ES2643056T3 - Piridina-2-amidas útiles como agonistas de cb2 - Google Patents
Piridina-2-amidas útiles como agonistas de cb2 Download PDFInfo
- Publication number
- ES2643056T3 ES2643056T3 ES13799543T ES13799543T ES2643056T3 ES 2643056 T3 ES2643056 T3 ES 2643056T3 ES 13799543 T ES13799543 T ES 13799543T ES 13799543 T ES13799543 T ES 13799543T ES 2643056 T3 ES2643056 T3 ES 2643056T3
- Authority
- ES
- Spain
- Prior art keywords
- agonists
- pyridine
- amides useful
- amides
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HAHJVZXJLKMSEE-IHBJSSOOSA-N C[C@@H](C(F)(F)F)Oc1cc(C(NC(C)(C2CC2)c2n[o]c(C)n2)=O)ncc1C1=CC1 Chemical compound C[C@@H](C(F)(F)F)Oc1cc(C(NC(C)(C2CC2)c2n[o]c(C)n2)=O)ncc1C1=CC1 HAHJVZXJLKMSEE-IHBJSSOOSA-N 0.000 description 1
- VUVMQFRHLXTLHC-IBGZPJMESA-N C[C@](CC1CC1)(c1n[o]c(C)n1)NC(c1ncc(C2CC2)c(OCC(F)(F)F)c1)=O Chemical compound C[C@](CC1CC1)(c1n[o]c(C)n1)NC(c1ncc(C2CC2)c(OCC(F)(F)F)c1)=O VUVMQFRHLXTLHC-IBGZPJMESA-N 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12196029 | 2012-12-07 | ||
PCT/EP2013/075442 WO2014086805A1 (en) | 2012-12-07 | 2013-12-04 | Pyridine-2-amides useful as cb2 agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2643056T3 true ES2643056T3 (es) | 2017-11-21 |
Family
ID=47290807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13799543T Active ES2643056T3 (es) | 2012-12-07 | 2013-12-04 | Piridina-2-amidas útiles como agonistas de cb2 |
Country Status (34)
Country | Link |
---|---|
US (1) | US9409866B2 (es) |
EP (1) | EP2928867B1 (es) |
JP (1) | JP6280132B2 (es) |
KR (1) | KR20150092232A (es) |
CN (1) | CN104837818B (es) |
AR (1) | AR093805A1 (es) |
AU (1) | AU2013354113B2 (es) |
BR (1) | BR112015013124A2 (es) |
CA (1) | CA2890353A1 (es) |
CL (1) | CL2015001537A1 (es) |
CO (1) | CO7350652A2 (es) |
CR (1) | CR20150277A (es) |
DK (1) | DK2928867T3 (es) |
EA (1) | EA027780B1 (es) |
ES (1) | ES2643056T3 (es) |
HK (1) | HK1210147A1 (es) |
HR (1) | HRP20171459T1 (es) |
HU (1) | HUE033898T2 (es) |
IL (1) | IL239074B (es) |
LT (1) | LT2928867T (es) |
MA (1) | MA38238B1 (es) |
MX (1) | MX2015007156A (es) |
MY (1) | MY179412A (es) |
PE (1) | PE20151073A1 (es) |
PH (1) | PH12015501082B1 (es) |
PL (1) | PL2928867T3 (es) |
PT (1) | PT2928867T (es) |
RS (1) | RS56424B1 (es) |
SG (1) | SG11201504475QA (es) |
SI (1) | SI2928867T1 (es) |
TW (1) | TWI629263B (es) |
UA (1) | UA114657C2 (es) |
WO (1) | WO2014086805A1 (es) |
ZA (1) | ZA201503600B (es) |
Families Citing this family (21)
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PL2964646T3 (pl) | 2013-03-07 | 2017-09-29 | F.Hoffmann-La Roche Ag | Nowe pochodne pirazolu |
BR112015024272A2 (pt) | 2013-03-26 | 2017-07-18 | Hoffmann La Roche | novos derivados de piridina |
LT2991988T (lt) | 2013-05-02 | 2017-08-10 | F. Hoffmann-La Roche Ag | Pirol[2,3-d]pirimidino dariniai kaip cb2 receptorių agonistai |
ES2680935T3 (es) | 2013-05-02 | 2018-09-11 | F. Hoffmann-La Roche Ag | Derivados de purina como agonistas del receptor CB2 |
HUE041760T2 (hu) | 2013-09-06 | 2019-05-28 | Hoffmann La Roche | Triazolo[4,5-d]pirimidin-származékok mint CBb2-receptor antagonisták |
JP6759100B2 (ja) * | 2013-12-30 | 2020-09-23 | ライフサイ ファーマシューティカルズ,インク. | 治療用阻害化合物 |
US9611252B2 (en) | 2013-12-30 | 2017-04-04 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
EP3156397B1 (en) * | 2014-06-13 | 2019-08-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
JP6951970B2 (ja) * | 2014-07-16 | 2021-10-20 | ライフサイ ファーマシューティカルズ,インク. | 治療用阻害化合物 |
WO2016009297A1 (en) * | 2014-07-18 | 2016-01-21 | Pfizer Inc. | Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators |
JP6836996B2 (ja) | 2015-02-25 | 2021-03-03 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新しいトリフルオロメチルプロパンアミド誘導体 |
CR20180298A (es) * | 2015-12-09 | 2018-07-18 | Hoffmann La Roche | Nuevos derivados de fenilo |
WO2018011628A1 (en) | 2016-07-11 | 2018-01-18 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
GB201703282D0 (en) * | 2017-03-01 | 2017-04-12 | Glaxosmithkline Intellectual Property (No 2) Ltd | Compounds |
EP3642200B1 (en) | 2017-06-20 | 2023-05-03 | F. Hoffmann-La Roche AG | Pyridine derivatives |
PE20210368A1 (es) | 2018-06-27 | 2021-02-26 | Eth Zuerich | Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2 |
WO2020002270A1 (en) | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists |
CN112638430B (zh) | 2018-06-27 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 放射性标记的大麻素受体2配体 |
BR112021000486A2 (pt) | 2018-08-01 | 2021-04-06 | Basilea Pharmaceutica International AG | Métodos para purificar sulfato de isavuconazônio |
EP4271383A4 (en) * | 2020-12-29 | 2024-10-23 | Merck Sharp & Dohme Llc | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES |
CN117800894A (zh) * | 2022-09-30 | 2024-04-02 | 苏州阿尔脉生物科技有限公司 | 饱和环类衍生物、包含其的药物组合物及其医药用途 |
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EP2076499B1 (en) * | 2006-10-04 | 2010-05-12 | F.Hoffmann-La Roche Ag | Pyrazine-2-carboxamide derivatives as cb2 receptor modulators |
KR20110063438A (ko) * | 2008-09-25 | 2011-06-10 | 베링거 인겔하임 인터내셔날 게엠베하 | Cb2 수용체를 선택적으로 조절하는 설포닐 화합물 |
WO2012031817A1 (en) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
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