MX2017016231A - Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. - Google Patents

Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina.

Info

Publication number
MX2017016231A
MX2017016231A MX2017016231A MX2017016231A MX2017016231A MX 2017016231 A MX2017016231 A MX 2017016231A MX 2017016231 A MX2017016231 A MX 2017016231A MX 2017016231 A MX2017016231 A MX 2017016231A MX 2017016231 A MX2017016231 A MX 2017016231A
Authority
MX
Mexico
Prior art keywords
agonists
compounds
nicotinic acetylcholine
methods
acetylcholine receptors
Prior art date
Application number
MX2017016231A
Other languages
English (en)
Inventor
Gregory Bursavich Matthew
alden harrison Bryce
ACHARYA Raksha
Simon Cook Andrew
J Mcriner Andrew
A Burnett Duane
Original Assignee
Axovant Sciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axovant Sciences Gmbh filed Critical Axovant Sciences Gmbh
Publication of MX2017016231A publication Critical patent/MX2017016231A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a novedosos compuestos de aminobencisoxazol, y composiciones farmacéuticas de los mismos, que son adecuados como agonistas o agonistas parciales de ot7-nAChR, y métodos de preparación de estos compuestos y composiciones, y al uso de estos compuestos y composiciones en métodos de mantenimiento, tratamiento y/o mejora de la función cognitiva. En particular, métodos de administración del compuesto o composición a un paciente en necesidad del mismo, por ejemplo un paciente con una deficiencia cognitiva y/o un deseo de potenciar la función cognitiva, que pueda obtener un beneficio del mismo.
MX2017016231A 2015-06-10 2016-06-09 Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. MX2017016231A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173717P 2015-06-10 2015-06-10
PCT/US2016/036689 WO2016201096A1 (en) 2015-06-10 2016-06-09 Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors

Publications (1)

Publication Number Publication Date
MX2017016231A true MX2017016231A (es) 2018-11-29

Family

ID=57503923

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016231A MX2017016231A (es) 2015-06-10 2016-06-09 Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina.

Country Status (13)

Country Link
US (1) US10370370B2 (es)
EP (1) EP3307269A4 (es)
JP (1) JP2018516973A (es)
KR (1) KR20180044256A (es)
CN (1) CN107847494A (es)
AU (1) AU2016274694A1 (es)
CA (1) CA2988968A1 (es)
HK (1) HK1246184A1 (es)
IL (1) IL256226A (es)
MX (1) MX2017016231A (es)
NO (1) NO20180002A1 (es)
RU (1) RU2017145964A (es)
WO (1) WO2016201096A1 (es)

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CN110551147B (zh) * 2019-09-29 2021-11-26 蚌埠产品质量监督检验研究院 一种3-环丙基苯硼酸的合成方法
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US20180134696A1 (en) 2018-05-17
WO2016201096A1 (en) 2016-12-15
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EP3307269A1 (en) 2018-04-18
AU2016274694A1 (en) 2018-01-18
US10370370B2 (en) 2019-08-06
HK1246184A1 (zh) 2018-09-07
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IL256226A (en) 2018-02-28
CN107847494A (zh) 2018-03-27

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