MX2020013853A - Compuestos innovadores. - Google Patents
Compuestos innovadores.Info
- Publication number
- MX2020013853A MX2020013853A MX2020013853A MX2020013853A MX2020013853A MX 2020013853 A MX2020013853 A MX 2020013853A MX 2020013853 A MX2020013853 A MX 2020013853A MX 2020013853 A MX2020013853 A MX 2020013853A MX 2020013853 A MX2020013853 A MX 2020013853A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- novel compounds
- compositions
- combinations
- antitrypsin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a compuestos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación. La invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos, por ejemplo, como moduladores de alfa 1 antitripsina y para el tratamiento de enfermedades asociadas con alfa antitripsina, particularmente enfermedades del hígado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1810290.5A GB201810290D0 (en) | 2018-06-22 | 2018-06-22 | Novel Compounds |
GBGB1906708.1A GB201906708D0 (en) | 2019-05-13 | 2019-05-13 | Novel compounds |
PCT/GB2019/051761 WO2019243841A1 (en) | 2018-06-22 | 2019-06-21 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020013853A true MX2020013853A (es) | 2021-05-27 |
Family
ID=67139769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020013853A MX2020013853A (es) | 2018-06-22 | 2019-06-21 | Compuestos innovadores. |
Country Status (10)
Country | Link |
---|---|
US (2) | US20210276952A1 (es) |
EP (1) | EP3810131A1 (es) |
CN (1) | CN113286586A (es) |
AU (1) | AU2019289228A1 (es) |
BR (1) | BR112020026314A2 (es) |
CA (1) | CA3103920A1 (es) |
IL (1) | IL279526A (es) |
MX (1) | MX2020013853A (es) |
SG (1) | SG11202012765PA (es) |
WO (1) | WO2019243841A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020081257A1 (en) | 2018-10-05 | 2020-04-23 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
US11884672B2 (en) | 2019-05-14 | 2024-01-30 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
GB201918404D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of aplha1-antitrypsin deficiency |
GB201918414D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
GB201918410D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
GB201918416D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
GB201918413D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
JP2023520400A (ja) * | 2020-04-03 | 2023-05-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ-1-アンチトリプシン欠損症(aatd)を治療するためのアルファ-1-アンチトリプシンモジュレーターとしてのインドール誘導体 |
AU2021247285A1 (en) * | 2020-04-03 | 2022-10-27 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
BR112022019794A2 (pt) * | 2020-04-03 | 2022-12-06 | Vertex Pharma | Derivados de pirrolo[2,3-f]indazol e 2,4,5,10-tetrazatriciclo[7.3.0.03,7]dodeca-1,3(7),5,8,11- penteno como moduladores da alfa-1-antitripsina para tratamento da deficiência de alfa-1-antitripsina (aatd) |
WO2021203028A1 (en) * | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
CA3178470A1 (en) * | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
GB202009074D0 (en) | 2020-06-15 | 2020-07-29 | Z Factor Ltd | Compound |
GB202108523D0 (en) | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compositions and their use for the treatment of alpha1-antitrypsin deficiency |
CN113801053B (zh) * | 2021-11-01 | 2023-09-08 | 上海皓鸿生物医药科技有限公司 | 一种制备7-氟-2-氧代吲哚啉-4-羧酸的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3818830A1 (de) * | 1988-06-03 | 1989-12-14 | Boehringer Mannheim Gmbh | Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel |
CA2156408C (en) | 1993-03-17 | 2005-02-15 | Daniel C. Duan | Aerosol formulation containing a polyester dispersing aid |
US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
US9801637B2 (en) | 2006-03-13 | 2017-10-31 | Pneumrx, Inc. | Genetically-associated chronic obstructive pulmonary disease treatment |
WO2008143633A2 (en) | 2007-01-10 | 2008-11-27 | University Of Florida | Compounds and methods for treatment of alpha-1 antitrypsin deficiency |
KR101402702B1 (ko) | 2011-09-15 | 2014-06-05 | (주)알테오젠 | 신규한 알파-1 안티트립신 변이체, 이의 제조방법 및 용도 |
CN107849084B (zh) * | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
CN113801053B (zh) | 2021-11-01 | 2023-09-08 | 上海皓鸿生物医药科技有限公司 | 一种制备7-氟-2-氧代吲哚啉-4-羧酸的方法 |
-
2019
- 2019-06-21 SG SG11202012765PA patent/SG11202012765PA/en unknown
- 2019-06-21 BR BR112020026314-1A patent/BR112020026314A2/pt unknown
- 2019-06-21 US US17/254,854 patent/US20210276952A1/en not_active Abandoned
- 2019-06-21 MX MX2020013853A patent/MX2020013853A/es unknown
- 2019-06-21 CN CN201980054648.8A patent/CN113286586A/zh active Pending
- 2019-06-21 EP EP19735375.8A patent/EP3810131A1/en active Pending
- 2019-06-21 AU AU2019289228A patent/AU2019289228A1/en active Pending
- 2019-06-21 WO PCT/GB2019/051761 patent/WO2019243841A1/en unknown
- 2019-06-21 CA CA3103920A patent/CA3103920A1/en active Pending
-
2020
- 2020-12-17 IL IL279526A patent/IL279526A/en unknown
-
2022
- 2022-06-23 US US17/848,156 patent/US11919856B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN113286586A (zh) | 2021-08-20 |
CA3103920A1 (en) | 2019-12-26 |
WO2019243841A1 (en) | 2019-12-26 |
US20210276952A1 (en) | 2021-09-09 |
AU2019289228A1 (en) | 2021-01-21 |
BR112020026314A2 (pt) | 2021-03-30 |
EP3810131A1 (en) | 2021-04-28 |
US11919856B2 (en) | 2024-03-05 |
SG11202012765PA (en) | 2021-01-28 |
IL279526A (en) | 2021-01-31 |
US20220340525A1 (en) | 2022-10-27 |
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