PL3099684T3 - Heteroaryloamidy jako inhibitory agregacji białka - Google Patents

Heteroaryloamidy jako inhibitory agregacji białka

Info

Publication number
PL3099684T3
PL3099684T3 PL15705417T PL15705417T PL3099684T3 PL 3099684 T3 PL3099684 T3 PL 3099684T3 PL 15705417 T PL15705417 T PL 15705417T PL 15705417 T PL15705417 T PL 15705417T PL 3099684 T3 PL3099684 T3 PL 3099684T3
Authority
PL
Poland
Prior art keywords
inhibitors
protein aggregation
heteroaryl amides
heteroaryl
amides
Prior art date
Application number
PL15705417T
Other languages
English (en)
Inventor
Emily M. Stocking
Wolfgang Wrasidlo
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3099684(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of PL3099684T3 publication Critical patent/PL3099684T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL15705417T 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka PL3099684T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12
PCT/US2015/013263 WO2015116663A1 (en) 2014-01-29 2015-01-28 Heteroarly amides as inhibitors of protein aggregation
EP15705417.2A EP3099684B8 (en) 2014-01-29 2015-01-28 Heteroaryl amides as inhibitors of protein aggregation

Publications (1)

Publication Number Publication Date
PL3099684T3 true PL3099684T3 (pl) 2018-09-28

Family

ID=52484559

Family Applications (2)

Application Number Title Priority Date Filing Date
PL18156929T PL3348556T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka
PL15705417T PL3099684T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL18156929T PL3348556T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka

Country Status (38)

Country Link
US (3) US9738635B2 (pl)
EP (2) EP3099684B8 (pl)
JP (2) JP6619741B2 (pl)
KR (1) KR102383038B1 (pl)
CN (2) CN111039939B (pl)
AP (1) AP2016009347A0 (pl)
AU (1) AU2015211119B2 (pl)
BR (2) BR112016017344B1 (pl)
CA (1) CA2937967C (pl)
CL (1) CL2016001918A1 (pl)
CR (1) CR20160394A (pl)
CY (2) CY1120348T1 (pl)
DK (2) DK3348556T3 (pl)
EA (1) EA032374B1 (pl)
EC (1) ECSP16070327A (pl)
ES (2) ES2675301T3 (pl)
HK (1) HK1231470A1 (pl)
HR (2) HRP20180813T1 (pl)
HU (2) HUE050964T2 (pl)
IL (1) IL246987B (pl)
LT (2) LT3099684T (pl)
ME (1) ME03800B (pl)
MX (1) MX2016009896A (pl)
MY (1) MY187450A (pl)
NZ (1) NZ722487A (pl)
PE (1) PE20161393A1 (pl)
PH (1) PH12016501493A1 (pl)
PL (2) PL3348556T3 (pl)
PT (2) PT3348556T (pl)
RS (2) RS57533B1 (pl)
SA (1) SA516371579B1 (pl)
SG (1) SG11201606108RA (pl)
SI (2) SI3348556T1 (pl)
SM (2) SMT201800318T1 (pl)
TR (1) TR201809440T4 (pl)
UA (1) UA118209C2 (pl)
WO (1) WO2015116663A1 (pl)
ZA (1) ZA201605246B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3348556T3 (pl) 2014-01-29 2020-11-02 UCB Biopharma SRL Heteroaryloamidy jako inhibitory agregacji białka
EP3328379B1 (en) * 2015-07-29 2021-07-28 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
CN106474121B (zh) * 2016-11-25 2017-10-10 刘淑兰 一种治疗慢性盆腔炎的药物
US20200087390A1 (en) 2016-12-21 2020-03-19 Amgen Inc. Anti-tnf alpha antibody formulations
US10889584B2 (en) * 2017-01-26 2021-01-12 UCB Biopharma SRL Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
MX2019007053A (es) * 2017-01-26 2019-08-29 Ucb Biopharma Sprl Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas.
EA201991753A1 (ru) * 2017-01-26 2020-01-14 Юсб Байофарма Спрл Алкоксибисгетероарильные производные в качестве модуляторов агрегации белков
JP7283699B2 (ja) * 2017-05-12 2023-05-30 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 黒色腫の治療または予防において使用するためのフェニル－ヘテロ環－フェニル誘導体
EP3664822A4 (en) * 2017-08-04 2021-07-07 Axial Therapeutics, Inc. MICROBIAL INDUCED AMYLOID FORMATION INHIBITORS
EP3703730A4 (en) * 2017-10-31 2022-01-12 Loma Linda University METHODS OF TREATMENT OF TRAUMATIC BRAIN LESIONS
US11707452B2 (en) 2018-08-20 2023-07-25 Arvinas Operations, Inc. Modulators of alpha-synuclein proteolysis and associated methods of use
EP4458824A4 (en) 2021-12-27 2025-12-24 Shanghai Jingxin Biomedical Co Ltd Fused bicyclic heteroarylamide compound useful as a protein aggregation inhibitor
GB202213796D0 (en) * 2022-09-21 2022-11-02 Wista Lab Ltd Tau aggregation inhibitors
JP2025541967A (ja) * 2022-11-02 2025-12-24 エーシー・イミューン・エス・アー Ｔｄｐ－４３タンパク質症の診断のための新規化合物
WO2024184180A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
WO2024184179A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
CN121487929A (zh) * 2023-06-25 2026-02-06 上海京新生物医药有限公司 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1463997A (en) * 1995-12-22 1997-07-17 Acea Pharmaceuticals, Inc. Subtype-selective nmda receptor ligands and the use thereof
KR20050084027A (ko) * 2002-11-28 2005-08-26 쉐링 악티엔게젤샤프트 Ｃｈｋ-, ｐｄｋ- 및 ａｋｔ-억제성 피리미딘, 그의제조방법 및 약제로서의 그의 용도
CN100536837C (zh) * 2003-02-27 2009-09-09 乔安妮·麦克劳林 鲨肌醇在制备诊断试剂中的用途
KR20070018824A (ko) * 2003-12-19 2007-02-14 브리스톨-마이어스 스큅 컴퍼니 카나비노이드 수용체 조절제인 아자비사이클릭헤테로사이클
ES2284081T3 (es) * 2003-12-19 2007-11-01 Bristol-Myers Squibb Company Heterociclos azabiciclicos como modulares de receptores canabinoides.
TW200530246A (en) * 2003-12-19 2005-09-16 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators
GEP20104906B (en) * 2004-08-26 2010-02-25 Pfizer Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
BRPI0516958A (pt) * 2004-09-20 2008-03-25 4Sc Ag inibidores da nf-capab heterocìclicos
SE0403119D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab Therapeutic agents
BRPI0615524A2 (pt) * 2005-07-11 2010-04-06 Devgen Nv derivados da amida como inibidores da quinase
WO2007016979A2 (en) * 2005-07-29 2007-02-15 4Sc Ag NOVEL HETEROCYCLIC NF-κB INHIBITORS
EA200801838A1 (ru) * 2006-03-15 2009-02-27 4ЭсЦэ АГ НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-kB
EP2081892A4 (en) * 2006-11-17 2014-03-05 Donald F Weaver COMPOUNDS AND METHOD FOR THE TREATMENT OF PROTEIN DISAPPEARANCE
WO2008157425A2 (en) * 2007-06-14 2008-12-24 The Regents Of The University Of California Compounds for inhibiting protein aggregation, and methods for making and using them
US8598356B2 (en) * 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
GB0910003D0 (en) * 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
JP2013508350A (ja) * 2009-10-20 2013-03-07 ファイザー・インク ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール
WO2011084642A1 (en) 2009-12-16 2011-07-14 Neuropore Therapies, Inc. Compound suitable for the treatment of synucleopathies
GB201021103D0 (en) * 2010-12-13 2011-01-26 Univ Leuven Kath New compounds for the treatment of neurodegenerative diseases
WO2013134371A1 (en) 2012-03-06 2013-09-12 Neuropore Therapies, Inc. Methods and compounds to be used in the treatment of neurodegenerative diseases
JP6159388B2 (ja) 2012-03-28 2017-07-05 ニューロポア セラピーズ，インコーポレイティド タンパク質凝集の阻害剤としてのフェニル−尿素及びフェニル−カルバメート誘導体
ES2661394T3 (es) 2012-07-16 2018-03-28 Neuropore Therapies, Inc. Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas
PL3348556T3 (pl) 2014-01-29 2020-11-02 UCB Biopharma SRL Heteroaryloamidy jako inhibitory agregacji białka
EP3328379B1 (en) 2015-07-29 2021-07-28 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
US10889584B2 (en) 2017-01-26 2021-01-12 UCB Biopharma SRL Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
MX2019007053A (es) 2017-01-26 2019-08-29 Ucb Biopharma Sprl Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas.

Also Published As

Publication number Publication date
HRP20201107T8 (hr) 2020-12-11
JP2017505779A (ja) 2017-02-23
US20180093979A1 (en) 2018-04-05
EP3099684B1 (en) 2018-04-04
CN111039939B (zh) 2023-09-19
CY1123374T1 (el) 2021-12-31
RS60547B1 (sr) 2020-08-31
HUE050964T2 (hu) 2021-01-28
EA032374B1 (ru) 2019-05-31
UA118209C2 (uk) 2018-12-10
WO2015116663A1 (en) 2015-08-06
HRP20180813T1 (hr) 2018-07-27
PH12016501493B1 (en) 2017-02-06
CN111039939A (zh) 2020-04-21
LT3348556T (lt) 2020-08-10
CN106132960A (zh) 2016-11-16
KR102383038B1 (ko) 2022-04-05
US10358443B2 (en) 2019-07-23
EP3099684B8 (en) 2018-07-04
SMT201800318T1 (it) 2018-07-17
HUE040274T2 (hu) 2019-03-28
SG11201606108RA (en) 2016-08-30
EP3348556A1 (en) 2018-07-18
ES2675301T3 (es) 2018-07-10
RS57533B1 (sr) 2018-10-31
CL2016001918A1 (es) 2017-01-13
PT3099684T (pt) 2018-10-22
EP3348556B1 (en) 2020-04-29
US11078196B2 (en) 2021-08-03
KR20160113287A (ko) 2016-09-28
ECSP16070327A (es) 2018-05-31
CA2937967C (en) 2022-07-26
IL246987B (en) 2021-12-01
PL3348556T3 (pl) 2020-11-02
LT3099684T (lt) 2018-06-25
AU2015211119B2 (en) 2019-05-30
ES2808978T8 (es) 2021-03-22
SA516371579B1 (ar) 2019-07-16
DK3099684T3 (en) 2018-07-16
AP2016009347A0 (en) 2016-07-31
CR20160394A (es) 2016-11-01
MY187450A (en) 2021-09-22
BR112016017344B1 (pt) 2023-05-16
CN106132960B (zh) 2019-12-17
BR122018001892B1 (pt) 2023-05-02
MX2016009896A (es) 2017-01-11
US20190308965A1 (en) 2019-10-10
US9738635B2 (en) 2017-08-22
SI3348556T1 (sl) 2020-10-30
SMT202000376T1 (it) 2020-09-10
JP2019163321A (ja) 2019-09-26
AU2015211119A1 (en) 2016-08-11
CA2937967A1 (en) 2015-08-06
US20160207912A1 (en) 2016-07-21
PT3348556T (pt) 2020-07-27
AU2015211119A8 (en) 2016-12-15
PE20161393A1 (es) 2017-01-08
EP3099684A1 (en) 2016-12-07
ZA201605246B (en) 2022-05-25
IL246987A0 (en) 2016-09-29
HRP20201107T1 (hr) 2020-10-30
DK3348556T3 (da) 2020-08-03
JP6783900B2 (ja) 2020-11-11
NZ722487A (en) 2022-04-29
WO2015116663A8 (en) 2016-09-15
EA201691529A1 (ru) 2017-01-30
ME03800B (me) 2021-04-20
PH12016501493A1 (en) 2017-02-06
HK1231470A1 (zh) 2017-12-22
JP6619741B2 (ja) 2019-12-11
TR201809440T4 (tr) 2018-07-23
ES2808978T3 (es) 2021-03-02
CY1120348T1 (el) 2019-07-10
BR112016017344A2 (pt) 2017-10-03
SI3099684T1 (en) 2018-08-31

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