MA30394B1 - Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p - Google Patents

Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p

Info

Publication number
MA30394B1
MA30394B1 MA31347A MA31347A MA30394B1 MA 30394 B1 MA30394 B1 MA 30394B1 MA 31347 A MA31347 A MA 31347A MA 31347 A MA31347 A MA 31347A MA 30394 B1 MA30394 B1 MA 30394B1
Authority
MA
Morocco
Prior art keywords
synthesis
substance
acylaminoalcenylene
agonists
amides
Prior art date
Application number
MA31347A
Other languages
English (en)
Inventor
Robert Portmann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607532A external-priority patent/GB0607532D0/en
Priority claimed from GB0610244A external-priority patent/GB0610244D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30394B1 publication Critical patent/MA30394B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN PROCÉDÉ DE SYNTHÈSE DE COMPOSÉS DE FORMULE (I) OU DE SOLVATES OU HYDRATES DESDITS COMPOSÉS, R, R1, R2, R3 ET R5 AYANT LES VALEURS DÉFINIES DANS LA DESCRIPTION DE L'INVENTION. DE TELS COMPOSÉS PEUVENT ÊTRE EMPLOYÉS DANS LE TRAITEMENT DE PLUSIEURS ÉTATS PATHOLOGIQUES ASSOCIÉS À LA SUBSTANCE P ET À LA NEUROKININE.
MA31347A 2006-04-13 2008-11-03 Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p MA30394B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0607532A GB0607532D0 (en) 2006-04-13 2006-04-13 Organic compounds
GB0610244A GB0610244D0 (en) 2006-05-23 2006-05-23 Organic compounds

Publications (1)

Publication Number Publication Date
MA30394B1 true MA30394B1 (fr) 2009-05-04

Family

ID=38324102

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31347A MA30394B1 (fr) 2006-04-13 2008-11-03 Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p

Country Status (29)

Country Link
US (2) US8008479B2 (fr)
EP (1) EP2010498B1 (fr)
JP (1) JP5208917B2 (fr)
KR (1) KR20080108291A (fr)
AR (1) AR060506A1 (fr)
AT (1) ATE486853T1 (fr)
AU (1) AU2007237482B2 (fr)
CA (1) CA2645362C (fr)
CL (1) CL2007001040A1 (fr)
CY (1) CY1111294T1 (fr)
DE (1) DE602007010269D1 (fr)
DK (1) DK2010498T3 (fr)
EC (1) ECSP088820A (fr)
GT (1) GT200800209A (fr)
HK (1) HK1125640A1 (fr)
HR (1) HRP20110045T1 (fr)
JO (1) JO2630B1 (fr)
MA (1) MA30394B1 (fr)
MX (1) MX2008013117A (fr)
MY (1) MY145069A (fr)
NO (1) NO20084783L (fr)
NZ (1) NZ571142A (fr)
PE (1) PE20071223A1 (fr)
PL (1) PL2010498T3 (fr)
PT (1) PT2010498E (fr)
RU (1) RU2433122C2 (fr)
SI (1) SI2010498T1 (fr)
TW (1) TW200815358A (fr)
WO (1) WO2007118651A1 (fr)

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Also Published As

Publication number Publication date
TW200815358A (en) 2008-04-01
CA2645362C (fr) 2013-07-16
GT200800209A (es) 2008-12-15
SI2010498T1 (sl) 2011-03-31
EP2010498B1 (fr) 2010-11-03
AU2007237482A1 (en) 2007-10-25
JP2009533369A (ja) 2009-09-17
HRP20110045T1 (hr) 2011-02-28
RU2008145102A (ru) 2010-05-27
PL2010498T3 (pl) 2011-04-29
DE602007010269D1 (de) 2010-12-16
PT2010498E (pt) 2011-02-08
HK1125640A1 (en) 2009-08-14
KR20080108291A (ko) 2008-12-12
AR060506A1 (es) 2008-06-25
US20090137797A1 (en) 2009-05-28
AU2007237482B2 (en) 2011-03-17
RU2433122C2 (ru) 2011-11-10
JP5208917B2 (ja) 2013-06-12
JO2630B1 (en) 2012-06-17
DK2010498T3 (da) 2011-02-14
WO2007118651A1 (fr) 2007-10-25
MX2008013117A (es) 2008-10-21
US8008479B2 (en) 2011-08-30
US20110282053A1 (en) 2011-11-17
NO20084783L (no) 2008-11-12
ECSP088820A (es) 2008-11-27
NZ571142A (en) 2011-02-25
EP2010498A1 (fr) 2009-01-07
CY1111294T1 (el) 2015-08-05
CL2007001040A1 (es) 2008-03-14
CA2645362A1 (fr) 2007-10-25
PE20071223A1 (es) 2008-01-22
ATE486853T1 (de) 2010-11-15
MY145069A (en) 2011-12-15

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