CL2015001537A1 - Compuestos derivados de piridin-2-amidas agonistas cb2; proceso de sintesis; composicion farmaceutica; uso en el tratamiento o profilaxis del dolor, aterosclerosis, retinopatia diabetica, glaucoma, diabetes mellitus, entre otras. - Google Patents

Compuestos derivados de piridin-2-amidas agonistas cb2; proceso de sintesis; composicion farmaceutica; uso en el tratamiento o profilaxis del dolor, aterosclerosis, retinopatia diabetica, glaucoma, diabetes mellitus, entre otras.

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Publication number
CL2015001537A1
CL2015001537A1 CL2015001537A CL2015001537A CL2015001537A1 CL 2015001537 A1 CL2015001537 A1 CL 2015001537A1 CL 2015001537 A CL2015001537 A CL 2015001537A CL 2015001537 A CL2015001537 A CL 2015001537A CL 2015001537 A1 CL2015001537 A1 CL 2015001537A1
Authority
CL
Chile
Prior art keywords
pbidin
glaucoma
prophylaxis
atherosclerosis
agonist
Prior art date
Application number
CL2015001537A
Other languages
English (en)
Inventor
Uwe Grether
Atsushi Kimbara
Matthias Nettekoven
Stephan Roever
Mark Rogers-Evans
Tanja Schulz-Gasch
Fabienne Ricklin
Matthias Westphal
Didier Rombach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2015001537A1 publication Critical patent/CL2015001537A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/10—Spiro-condensed systems
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CL2015001537A 2012-12-07 2015-06-05 Compuestos derivados de piridin-2-amidas agonistas cb2; proceso de sintesis; composicion farmaceutica; uso en el tratamiento o profilaxis del dolor, aterosclerosis, retinopatia diabetica, glaucoma, diabetes mellitus, entre otras. CL2015001537A1 (es)

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EP12196029 2012-12-07

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CL2015001537A1 true CL2015001537A1 (es) 2015-10-23

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CL2015001537A CL2015001537A1 (es) 2012-12-07 2015-06-05 Compuestos derivados de piridin-2-amidas agonistas cb2; proceso de sintesis; composicion farmaceutica; uso en el tratamiento o profilaxis del dolor, aterosclerosis, retinopatia diabetica, glaucoma, diabetes mellitus, entre otras.

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US (1) US9409866B2 (es)
EP (1) EP2928867B1 (es)
JP (1) JP6280132B2 (es)
KR (1) KR20150092232A (es)
CN (1) CN104837818B (es)
AR (1) AR093805A1 (es)
AU (1) AU2013354113B2 (es)
BR (1) BR112015013124A2 (es)
CA (1) CA2890353A1 (es)
CL (1) CL2015001537A1 (es)
CO (1) CO7350652A2 (es)
CR (1) CR20150277A (es)
DK (1) DK2928867T3 (es)
EA (1) EA027780B1 (es)
ES (1) ES2643056T3 (es)
HK (1) HK1210147A1 (es)
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MA (1) MA38238B1 (es)
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SG (1) SG11201504475QA (es)
SI (1) SI2928867T1 (es)
TW (1) TWI629263B (es)
UA (1) UA114657C2 (es)
WO (1) WO2014086805A1 (es)
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SI2964646T1 (sl) 2013-03-07 2017-08-31 F. Hoffmann-La Roche Ag Novi derivati pirazola
PL2978755T3 (pl) 2013-03-26 2018-05-30 Hoffmann La Roche Nowe pochodne pirydyny
EP2991987B1 (en) 2013-05-02 2018-05-23 F.Hoffmann-La Roche Ag Purine derivatives as cb2 receptor agonists
CN105164133B (zh) 2013-05-02 2018-02-13 豪夫迈·罗氏有限公司 作为CB2受体激动剂的吡咯并[2，3‑d]嘧啶衍生物
UA116395C2 (uk) 2013-09-06 2018-03-12 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ ТРИАЗОЛ[4,5-b]ПІРИМІДИНУ
KR20160106627A (ko) * 2013-12-30 2016-09-12 라이프에스씨아이 파마슈티컬스, 인크. 치료적 억제 화합물
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