SI3083592T1 - Substituirani piperidinil-tetrahidrokinolini in njihova uporaba kot antagonisti adrenoreceptorja alfa-2c - Google Patents

Substituirani piperidinil-tetrahidrokinolini in njihova uporaba kot antagonisti adrenoreceptorja alfa-2c

Info

Publication number
SI3083592T1
SI3083592T1 SI201430831T SI201430831T SI3083592T1 SI 3083592 T1 SI3083592 T1 SI 3083592T1 SI 201430831 T SI201430831 T SI 201430831T SI 201430831 T SI201430831 T SI 201430831T SI 3083592 T1 SI3083592 T1 SI 3083592T1
Authority
SI
Slovenia
Prior art keywords
tetrahydroquinolines
alpha
substituted piperidinyl
adrenoreceptor antagonists
adrenoreceptor
Prior art date
Application number
SI201430831T
Other languages
English (en)
Inventor
Eva Maria Becker-Pelster
Philipp Buchgraber
Anja Buchmuller
Karen Engel
Volker Geiss
Andreas Goller
Herbert Himmel
Raimund Kast
Andreas Knorr
Dieter Lang
Gorden Redlich
Carsten Schmeck
Hanna Tinel
Frank Wunder
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of SI3083592T1 publication Critical patent/SI3083592T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201430831T 2013-12-19 2014-12-16 Substituirani piperidinil-tetrahidrokinolini in njihova uporaba kot antagonisti adrenoreceptorja alfa-2c SI3083592T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13198385 2013-12-19
EP14192877 2014-11-12
EP14812245.0A EP3083592B1 (de) 2013-12-19 2014-12-16 Substituierte piperidinyl-tetrahydrochinoline und ihre verwendung als alpha-2c adrenorezeptor antagonisten
PCT/EP2014/077862 WO2015091414A2 (de) 2013-12-19 2014-12-16 Substituierte piperidinyl-tetrahydrochinoline

Publications (1)

Publication Number Publication Date
SI3083592T1 true SI3083592T1 (sl) 2018-09-28

Family

ID=52101341

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201430831T SI3083592T1 (sl) 2013-12-19 2014-12-16 Substituirani piperidinil-tetrahidrokinolini in njihova uporaba kot antagonisti adrenoreceptorja alfa-2c

Country Status (38)

Country Link
US (3) US9944621B2 (sl)
EP (2) EP3329920A3 (sl)
JP (2) JP6487922B2 (sl)
KR (1) KR20160098425A (sl)
CN (1) CN106458978B (sl)
AP (1) AP2016009276A0 (sl)
AU (2) AU2014364732B2 (sl)
BR (1) BR112016014008A2 (sl)
CA (1) CA2934108C (sl)
CL (1) CL2016001578A1 (sl)
CR (1) CR20160276A (sl)
CU (1) CU24390B1 (sl)
CY (1) CY1120701T1 (sl)
DK (1) DK3083592T3 (sl)
DO (1) DOP2016000149A (sl)
EA (1) EA032250B1 (sl)
ES (1) ES2689023T3 (sl)
HR (1) HRP20181536T1 (sl)
HU (1) HUE039942T2 (sl)
IL (1) IL246246B (sl)
JO (2) JOP20200052A1 (sl)
LT (1) LT3083592T (sl)
MX (1) MX365289B (sl)
MY (1) MY177393A (sl)
NI (1) NI201600084A (sl)
NZ (2) NZ758272A (sl)
PE (1) PE20160846A1 (sl)
PH (1) PH12016501190A1 (sl)
PL (1) PL3083592T3 (sl)
PT (1) PT3083592T (sl)
RS (1) RS57835B1 (sl)
SG (1) SG11201604978QA (sl)
SI (1) SI3083592T1 (sl)
TN (1) TN2016000250A1 (sl)
TW (1) TWI667234B (sl)
UA (1) UA120702C2 (sl)
UY (1) UY35887A (sl)
WO (1) WO2015091414A2 (sl)

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JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
EP3373936A1 (en) 2015-11-13 2018-09-19 Bayer Pharma Aktiengesellschaft 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
WO2018197333A1 (en) 2017-04-27 2018-11-01 Bayer Aktiengesellschaft Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
CN110917195A (zh) * 2018-08-20 2020-03-27 山西惠尔健生物科技有限公司 肌松剂阿库氯铵（Alcuronium chloride）可作为抗心律失常药物
CA3120152A1 (en) * 2018-11-20 2020-05-28 Bayer Aktiengesellschaft A2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea
WO2020165031A1 (de) 2019-02-15 2020-08-20 Bayer Aktiengesellschaft Substituierte isochinolin-piperidinylmethanon-derivate
WO2020182018A1 (zh) * 2019-03-12 2020-09-17 四川科伦博泰生物医药股份有限公司 氮杂环化合物、其制备方法及用途
TWI804119B (zh) * 2020-12-21 2023-06-01 大陸商上海濟煜醫藥科技有限公司 三氮唑類三并環衍生物及其製備方法和應用

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