
CL2016001578A1
CL2016001578A1 CL2016001578A CL2016001578A CL2016001578A1 CL 2016001578 A1 CL2016001578 A1 CL 2016001578A1 CL 2016001578 A CL2016001578 A CL 2016001578A CL 2016001578 A CL2016001578 A CL 2016001578A CL 2016001578 A1 CL2016001578 A1 CL 2016001578A1
Authority
CL
Chile
Prior art keywords
adenoreceptors
antagonists
alpha
piperidinyltetrahydroquinolines
substituted
Prior art date
Application number
CL2016001578A
Other languages
English (en)
Inventor
Carsten Schmeck
Gorden Redlich
Andreas Knorr
Frank Wunder
Philipp Buchgraber
Eva Maria Becker-Pelster
Volker Geib
Anja Buchmüller
Andreas Göller
Herbert Himmel
Raimund Kast
Dieter Lang
Hanna Tinel
Karen Engel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CL2016001578A1 publication Critical patent/CL2016001578A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Public Health (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
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  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
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Abstract

COMPUESTOS DERIVADOS DE PIPERIDINILTETRAHIDROQUINOLINAS SUSTITUIDAS Y SU USO COMO ANTAGONISTAS DE LOS ADENORECEPTORES ALPHA-2C; PROCESO PARA SU PREPARACION; MEDICAMENTO QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO Y/O PROFILAXIS DE FORMAS PRIMARIAS Y SEDUNDARIAS DE MICROANGIOPATIAS DIABETICAS, FALLA CARDIACA DIABETICA, TRASTORNOS DE LA CIRCULACION PERIFERICA, FENOMENO DE RAYNAUD, SINDROME DE CREST, NEUROPATIAS PERIFERICAS, ENTRE OTRAS.
CL2016001578A 2013-12-19 2016-06-17 Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c. CL2016001578A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198385 2013-12-19
EP14192877 2014-11-12

Publications (1)

Publication Number Publication Date
CL2016001578A1 true CL2016001578A1 (es) 2017-01-13

Family

ID=52101341

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001578A CL2016001578A1 (es) 2013-12-19 2016-06-17 Piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c.

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US (3) US9944621B2 (es)
EP (2) EP3329920A3 (es)
JP (2) JP6487922B2 (es)
KR (1) KR20160098425A (es)
CN (1) CN106458978B (es)
AP (1) AP2016009276A0 (es)
AU (2) AU2014364732B2 (es)
BR (1) BR112016014008A2 (es)
CA (1) CA2934108C (es)
CL (1) CL2016001578A1 (es)
CR (1) CR20160276A (es)
CU (1) CU24390B1 (es)
CY (1) CY1120701T1 (es)
DK (1) DK3083592T3 (es)
DO (1) DOP2016000149A (es)
EA (1) EA032250B1 (es)
ES (1) ES2689023T3 (es)
HR (1) HRP20181536T1 (es)
HU (1) HUE039942T2 (es)
IL (1) IL246246B (es)
JO (2) JOP20200052A1 (es)
LT (1) LT3083592T (es)
MX (1) MX365289B (es)
MY (1) MY177393A (es)
NI (1) NI201600084A (es)
NZ (2) NZ721374A (es)
PE (1) PE20160846A1 (es)
PH (1) PH12016501190B1 (es)
PL (1) PL3083592T3 (es)
PT (1) PT3083592T (es)
RS (1) RS57835B1 (es)
SG (1) SG11201604978QA (es)
SI (1) SI3083592T1 (es)
TN (1) TN2016000250A1 (es)
TW (1) TWI667234B (es)
UA (1) UA120702C2 (es)
UY (1) UY35887A (es)
WO (1) WO2015091414A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
US20190008867A1 (en) 2015-11-13 2019-01-10 Ph Pharma Co., Ltd. 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
EP3615031A1 (en) 2017-04-27 2020-03-04 Bayer Aktiengesellschaft Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
CN110917195A (zh) * 2018-08-20 2020-03-27 山西惠尔健生物科技有限公司 肌松剂阿库氯铵（Alcuronium chloride）可作为抗心律失常药物
US20220016113A1 (en) * 2018-11-20 2022-01-20 Bayer Aktiengesellschaft ?2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea
WO2020165031A1 (de) 2019-02-15 2020-08-20 Bayer Aktiengesellschaft Substituierte isochinolin-piperidinylmethanon-derivate
WO2020182018A1 (zh) * 2019-03-12 2020-09-17 四川科伦博泰生物医药股份有限公司 氮杂环化合物、其制备方法及用途
WO2022135335A1 (zh) * 2020-12-21 2022-06-30 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022826A1 (en) 1993-04-07 1994-10-13 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
CA2241567A1 (en) 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
JP2001510195A (ja) 1997-07-16 2001-07-31 ノボ ノルディスク アクティーゼルスカブ 縮合化１，２，４−チアジアジン誘導体、その調製及び使用
DE19734557A1 (de) 1997-08-04 1999-02-11 Oliver Lang Netzanschlußloses Kleinleistungs-Haushaltsgerät
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
UA69420C2 (uk) 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
ES2246233T3 (es) 1999-05-04 2006-02-16 Schering Corporation Derivados de piperidina utiles como antagonistas de ccr5.
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
FI20000480A0 (fi) * 2000-03-01 2000-03-01 Orion Yhtymae Oyj Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
US6444681B1 (en) 2000-06-09 2002-09-03 The Ohio State University Research Foundation Methods and compositions for treating Raynaud's Phenomenon and scleroderma
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
GB0108876D0 (en) 2001-04-09 2001-05-30 Novartis Ag Organic Compounds
AR036366A1 (es) 2001-08-29 2004-09-01 Schering Corp Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit
CA2430328A1 (en) * 2001-09-28 2003-04-10 Kyowa Hakko Kogyo Co., Ltd. Receptor antagonist
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2004067513A1 (en) * 2003-01-27 2004-08-12 Oy Juvantia Pharma Ltd Antagonists for alpha-2 adrenoceptors
CA2544377A1 (en) 2003-11-03 2005-05-12 Schering Corporation Bipiperidinyl derivatives useful as inhibitors of chemokine receptors
GB0326992D0 (en) 2003-11-20 2003-12-24 Dawson Philip J Valve control system
CA2554465A1 (en) 2004-02-05 2005-08-25 Schering Corporation Piperidine derivatives useful as ccr3 antagonists
EP1868605A2 (en) 2005-03-31 2007-12-26 Janssen Pharmaceutica, N.V. Phenyl and pyridyl lta4h modulators
US7700592B2 (en) * 2005-08-25 2010-04-20 Schering Corporation α2C adrenoreceptor agonists
CA2680843C (en) * 2007-01-29 2016-05-31 Vlife Sciences Technologies Pvt. Ltd. Pharmaceutical composition for treatment of diabetic complications
ES2841379T3 (es) 2007-03-13 2021-07-08 Jds Therapeutics Llc Procedimientos y composiciones para la liberación sostenida de cromo
WO2010017120A1 (en) 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
WO2010042475A1 (en) 2008-10-07 2010-04-15 Schering Corporation Spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
TW201024282A (en) 2008-11-20 2010-07-01 Orion Corp New pharmaceutical compounds
EA020548B1 (ru) * 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
ES2756499T3 (es) * 2009-10-06 2020-04-27 Allergan Inc Derivados de 2H-pirrol-5-amina como moduladores de receptor alfa adrenérgico
US20130210840A1 (en) * 2010-06-11 2013-08-15 Imprimis Pharmaceuticals, Inc. Anti-Cellulite Composition and Method of Treating Cellulite
WO2012127506A1 (en) 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
EP3083610A1 (de) * 2013-12-19 2016-10-26 Bayer Pharma Aktiengesellschaft Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
AU2014364735A1 (en) * 2013-12-19 2016-07-07 Bayer Pharma Aktiengesellschaft Substituted piperidinyl-tetrahydroquinolines

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