PL3099684T3 - Heteroaryloamidy jako inhibitory agregacji białka - Google Patents

Heteroaryloamidy jako inhibitory agregacji białka

Info

Publication number
PL3099684T3
PL3099684T3 PL15705417T PL15705417T PL3099684T3 PL 3099684 T3 PL3099684 T3 PL 3099684T3 PL 15705417 T PL15705417 T PL 15705417T PL 15705417 T PL15705417 T PL 15705417T PL 3099684 T3 PL3099684 T3 PL 3099684T3
Authority
PL
Poland
Prior art keywords
inhibitors
protein aggregation
heteroaryl amides
heteroaryl
amides
Prior art date
Application number
PL15705417T
Other languages
English (en)
Inventor
Emily M. Stocking
Wolfgang Wrasidlo
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3099684(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of PL3099684T3 publication Critical patent/PL3099684T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL15705417T 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka PL3099684T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12
EP15705417.2A EP3099684B8 (en) 2014-01-29 2015-01-28 Heteroaryl amides as inhibitors of protein aggregation
PCT/US2015/013263 WO2015116663A1 (en) 2014-01-29 2015-01-28 Heteroarly amides as inhibitors of protein aggregation

Publications (1)

Publication Number Publication Date
PL3099684T3 true PL3099684T3 (pl) 2018-09-28

Family

ID=52484559

Family Applications (2)

Application Number Title Priority Date Filing Date
PL18156929T PL3348556T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka
PL15705417T PL3099684T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL18156929T PL3348556T3 (pl) 2014-01-29 2015-01-28 Heteroaryloamidy jako inhibitory agregacji białka

Country Status (38)

Country Link
US (3) US9738635B2 (pl)
EP (2) EP3348556B1 (pl)
JP (2) JP6619741B2 (pl)
KR (1) KR102383038B1 (pl)
CN (2) CN106132960B (pl)
AP (1) AP2016009347A0 (pl)
AU (1) AU2015211119B2 (pl)
BR (2) BR112016017344B1 (pl)
CA (1) CA2937967C (pl)
CL (1) CL2016001918A1 (pl)
CR (1) CR20160394A (pl)
CY (2) CY1120348T1 (pl)
DK (2) DK3348556T3 (pl)
EA (1) EA032374B1 (pl)
EC (1) ECSP16070327A (pl)
ES (2) ES2675301T3 (pl)
HK (1) HK1231470A1 (pl)
HR (2) HRP20180813T1 (pl)
HU (2) HUE040274T2 (pl)
IL (1) IL246987B (pl)
LT (2) LT3099684T (pl)
ME (1) ME03800B (pl)
MX (1) MX2016009896A (pl)
MY (1) MY187450A (pl)
NZ (1) NZ722487A (pl)
PE (1) PE20161393A1 (pl)
PH (1) PH12016501493A1 (pl)
PL (2) PL3348556T3 (pl)
PT (2) PT3099684T (pl)
RS (2) RS57533B1 (pl)
SA (1) SA516371579B1 (pl)
SG (1) SG11201606108RA (pl)
SI (2) SI3348556T1 (pl)
SM (2) SMT201800318T1 (pl)
TR (1) TR201809440T4 (pl)
UA (1) UA118209C2 (pl)
WO (1) WO2015116663A1 (pl)
ZA (1) ZA201605246B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032374B1 (ru) 2014-01-29 2019-05-31 ЮСиБи БАЙОФАРМА СПРЛ Гетероарильные амиды в качестве ингибиторов агрегации белков
EP3328379B1 (en) * 2015-07-29 2021-07-28 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
CN106474121B (zh) * 2016-11-25 2017-10-10 刘淑兰 一种治疗慢性盆腔炎的药物
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations
RU2019126170A (ru) * 2017-01-26 2021-02-26 Юсб Байофарма Спрл Бисгетероарильные производные в качестве модуляторов агрегации белков
EA201991755A1 (ru) 2017-01-26 2020-01-22 Юсб Байофарма Спрл Бициклические бисгетероарильные производные в качестве модуляторов агрегации белков
RU2019126164A (ru) * 2017-01-26 2021-02-26 Юсб Байофмарма Спрл Алкоксибисгетероарильные производные в качестве модуляторов агрегации белков
EP3634403B1 (en) * 2017-05-12 2025-06-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
US11505528B2 (en) 2017-08-04 2022-11-22 Axial Therapeutics, Inc. Inhibitors of microbially induced amyloid
EP3703730A4 (en) * 2017-10-31 2022-01-12 Loma Linda University METHODS OF TREATMENT OF TRAUMATIC BRAIN LESIONS
CN112912376A (zh) 2018-08-20 2021-06-04 阿尔维纳斯运营股份有限公司 用于治疗神经变性疾病的具有E3泛素连接酶结合活性并靶向α-突触核蛋白的蛋白水解靶向嵌合(PROTAC)化合物
US20250074902A1 (en) 2021-12-27 2025-03-06 Shanghai Jingxin Biomedical Co., Ltd. Fused bicyclic heteroaryl amide compound as protein aggregation inhibitor
GB202213796D0 (en) * 2022-09-21 2022-11-02 Wista Lab Ltd Tau aggregation inhibitors
CN120265630A (zh) * 2022-11-02 2025-07-04 Ac免疫有限公司 用于诊断tdp-43蛋白质病的新化合物
WO2024184180A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
WO2024184179A1 (en) 2023-03-06 2024-09-12 UCB Biopharma SRL Minzasolmin for use in the treatment of parkinson's disease
CN121487929A (zh) * 2023-06-25 2026-02-06 上海京新生物医药有限公司 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1463997A (en) * 1995-12-22 1997-07-17 Acea Pharmaceuticals, Inc. Subtype-selective nmda receptor ligands and the use thereof
BR0316680A (pt) * 2002-11-28 2005-10-18 Schering Ag Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos
CN101385722A (zh) * 2003-02-27 2009-03-18 乔安妮·麦克劳林 预防、治疗和诊断蛋白聚集疾病的方法
WO2005063762A1 (en) * 2003-12-19 2005-07-14 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
TW200528455A (en) * 2003-12-19 2005-09-01 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators
KR20070018824A (ko) * 2003-12-19 2007-02-14 브리스톨-마이어스 스큅 컴퍼니 카나비노이드 수용체 조절제인 아자비사이클릭헤테로사이클
GEP20104906B (en) * 2004-08-26 2010-02-25 Pfizer Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
BRPI0516958A (pt) * 2004-09-20 2008-03-25 4Sc Ag inibidores da nf-capab heterocìclicos
SE0403119D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab Therapeutic agents
WO2007006546A1 (en) 2005-07-11 2007-01-18 Devgen N.V. Amide derivatives as kinase inhibitors
UA97348C2 (en) * 2005-07-29 2012-02-10 4Сц Аг HETEROCYCLIC NF-kB INHIBITORS
BRPI0709595A2 (pt) * 2006-03-15 2011-07-19 4Sc Ag inibidores de nf-kapab heterocìclicos
CA2668744C (en) * 2006-11-17 2015-09-15 Queen's University At Kingston Compounds and methods for treating protein folding disorders
EP2155226A4 (en) * 2007-06-14 2010-07-28 Univ California COMPOUNDS FOR INHIBITING THE PROTEIN AGGREGATION AND METHOD FOR THE PRODUCTION AND USE THEREOF
US8598356B2 (en) * 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
GB0910003D0 (en) * 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US20120202787A1 (en) 2009-10-20 2012-08-09 Pfizer Inc. Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
MX335989B (es) * 2009-12-16 2016-01-07 Neuropore Therapies Inc Compuesto adecuado para el tratamiento de sinucleopatias.
GB201021103D0 (en) 2010-12-13 2011-01-26 Univ Leuven Kath New compounds for the treatment of neurodegenerative diseases
WO2013134371A1 (en) 2012-03-06 2013-09-12 Neuropore Therapies, Inc. Methods and compounds to be used in the treatment of neurodegenerative diseases
ES2768602T3 (es) 2012-03-28 2020-06-23 UCB Biopharma SRL Derivados de fenil-urea y de fenil-carbamato como inhibidores de la agregación de proteínas
RU2015104962A (ru) * 2012-07-16 2016-09-10 Ньюропор Терапис, Инк. Ди- и тригетероарильные производные в качестве ингибиторов агрегации белков
EA032374B1 (ru) 2014-01-29 2019-05-31 ЮСиБи БАЙОФАРМА СПРЛ Гетероарильные амиды в качестве ингибиторов агрегации белков
EP3328379B1 (en) 2015-07-29 2021-07-28 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
RU2019126170A (ru) 2017-01-26 2021-02-26 Юсб Байофарма Спрл Бисгетероарильные производные в качестве модуляторов агрегации белков
EA201991755A1 (ru) 2017-01-26 2020-01-22 Юсб Байофарма Спрл Бициклические бисгетероарильные производные в качестве модуляторов агрегации белков

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RS57533B1 (sr) 2018-10-31
BR112016017344A2 (pt) 2017-10-03
UA118209C2 (uk) 2018-12-10
PH12016501493B1 (en) 2017-02-06
SMT202000376T1 (it) 2020-09-10
SA516371579B1 (ar) 2019-07-16
US20180093979A1 (en) 2018-04-05
CL2016001918A1 (es) 2017-01-13
PT3348556T (pt) 2020-07-27
US11078196B2 (en) 2021-08-03
MX2016009896A (es) 2017-01-11
ES2675301T3 (es) 2018-07-10
TR201809440T4 (tr) 2018-07-23
SI3348556T1 (sl) 2020-10-30
LT3099684T (lt) 2018-06-25
IL246987A0 (en) 2016-09-29
SMT201800318T1 (it) 2018-07-17
NZ722487A (en) 2022-04-29
HRP20201107T8 (hr) 2020-12-11
JP2017505779A (ja) 2017-02-23
JP6783900B2 (ja) 2020-11-11
ECSP16070327A (es) 2018-05-31
PL3348556T3 (pl) 2020-11-02
IL246987B (en) 2021-12-01
CN106132960A (zh) 2016-11-16
CN106132960B (zh) 2019-12-17
ES2808978T3 (es) 2021-03-02
EP3099684A1 (en) 2016-12-07
ES2808978T8 (es) 2021-03-22
CY1120348T1 (el) 2019-07-10
US20190308965A1 (en) 2019-10-10
BR112016017344B1 (pt) 2023-05-16
HK1231470A1 (zh) 2017-12-22
HRP20180813T1 (hr) 2018-07-27
CY1123374T1 (el) 2021-12-31
HUE040274T2 (hu) 2019-03-28
ME03800B (me) 2021-04-20
SG11201606108RA (en) 2016-08-30
RS60547B1 (sr) 2020-08-31
EA201691529A1 (ru) 2017-01-30
EP3348556B1 (en) 2020-04-29
US20160207912A1 (en) 2016-07-21
WO2015116663A8 (en) 2016-09-15
JP6619741B2 (ja) 2019-12-11
AP2016009347A0 (en) 2016-07-31
US10358443B2 (en) 2019-07-23
US9738635B2 (en) 2017-08-22
HRP20201107T1 (hr) 2020-10-30
SI3099684T1 (en) 2018-08-31
CR20160394A (es) 2016-11-01
HUE050964T2 (hu) 2021-01-28
BR122018001892B1 (pt) 2023-05-02
PE20161393A1 (es) 2017-01-08
JP2019163321A (ja) 2019-09-26
DK3348556T3 (da) 2020-08-03
PT3099684T (pt) 2018-10-22
WO2015116663A1 (en) 2015-08-06
CN111039939A (zh) 2020-04-21
CN111039939B (zh) 2023-09-19
AU2015211119A8 (en) 2016-12-15
LT3348556T (lt) 2020-08-10
KR102383038B1 (ko) 2022-04-05
CA2937967C (en) 2022-07-26
KR20160113287A (ko) 2016-09-28
EA032374B1 (ru) 2019-05-31
EP3099684B8 (en) 2018-07-04
PH12016501493A1 (en) 2017-02-06
EP3099684B1 (en) 2018-04-04
ZA201605246B (en) 2022-05-25
CA2937967A1 (en) 2015-08-06
EP3348556A1 (en) 2018-07-18
DK3099684T3 (en) 2018-07-16
AU2015211119B2 (en) 2019-05-30
AU2015211119A1 (en) 2016-08-11
MY187450A (en) 2021-09-22

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