ECSP11011541A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Info

Publication number
ECSP11011541A
ECSP11011541A EC2011011541A ECSP11011541A ECSP11011541A EC SP11011541 A ECSP11011541 A EC SP11011541A EC 2011011541 A EC2011011541 A EC 2011011541A EC SP11011541 A ECSP11011541 A EC SP11011541A EC SP11011541 A ECSP11011541 A EC SP11011541A
Authority
EC
Ecuador
Prior art keywords
antagonists
hedgehog
ftalazina
disttituted
trajectory
Prior art date
Application number
EC2011011541A
Other languages
English (en)
Inventor
Philip Arthur Hipskind
Takako Wilson
Bharvin Kumar Patel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP11011541A publication Critical patent/ECSP11011541A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención proporciona nuevos antagonistas de la trayectoria de hedgehog de ftalazina 1,4-disustituida útiles en el tratamiento de cáncer.
EC2011011541A 2009-06-19 2011-12-16 Antagonistas de la trayectoria hedgehog de ftalazina disustituida ECSP11011541A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21862809P 2009-06-19 2009-06-19

Publications (1)

Publication Number Publication Date
ECSP11011541A true ECSP11011541A (es) 2012-01-31

Family

ID=42332981

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011541A ECSP11011541A (es) 2009-06-19 2011-12-16 Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Country Status (36)

Country Link
US (2) US8273742B2 (es)
EP (1) EP2443104B1 (es)
JP (1) JP5596139B2 (es)
KR (1) KR101389165B1 (es)
CN (1) CN102459233B (es)
AR (1) AR077014A1 (es)
AU (1) AU2010260244B2 (es)
BR (1) BRPI1011601A2 (es)
CA (1) CA2764542C (es)
CL (1) CL2011003147A1 (es)
CO (1) CO6480932A2 (es)
CR (1) CR20110658A (es)
DK (1) DK2443104T3 (es)
DO (1) DOP2011000386A (es)
EA (1) EA019059B1 (es)
EC (1) ECSP11011541A (es)
ES (1) ES2409054T3 (es)
HK (1) HK1164872A1 (es)
HN (1) HN2011003139A (es)
HR (1) HRP20130408T1 (es)
IL (1) IL216599A (es)
JO (1) JO2931B1 (es)
MA (1) MA33363B1 (es)
MX (1) MX2011014029A (es)
MY (1) MY156667A (es)
NZ (1) NZ596882A (es)
PE (1) PE20121050A1 (es)
PL (1) PL2443104T3 (es)
PT (1) PT2443104E (es)
SG (1) SG177289A1 (es)
SI (1) SI2443104T1 (es)
TN (1) TN2011000627A1 (es)
TW (1) TWI385165B (es)
UA (1) UA106755C2 (es)
WO (1) WO2010147917A1 (es)
ZA (1) ZA201108587B (es)

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BRPI0911618A2 (pt) * 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
SI2364185T1 (sl) * 2008-11-03 2013-07-31 Eli Lilly And Company Disubstituirani ftalazini kot antagonisti signalne poti hedgehog
ES2446307T3 (es) * 2008-11-17 2014-03-07 Eli Lilly And Company Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
JP5518887B2 (ja) 2008-11-17 2014-06-11 イーライ リリー アンド カンパニー 四置換ピリダジンヘッジホッグ経路アンタゴニスト
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2012127441A1 (en) 2011-03-23 2012-09-27 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB201311953D0 (en) * 2013-07-03 2013-08-14 Redx Pharma Ltd Compounds
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105017140B (zh) * 2014-04-28 2017-12-29 复旦大学 邻氨基苯甲酰胺化合物及其制备方法和用途
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
US10369147B2 (en) 2015-06-04 2019-08-06 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
AU2016271432A1 (en) * 2015-06-05 2017-12-07 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
EA201892075A1 (ru) 2016-03-15 2019-04-30 Оризон Дженомикс, С.А. Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
CN106279114B (zh) * 2016-08-04 2019-01-29 东南大学 一种Taladegib的合成方法
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN106831718B (zh) * 2016-12-30 2019-05-07 上海科技大学 平滑受体配体及其应用
EP3624798A1 (en) 2017-05-18 2020-03-25 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for the treatment of mast cell diseases
TW202216133A (zh) 2020-06-26 2022-05-01 日商拉夸里亞創藥股份有限公司 類視色素與癌症治療藥之併用療法有效之癌症患者之選擇方法及類視色素與癌症治療藥之併用醫藥
EP4229828A1 (en) * 2020-10-13 2023-08-23 Endeavor Biomedicines, Inc. Methods of treating fibrosis

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IN148482B (es) * 1977-06-03 1981-03-07 Pfizer
WO1997026258A1 (en) 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
IL138645A0 (en) 1998-04-09 2001-10-31 Univ Johns Hopkins Med Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways
EP1183040B1 (en) 1999-06-08 2004-12-01 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog signalling pathway
MXPA04000803A (es) * 2001-07-27 2004-05-21 Curis Inc Mediadores de rutas de senalizacion de hedgehog, composiciones y usos relacionados a los mismos.
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BRPI0911618A2 (pt) * 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
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EP2321298B1 (en) * 2008-08-04 2013-10-02 Amgen Inc. Aurora kinase modulators and methods of use
SI2364185T1 (sl) 2008-11-03 2013-07-31 Eli Lilly And Company Disubstituirani ftalazini kot antagonisti signalne poti hedgehog
ES2446307T3 (es) 2008-11-17 2014-03-07 Eli Lilly And Company Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
JP5518887B2 (ja) 2008-11-17 2014-06-11 イーライ リリー アンド カンパニー 四置換ピリダジンヘッジホッグ経路アンタゴニスト
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
MX2011014029A (es) 2012-02-21
BRPI1011601A2 (pt) 2016-03-22
MY156667A (en) 2016-03-15
US20100324048A1 (en) 2010-12-23
AU2010260244A1 (en) 2012-01-19
TWI385165B (zh) 2013-02-11
US8273742B2 (en) 2012-09-25
DK2443104T3 (da) 2013-05-06
KR101389165B1 (ko) 2014-04-24
HRP20130408T1 (en) 2013-06-30
EP2443104A1 (en) 2012-04-25
ZA201108587B (en) 2013-05-29
CL2011003147A1 (es) 2012-07-20
IL216599A (en) 2015-09-24
DOP2011000386A (es) 2012-02-29
SI2443104T1 (sl) 2013-07-31
JO2931B1 (en) 2015-09-15
IL216599A0 (en) 2012-03-01
CN102459233A (zh) 2012-05-16
CO6480932A2 (es) 2012-07-16
CN102459233B (zh) 2014-07-02
UA106755C2 (uk) 2014-10-10
CA2764542C (en) 2013-09-10
EP2443104B1 (en) 2013-04-17
CA2764542A1 (en) 2010-12-23
SG177289A1 (en) 2012-02-28
TW201113268A (en) 2011-04-16
EA201270049A1 (ru) 2012-05-30
CR20110658A (es) 2012-02-20
MA33363B1 (fr) 2012-06-01
KR20120024783A (ko) 2012-03-14
TN2011000627A1 (en) 2013-05-24
HN2011003139A (es) 2013-07-29
JP5596139B2 (ja) 2014-09-24
PL2443104T3 (pl) 2013-08-30
AU2010260244B2 (en) 2013-09-05
PT2443104E (pt) 2013-05-07
WO2010147917A1 (en) 2010-12-23
NZ596882A (en) 2013-08-30
US9000023B2 (en) 2015-04-07
EA019059B1 (ru) 2013-12-30
US20120316174A1 (en) 2012-12-13
ES2409054T3 (es) 2013-06-24
PE20121050A1 (es) 2012-08-09
AR077014A1 (es) 2011-07-27
HK1164872A1 (en) 2012-09-28
JP2012530705A (ja) 2012-12-06

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