UA118209C2 - Гетероариламіди як інгібітори агрегації білків - Google Patents
Гетероариламіди як інгібітори агрегації білківInfo
- Publication number
- UA118209C2 UA118209C2 UAA201609003A UAA201609003A UA118209C2 UA 118209 C2 UA118209 C2 UA 118209C2 UA A201609003 A UAA201609003 A UA A201609003A UA A201609003 A UAA201609003 A UA A201609003A UA 118209 C2 UA118209 C2 UA 118209C2
- Authority
- UA
- Ukraine
- Prior art keywords
- disease
- protein aggregation
- methods
- inhibitors
- parkinson
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Цей винахід стосується певних гетероариламідних сполук, фармацевтичних композицій, що їх містять, та способів їх застосування, у тому числі способів попереджання, купірування, уповільнення або інгібування агрегації білків, та способів лікування захворювань, пов'язаних з агрегацією білків, у тому числі нейродегенеративних захворювань, таких як хвороба Паркінсона, хвороба Альцгеймера, хвороба тілець Леві, хвороба Паркінсона з деменцією, лобно-скронева деменція, хвороба Гантінгтона, бічний аміотрофічний склероз та множинна системна атрофія, та раку і меланоми.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933246P | 2014-01-29 | 2014-01-29 | |
| US201462078895P | 2014-11-12 | 2014-11-12 | |
| PCT/US2015/013263 WO2015116663A1 (en) | 2014-01-29 | 2015-01-28 | Heteroarly amides as inhibitors of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA118209C2 true UA118209C2 (uk) | 2018-12-10 |
Family
ID=52484559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201609003A UA118209C2 (uk) | 2014-01-29 | 2015-01-28 | Гетероариламіди як інгібітори агрегації білків |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US9738635B2 (uk) |
| EP (2) | EP3348556B1 (uk) |
| JP (2) | JP6619741B2 (uk) |
| KR (1) | KR102383038B1 (uk) |
| CN (2) | CN111039939B (uk) |
| AP (1) | AP2016009347A0 (uk) |
| AU (1) | AU2015211119B2 (uk) |
| BR (2) | BR122018001892B1 (uk) |
| CA (1) | CA2937967C (uk) |
| CL (1) | CL2016001918A1 (uk) |
| CR (1) | CR20160394A (uk) |
| CY (2) | CY1120348T1 (uk) |
| DK (2) | DK3348556T3 (uk) |
| EA (1) | EA032374B1 (uk) |
| EC (1) | ECSP16070327A (uk) |
| ES (2) | ES2675301T3 (uk) |
| HK (1) | HK1231470A1 (uk) |
| HR (2) | HRP20180813T1 (uk) |
| HU (2) | HUE040274T2 (uk) |
| IL (1) | IL246987B (uk) |
| LT (2) | LT3348556T (uk) |
| ME (1) | ME03800B (uk) |
| MX (1) | MX2016009896A (uk) |
| MY (1) | MY187450A (uk) |
| NZ (1) | NZ722487A (uk) |
| PE (1) | PE20161393A1 (uk) |
| PH (1) | PH12016501493A1 (uk) |
| PL (2) | PL3348556T3 (uk) |
| PT (2) | PT3348556T (uk) |
| RS (2) | RS57533B1 (uk) |
| SA (1) | SA516371579B1 (uk) |
| SG (1) | SG11201606108RA (uk) |
| SI (2) | SI3099684T1 (uk) |
| TR (1) | TR201809440T4 (uk) |
| UA (1) | UA118209C2 (uk) |
| WO (1) | WO2015116663A1 (uk) |
| ZA (1) | ZA201605246B (uk) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3348556T3 (da) | 2014-01-29 | 2020-08-03 | UCB Biopharma SRL | Heteroarylamider som hæmmere af proteinaggregering |
| WO2017020010A1 (en) | 2015-07-29 | 2017-02-02 | Neuropore Therapies, Inc. | Bis-heteroaryl derivatives as modulators of protein aggregation |
| CN107625767A (zh) * | 2016-11-25 | 2018-01-26 | 刘淑兰 | 一种治疗慢性盆腔炎的药物 |
| US11091474B2 (en) * | 2017-01-26 | 2021-08-17 | UCB Biopharma SRL | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| MX2019007053A (es) * | 2017-01-26 | 2019-08-29 | Ucb Biopharma Sprl | Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas. |
| WO2018138088A1 (en) * | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation |
| AU2018265584B2 (en) * | 2017-05-12 | 2023-09-28 | Ludwig-Maximilians-Universität München | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
| US11505528B2 (en) | 2017-08-04 | 2022-11-22 | Axial Therapeutics, Inc. | Inhibitors of microbially induced amyloid |
| WO2019089640A1 (en) * | 2017-10-31 | 2019-05-09 | Loma Linda University | Methods for treating traumatic brain injury |
| WO2020041331A1 (en) | 2018-08-20 | 2020-02-27 | Arvinas Operations, Inc. | Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases |
| WO2023125376A1 (zh) * | 2021-12-27 | 2023-07-06 | 上海京新生物医药有限公司 | 作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物 |
| GB202213796D0 (en) * | 2022-09-21 | 2022-11-02 | Wista Lab Ltd | Tau aggregation inhibitors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997023202A1 (en) * | 1995-12-22 | 1997-07-03 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON | Subtype-selective nmda receptor ligands and the use thereof |
| MXPA05005547A (es) * | 2002-11-28 | 2005-07-26 | Schering Ag | Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos. |
| CN100536837C (zh) * | 2003-02-27 | 2009-09-09 | 乔安妮·麦克劳林 | 鲨肌醇在制备诊断试剂中的用途 |
| ES2284081T3 (es) * | 2003-12-19 | 2007-11-01 | Bristol-Myers Squibb Company | Heterociclos azabiciclicos como modulares de receptores canabinoides. |
| TW200530246A (en) * | 2003-12-19 | 2005-09-16 | Bristol Myers Squibb Co | Azabicyclic heterocycles as cannabinoid receptor modulators |
| KR20070018824A (ko) * | 2003-12-19 | 2007-02-14 | 브리스톨-마이어스 스큅 컴퍼니 | 카나비노이드 수용체 조절제인 아자비사이클릭헤테로사이클 |
| BRPI0513915A (pt) * | 2004-08-26 | 2008-05-20 | Pfizer | compostos aminoeteroarila enantiomericamente puros como inibidores de proteìna quinase |
| CA2580725A1 (en) * | 2004-09-20 | 2006-03-30 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| SE0403119D0 (sv) * | 2004-12-21 | 2004-12-21 | Astrazeneca Ab | Therapeutic agents |
| BRPI0615524A2 (pt) * | 2005-07-11 | 2010-04-06 | Devgen Nv | derivados da amida como inibidores da quinase |
| EA016300B1 (ru) * | 2005-07-29 | 2012-04-30 | 4ЭсЦэ АГ | НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB |
| KR20080104147A (ko) * | 2006-03-15 | 2008-12-01 | 4에스체 악티엔게젤샤프트 | 신규의 헤테로환 ＮＦ-κＢ 억제제 |
| CA2668744C (en) * | 2006-11-17 | 2015-09-15 | Queen's University At Kingston | Compounds and methods for treating protein folding disorders |
| US8450481B2 (en) * | 2007-06-14 | 2013-05-28 | The Regents Of The University Of California | Compounds for inhibiting protein aggregation, and methods for making and using them |
| US8598356B2 (en) * | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| JP2013508350A (ja) * | 2009-10-20 | 2013-03-07 | ファイザー・インク | ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール |
| WO2011084642A1 (en) * | 2009-12-16 | 2011-07-14 | Neuropore Therapies, Inc. | Compound suitable for the treatment of synucleopathies |
| GB201021103D0 (en) * | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| WO2013134371A1 (en) | 2012-03-06 | 2013-09-12 | Neuropore Therapies, Inc. | Methods and compounds to be used in the treatment of neurodegenerative diseases |
| JP6159388B2 (ja) | 2012-03-28 | 2017-07-05 | ニューロポア セラピーズ，インコーポレイティド | タンパク質凝集の阻害剤としてのフェニル−尿素及びフェニル−カルバメート誘導体 |
| US9284309B2 (en) * | 2012-07-16 | 2016-03-15 | Neuropore Therapies, Inc. | Di- and tri-heteroaryl derivatives as inhibitors of protein aggregation |
| DK3348556T3 (da) | 2014-01-29 | 2020-08-03 | UCB Biopharma SRL | Heteroarylamider som hæmmere af proteinaggregering |
| WO2017020010A1 (en) | 2015-07-29 | 2017-02-02 | Neuropore Therapies, Inc. | Bis-heteroaryl derivatives as modulators of protein aggregation |
| WO2018138088A1 (en) | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation |
| MX2019007053A (es) | 2017-01-26 | 2019-08-29 | Ucb Biopharma Sprl | Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas. |
-
2015
- 2015-01-28 DK DK18156929.4T patent/DK3348556T3/da active
- 2015-01-28 SI SI201530252T patent/SI3099684T1/en unknown
- 2015-01-28 ME MEP-2020-148A patent/ME03800B/me unknown
- 2015-01-28 AU AU2015211119A patent/AU2015211119B2/en active Active
- 2015-01-28 RS RS20180644A patent/RS57533B1/sr unknown
- 2015-01-28 JP JP2016549488A patent/JP6619741B2/ja active Active
- 2015-01-28 UA UAA201609003A patent/UA118209C2/uk unknown
- 2015-01-28 NZ NZ722487A patent/NZ722487A/en unknown
- 2015-01-28 HU HUE15705417A patent/HUE040274T2/hu unknown
- 2015-01-28 BR BR122018001892-5A patent/BR122018001892B1/pt active IP Right Grant
- 2015-01-28 PT PT181569294T patent/PT3348556T/pt unknown
- 2015-01-28 MX MX2016009896A patent/MX2016009896A/es active IP Right Grant
- 2015-01-28 PT PT15705417T patent/PT3099684T/pt unknown
- 2015-01-28 AP AP2016009347A patent/AP2016009347A0/en unknown
- 2015-01-28 EP EP18156929.4A patent/EP3348556B1/en active Active
- 2015-01-28 CR CR20160394A patent/CR20160394A/es unknown
- 2015-01-28 PL PL18156929T patent/PL3348556T3/pl unknown
- 2015-01-28 SG SG11201606108RA patent/SG11201606108RA/en unknown
- 2015-01-28 MY MYPI2016001401A patent/MY187450A/en unknown
- 2015-01-28 EP EP15705417.2A patent/EP3099684B8/en active Active
- 2015-01-28 DK DK15705417.2T patent/DK3099684T3/en active
- 2015-01-28 KR KR1020167023810A patent/KR102383038B1/ko active IP Right Grant
- 2015-01-28 ES ES15705417.2T patent/ES2675301T3/es active Active
- 2015-01-28 RS RS20200827A patent/RS60547B1/sr unknown
- 2015-01-28 CN CN201911278647.XA patent/CN111039939B/zh active Active
- 2015-01-28 BR BR112016017344-9A patent/BR112016017344B1/pt active IP Right Grant
- 2015-01-28 EA EA201691529A patent/EA032374B1/ru unknown
- 2015-01-28 ES ES18156929T patent/ES2808978T3/es active Active
- 2015-01-28 TR TR2018/09440T patent/TR201809440T4/tr unknown
- 2015-01-28 CN CN201580017216.1A patent/CN106132960B/zh active Active
- 2015-01-28 SI SI201531297T patent/SI3348556T1/sl unknown
- 2015-01-28 WO PCT/US2015/013263 patent/WO2015116663A1/en active Application Filing
- 2015-01-28 PE PE2016001285A patent/PE20161393A1/es unknown
- 2015-01-28 PL PL15705417T patent/PL3099684T3/pl unknown
- 2015-01-28 CA CA2937967A patent/CA2937967C/en active Active
- 2015-01-28 LT LTEP18156929.4T patent/LT3348556T/lt unknown
- 2015-01-28 LT LTEP15705417.2T patent/LT3099684T/lt unknown
- 2015-01-28 HU HUE18156929A patent/HUE050964T2/hu unknown
- 2015-12-29 US US14/983,243 patent/US9738635B2/en active Active
-
2016
- 2016-07-27 IL IL246987A patent/IL246987B/en unknown
- 2016-07-28 CL CL2016001918A patent/CL2016001918A1/es unknown
- 2016-07-28 ZA ZA2016/05246A patent/ZA201605246B/en unknown
- 2016-07-28 SA SA516371579A patent/SA516371579B1/ar unknown
- 2016-07-28 PH PH12016501493A patent/PH12016501493A1/en unknown
- 2016-08-29 EC ECIEPI201670327A patent/ECSP16070327A/es unknown
-
2017
- 2017-05-18 HK HK17105014.2A patent/HK1231470A1/zh unknown
- 2017-08-01 US US15/666,503 patent/US10358443B2/en active Active
-
2018
- 2018-05-24 HR HRP20180813TT patent/HRP20180813T1/hr unknown
- 2018-06-15 CY CY20181100630T patent/CY1120348T1/el unknown
-
2019
- 2019-06-04 JP JP2019104159A patent/JP6783900B2/ja active Active
- 2019-06-11 US US16/438,348 patent/US11078196B2/en active Active
-
2020
- 2020-07-14 HR HRP20201107TT patent/HRP20201107T8/hr unknown
- 2020-07-24 CY CY20201100682T patent/CY1123374T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016501493A1 (en) | Heteroaryl amides as inhibitors of protein aggregation | |
| MX2019008256A (es) | Derivados de bis-heteroarilo biciclicos como moduladores de agregacion de proteinas. | |
| MX2019007053A (es) | Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas. | |
| SG10201908028SA (en) | Cyclopropylamines as lsd1 inhibitors | |
| MX2019007243A (es) | Inhibidores de ectonucleotidasa y metodos de uso de los mismos. | |
| MX2015012056A (es) | Inhibidores de indolamina-2,3-dioxigenasa (ido). | |
| WO2015108490A3 (en) | Heteroaryl alkyne derivatives and uses thereof | |
| MX2015000618A (es) | Derivados de di- y tri-heteroarilo como inhibidores de la agregacion de proteinas. | |
| GEP20196961B (en) | 4-oxo-3,4-dihydro-1,2,3 -benzotriazines modulators of gpr139 | |
| PH12018500504A1 (en) | Compounds useful for inhibiting ror-gamma-t | |
| EP3773547A4 (en) | IDENTIFICATION OF GRANINES AS A PATHOGENIC FACTOR OF ALZHEIMER'S MORBUS AND COMPOSITIONS AND METHODS FOR INHIBITING GRANINE AGGREGATION AND TREATMENT OF ALZHEIMER'S MORBUS | |
| MY184878A (en) | Compositions and methods for treating neurodegenerative diseases | |
| MX2019001634A (es) | Compuestos amidas, composiciones farmacéuticas de estos y métodos para utilizarlos. | |
| MX2018001592A (es) | Composiciones y metodos para el tratamiento y la prevencion de trastornos neurodegenerativos. | |
| MX2019007054A (es) | Derivados de alcoxi bis-heteroarilo como moduladores de la agregacion de proteinas. | |
| EP3501524A4 (en) | USE OF PHYTOSPHINGOSINE-1-PHOSPHATE OR A DERIVATIVE THEREOF AS AN IMMUNE ACTIVATOR OR PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DEMENTIA | |
| PH12016502480A1 (en) | Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases | |
| MY182818A (en) | Compositions for the treatment of fibrosis and fibrosis-related conditions | |
| EP3628008A4 (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | |
| HK1246778A1 (zh) | 一種新型的3-氮雜雙環[3.1.0]己烷衍生物的鹽的晶體以及其醫藥應用 | |
| EP3518914A4 (en) | COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE AND PARKINSON'S DISEASE | |
| MA39227A1 (fr) | Amides hétéroaryles comme inhibiteurs de l'agrégation protéique | |
| EP3634979A4 (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | |
| AU2015904411A0 (en) | Compositions and methods for the treatment of Alzheimer's disease |