CL2016001918A1 - Heteroaril amidas como inhibidores de agregación de proteína - Google Patents

Heteroaril amidas como inhibidores de agregación de proteína

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Publication number
CL2016001918A1
CL2016001918A1 CL2016001918A CL2016001918A CL2016001918A1 CL 2016001918 A1 CL2016001918 A1 CL 2016001918A1 CL 2016001918 A CL2016001918 A CL 2016001918A CL 2016001918 A CL2016001918 A CL 2016001918A CL 2016001918 A1 CL2016001918 A1 CL 2016001918A1
Authority
CL
Chile
Prior art keywords
protein aggregation
aggregation inhibitors
disease
heteroaryl amides
protein
Prior art date
Application number
CL2016001918A
Other languages
English (en)
Inventor
Emily M Stocking
Wolfgang Wrasidlo
Original Assignee
Neuropore Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016001918(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuropore Therapies Inc filed Critical Neuropore Therapies Inc
Publication of CL2016001918A1 publication Critical patent/CL2016001918A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE INDOL-ETIL-HETEROARIL-AMIDAS,INHIBIDORES DE AGRAGACIÓN DE PROTEÍNA; COMPOSICION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD O CON DICION MEDICA ASOCIADA CON LA AGREGACION PROTEICA, TAL COMO ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PAKINSON, ENTRE OTRAS.</p>
CL2016001918A 2014-01-29 2016-07-28 Heteroaril amidas como inhibidores de agregación de proteína CL2016001918A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12

Publications (1)

Publication Number Publication Date
CL2016001918A1 true CL2016001918A1 (es) 2017-01-13

Family

ID=52484559

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001918A CL2016001918A1 (es) 2014-01-29 2016-07-28 Heteroaril amidas como inhibidores de agregación de proteína

Country Status (38)

Country Link
US (3) US9738635B2 (es)
EP (2) EP3099684B8 (es)
JP (2) JP6619741B2 (es)
KR (1) KR102383038B1 (es)
CN (2) CN111039939B (es)
AP (1) AP2016009347A0 (es)
AU (1) AU2015211119B2 (es)
BR (2) BR122018001892B1 (es)
CA (1) CA2937967C (es)
CL (1) CL2016001918A1 (es)
CR (1) CR20160394A (es)
CY (2) CY1120348T1 (es)
DK (2) DK3348556T3 (es)
EA (1) EA032374B1 (es)
EC (1) ECSP16070327A (es)
ES (2) ES2808978T3 (es)
HK (1) HK1231470A1 (es)
HR (2) HRP20180813T1 (es)
HU (2) HUE050964T2 (es)
IL (1) IL246987B (es)
LT (2) LT3099684T (es)
ME (1) ME03800B (es)
MX (1) MX2016009896A (es)
MY (1) MY187450A (es)
NZ (1) NZ722487A (es)
PE (1) PE20161393A1 (es)
PH (1) PH12016501493B1 (es)
PL (2) PL3099684T3 (es)
PT (2) PT3099684T (es)
RS (2) RS60547B1 (es)
SA (1) SA516371579B1 (es)
SG (1) SG11201606108RA (es)
SI (2) SI3099684T1 (es)
SM (2) SMT201800318T1 (es)
TR (1) TR201809440T4 (es)
UA (1) UA118209C2 (es)
WO (1) WO2015116663A1 (es)
ZA (1) ZA201605246B (es)

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WO2017020010A1 (en) 2015-07-29 2017-02-02 Neuropore Therapies, Inc. Bis-heteroaryl derivatives as modulators of protein aggregation
ES2884145T3 (es) 2017-01-26 2021-12-10 UCB Biopharma SRL Derivados bicíclicos de bis-heteroarilo como moduladores de la agregación de proteínas
ES2882285T3 (es) 2017-01-26 2021-12-01 Ucb Biopharma Sprl Derivados de bis-heteroarilo como moduladores de la agregación de proteínas

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US10358443B2 (en) 2019-07-23
UA118209C2 (uk) 2018-12-10
WO2015116663A1 (en) 2015-08-06
HRP20180813T1 (hr) 2018-07-27
SG11201606108RA (en) 2016-08-30
BR112016017344B1 (pt) 2023-05-16
CY1123374T1 (el) 2021-12-31
BR112016017344A2 (pt) 2017-10-03
LT3099684T (lt) 2018-06-25
ES2808978T3 (es) 2021-03-02
CN106132960A (zh) 2016-11-16
AP2016009347A0 (en) 2016-07-31
CN106132960B (zh) 2019-12-17
MY187450A (en) 2021-09-22
JP6619741B2 (ja) 2019-12-11
US9738635B2 (en) 2017-08-22
CN111039939B (zh) 2023-09-19
EP3099684B1 (en) 2018-04-04
EP3348556B1 (en) 2020-04-29
SA516371579B1 (ar) 2019-07-16
PL3099684T3 (pl) 2018-09-28
EP3099684B8 (en) 2018-07-04
HRP20201107T8 (hr) 2020-12-11
JP2017505779A (ja) 2017-02-23
IL246987A0 (en) 2016-09-29
CN111039939A (zh) 2020-04-21
ECSP16070327A (es) 2018-05-31
HRP20201107T1 (hr) 2020-10-30
AU2015211119B2 (en) 2019-05-30
PH12016501493A1 (en) 2017-02-06
PL3348556T3 (pl) 2020-11-02
CY1120348T1 (el) 2019-07-10
KR20160113287A (ko) 2016-09-28
EP3348556A1 (en) 2018-07-18
HK1231470A1 (zh) 2017-12-22
HUE040274T2 (hu) 2019-03-28
ES2808978T8 (es) 2021-03-22
RS57533B1 (sr) 2018-10-31
ME03800B (me) 2021-04-20
PT3348556T (pt) 2020-07-27
US11078196B2 (en) 2021-08-03
DK3348556T3 (da) 2020-08-03
BR122018001892B1 (pt) 2023-05-02
PT3099684T (pt) 2018-10-22
NZ722487A (en) 2022-04-29
DK3099684T3 (en) 2018-07-16
TR201809440T4 (tr) 2018-07-23
CA2937967A1 (en) 2015-08-06
CA2937967C (en) 2022-07-26
AU2015211119A1 (en) 2016-08-11
PH12016501493B1 (en) 2017-02-06
CR20160394A (es) 2016-11-01
ZA201605246B (en) 2022-05-25
SMT202000376T1 (it) 2020-09-10
US20190308965A1 (en) 2019-10-10
KR102383038B1 (ko) 2022-04-05
LT3348556T (lt) 2020-08-10
HUE050964T2 (hu) 2021-01-28
EA032374B1 (ru) 2019-05-31
PE20161393A1 (es) 2017-01-08
US20160207912A1 (en) 2016-07-21
AU2015211119A8 (en) 2016-12-15
IL246987B (en) 2021-12-01
RS60547B1 (sr) 2020-08-31
US20180093979A1 (en) 2018-04-05
SI3099684T1 (en) 2018-08-31
JP2019163321A (ja) 2019-09-26
JP6783900B2 (ja) 2020-11-11
SI3348556T1 (sl) 2020-10-30
ES2675301T3 (es) 2018-07-10
EA201691529A1 (ru) 2017-01-30
SMT201800318T1 (it) 2018-07-17
MX2016009896A (es) 2017-01-11
EP3099684A1 (en) 2016-12-07
WO2015116663A8 (en) 2016-09-15

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