ATE460425T1 - Histondeacetylaseinhibitor und verfahren zu dessen herstellung - Google Patents

Histondeacetylaseinhibitor und verfahren zu dessen herstellung

Info

Publication number
ATE460425T1
ATE460425T1 AT04746393T AT04746393T ATE460425T1 AT E460425 T1 ATE460425 T1 AT E460425T1 AT 04746393 T AT04746393 T AT 04746393T AT 04746393 T AT04746393 T AT 04746393T AT E460425 T1 ATE460425 T1 AT E460425T1
Authority
AT
Austria
Prior art keywords
compounds
production
histone deacetylase
deacetylase inhibitor
present
Prior art date
Application number
AT04746393T
Other languages
English (en)
Inventor
Minoru Yoshida
Norikazu Nishino
Original Assignee
Riken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken filed Critical Riken
Application granted granted Critical
Publication of ATE460425T1 publication Critical patent/ATE460425T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
AT04746393T 2003-06-20 2004-06-18 Histondeacetylaseinhibitor und verfahren zu dessen herstellung ATE460425T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003177298 2003-06-20
PCT/JP2004/008924 WO2004113366A1 (ja) 2003-06-20 2004-06-18 ヒストン脱アセチル化酵素阻害剤およびその製造方法

Publications (1)

Publication Number Publication Date
ATE460425T1 true ATE460425T1 (de) 2010-03-15

Family

ID=33534930

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04746393T ATE460425T1 (de) 2003-06-20 2004-06-18 Histondeacetylaseinhibitor und verfahren zu dessen herstellung

Country Status (6)

Country Link
US (1) US7662778B2 (de)
EP (1) EP1640380B1 (de)
JP (1) JP4550738B2 (de)
AT (1) ATE460425T1 (de)
DE (1) DE602004025935D1 (de)
WO (1) WO2004113366A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4274946B2 (ja) * 2002-02-20 2009-06-10 国立大学法人九州工業大学 ヒストン脱アセチル化酵素阻害剤およびその製造方法
JP2007262058A (ja) * 2006-03-03 2007-10-11 Tokyo Univ Of Science 糸状菌の分化抑制剤
US8158587B2 (en) 2006-09-05 2012-04-17 Kyushu Institute Of Technology Compound having histone deacetylase-inhibiting activity, and pharmaceutical composition comprising the compound as an active ingredient
JP5756290B2 (ja) * 2007-09-09 2015-07-29 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 大環状化合物および治療方法
US8293513B2 (en) * 2007-12-14 2012-10-23 Georgetown University Histone deacetylase inhibitors
US20110123644A1 (en) * 2008-04-11 2011-05-26 University Of Florida Research Foundation Macrocyclic compounds and methods of treatment
US9874565B2 (en) * 2013-06-21 2018-01-23 Dana-Farber Cancer Institute, Inc. Oncogene associated with human cancers and methods of use thereof
CN109912686B (zh) * 2019-03-13 2022-07-05 北京大学深圳研究生院 一种靶向hdac的稳定多肽类抑制剂及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922837A (en) * 1995-09-20 1999-07-13 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
KR20010023449A (ko) * 1997-09-02 2001-03-26 나가시마 카쭈시게, 노미야마 아키히코 신규한 환상 테트라펩티드 유도체 및 그 의약 용도
JPH11130795A (ja) 1997-10-29 1999-05-18 Yamanouchi Pharmaceut Co Ltd Ｙｍ−１７５２０１物質
EP1123309A2 (de) 1998-10-13 2001-08-16 Fujisawa Pharmaceutical Co., Ltd. Zyklische tetrapeptide und deren verwendung als histone deacetylase inhibitoren
JP4269041B2 (ja) 1999-03-02 2009-05-27 国立大学法人九州工業大学 新規な環状テトラペプチド誘導体とその医薬用途
WO2001007042A1 (en) 1999-07-23 2001-02-01 Merck & Co., Inc. Apicidin-derived cyclic tetrapeptides
US20030078369A1 (en) * 1999-07-23 2003-04-24 Meinke Peter T. Apicidin-derived cyclic tetrapeptides
CA2317003A1 (en) 2000-02-28 2001-08-28 Hidenori Nakajima Gene expression potentiator
JP2001316283A (ja) 2000-02-28 2001-11-13 Yasushi Kaneda 遺伝子発現増強剤
US20060229236A1 (en) 2001-12-28 2006-10-12 Fujisawa Pharmaceutical Co. Ltd. Cyclic tetrapeptide compound and use thereof
JP4274946B2 (ja) 2002-02-20 2009-06-10 国立大学法人九州工業大学 ヒストン脱アセチル化酵素阻害剤およびその製造方法

Also Published As

Publication number Publication date
EP1640380A4 (de) 2006-08-23
WO2004113366A1 (ja) 2004-12-29
EP1640380A1 (de) 2006-03-29
EP1640380B1 (de) 2010-03-10
JP4550738B2 (ja) 2010-09-22
JPWO2004113366A1 (ja) 2007-09-20
DE602004025935D1 (de) 2010-04-22
US7662778B2 (en) 2010-02-16
US20070185071A1 (en) 2007-08-09

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ATE460425T1 (de) Histondeacetylaseinhibitor und verfahren zu dessen herstellung

Legal Events

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