MX2019007054A - Derivados de alcoxi bis-heteroarilo como moduladores de la agregacion de proteinas. - Google Patents
Derivados de alcoxi bis-heteroarilo como moduladores de la agregacion de proteinas.Info
- Publication number
- MX2019007054A MX2019007054A MX2019007054A MX2019007054A MX2019007054A MX 2019007054 A MX2019007054 A MX 2019007054A MX 2019007054 A MX2019007054 A MX 2019007054A MX 2019007054 A MX2019007054 A MX 2019007054A MX 2019007054 A MX2019007054 A MX 2019007054A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- protein aggregation
- methods
- modulators
- heteroaryl derivatives
- Prior art date
Links
- 230000004845 protein aggregation Effects 0.000 title abstract 3
- 125000003545 alkoxy group Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a ciertos compuestos de bis-heteroarilo, a las composiciones farmacéuticas que los contienen y a los métodos para usarlos, incluidos los métodos para prevenir, revertir, desacelerar o inhibir la agregación de proteínas, y a los métodos para tratar enfermedades que están asociadas con la agregación de proteínas, incluyendo las enfermedades neurodegenerativas tales como la enfermedad de Parkinson, la enfermedad de Alzheimer, la enfermedad de los cuerpos de Lewy, la enfermedad de Parkinson con demencia, la demencia fronto-temporal, la enfermedad de Huntington, la esclerosis lateral amiotrófica, la atrofia multisistémica y el cáncer, incluido el melanoma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17153210 | 2017-01-26 | ||
| PCT/EP2018/051579 WO2018138085A1 (en) | 2017-01-26 | 2018-01-23 | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019007054A true MX2019007054A (es) | 2019-08-29 |
Family
ID=57906525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007054A MX2019007054A (es) | 2017-01-26 | 2018-01-23 | Derivados de alcoxi bis-heteroarilo como moduladores de la agregacion de proteinas. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11091474B2 (es) |
| EP (1) | EP3573981B1 (es) |
| JP (1) | JP7100042B2 (es) |
| KR (1) | KR20190112031A (es) |
| CN (1) | CN110191885B (es) |
| AU (1) | AU2018213886A1 (es) |
| BR (1) | BR112019011931A2 (es) |
| CA (1) | CA3048946A1 (es) |
| CL (1) | CL2019001750A1 (es) |
| CO (1) | CO2019007833A2 (es) |
| EA (1) | EA201991753A1 (es) |
| ES (1) | ES2918048T3 (es) |
| IL (1) | IL268003A (es) |
| MA (1) | MA47369A (es) |
| MX (1) | MX2019007054A (es) |
| RU (1) | RU2019126164A (es) |
| WO (1) | WO2018138085A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3048947A1 (en) * | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Bis-heteroaryl derivatives as modulators of protein aggregation |
| CN115677723B (zh) * | 2020-01-21 | 2024-06-04 | 瀚远医药有限公司 | 5-ht2a受体拮抗剂及其治疗中枢神经系统疾病的应用 |
| WO2023125376A1 (zh) * | 2021-12-27 | 2023-07-06 | 上海京新生物医药有限公司 | 作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| AU2010339841B2 (en) * | 2009-12-16 | 2014-09-25 | Neuropore Therapies, Inc. | Compound suitable for the treatment of synucleopathies |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| WO2013134371A1 (en) | 2012-03-06 | 2013-09-12 | Neuropore Therapies, Inc. | Methods and compounds to be used in the treatment of neurodegenerative diseases |
| EP2830608B8 (en) | 2012-03-28 | 2020-01-15 | UCB Biopharma SRL | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| JP2015522617A (ja) * | 2012-07-16 | 2015-08-06 | ニューロポア セラピーズ，インコーポレイティド | タンパク質凝集の阻害剤としてのジ−およびトリ−ヘテロアリール誘導体 |
| NZ722487A (en) * | 2014-01-29 | 2022-04-29 | Ucb Biopharma Sprl | Heteroaryl amides as inhibitors of protein aggregation |
| WO2017020010A1 (en) | 2015-07-29 | 2017-02-02 | Neuropore Therapies, Inc. | Bis-heteroaryl derivatives as modulators of protein aggregation |
| EP3573986B1 (en) | 2017-01-26 | 2021-05-26 | UCB Biopharma SRL | Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation |
| CA3048947A1 (en) | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Bis-heteroaryl derivatives as modulators of protein aggregation |
-
2018
- 2018-01-23 MA MA047369A patent/MA47369A/fr unknown
- 2018-01-23 RU RU2019126164A patent/RU2019126164A/ru not_active Application Discontinuation
- 2018-01-23 JP JP2019539261A patent/JP7100042B2/ja active Active
- 2018-01-23 BR BR112019011931-0A patent/BR112019011931A2/pt not_active Application Discontinuation
- 2018-01-23 WO PCT/EP2018/051579 patent/WO2018138085A1/en unknown
- 2018-01-23 EA EA201991753A patent/EA201991753A1/ru unknown
- 2018-01-23 EP EP18703235.4A patent/EP3573981B1/en active Active
- 2018-01-23 ES ES18703235T patent/ES2918048T3/es active Active
- 2018-01-23 KR KR1020197024618A patent/KR20190112031A/ko not_active Application Discontinuation
- 2018-01-23 AU AU2018213886A patent/AU2018213886A1/en not_active Abandoned
- 2018-01-23 CN CN201880006709.9A patent/CN110191885B/zh active Active
- 2018-01-23 US US16/480,251 patent/US11091474B2/en active Active
- 2018-01-23 MX MX2019007054A patent/MX2019007054A/es unknown
- 2018-01-23 CA CA3048946A patent/CA3048946A1/en active Pending
-
2019
- 2019-06-21 CL CL2019001750A patent/CL2019001750A1/es unknown
- 2019-07-11 IL IL268003A patent/IL268003A/en unknown
- 2019-07-22 CO CONC2019/0007833A patent/CO2019007833A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020505368A (ja) | 2020-02-20 |
| IL268003A (en) | 2019-09-26 |
| CA3048946A1 (en) | 2018-08-02 |
| US20200291013A1 (en) | 2020-09-17 |
| EP3573981A1 (en) | 2019-12-04 |
| MA47369A (fr) | 2019-12-04 |
| CO2019007833A2 (es) | 2019-08-20 |
| EP3573981B1 (en) | 2022-03-16 |
| US11091474B2 (en) | 2021-08-17 |
| WO2018138085A1 (en) | 2018-08-02 |
| RU2019126164A (ru) | 2021-02-26 |
| CN110191885B (zh) | 2023-05-16 |
| CL2019001750A1 (es) | 2019-11-22 |
| EA201991753A1 (ru) | 2020-01-14 |
| CN110191885A (zh) | 2019-08-30 |
| AU2018213886A1 (en) | 2019-07-25 |
| BR112019011931A2 (pt) | 2019-10-29 |
| KR20190112031A (ko) | 2019-10-02 |
| ES2918048T3 (es) | 2022-07-13 |
| JP7100042B2 (ja) | 2022-07-12 |
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