EA200500342A1 - Гетероциклические замещённые пиперазины для лечения шизофрении - Google Patents

Гетероциклические замещённые пиперазины для лечения шизофрении

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Publication number
EA200500342A1
EA200500342A1 EA200500342A EA200500342A EA200500342A1 EA 200500342 A1 EA200500342 A1 EA 200500342A1 EA 200500342 A EA200500342 A EA 200500342A EA 200500342 A EA200500342 A EA 200500342A EA 200500342 A1 EA200500342 A1 EA 200500342A1
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Eurasian Patent Office
Prior art keywords
treatment
piperasines
schizophrenia
heterocyclic substituted
disorders
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EA200500342A
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English (en)
Inventor
Тоня Линн Андриана
Стивен Санг Йонг Чоу
Джеймс Майкл Грэм
Трэйси Фэй Грегори
Гарри Ральф мл. Хауард
Брайан Эдвард Корнберг
Шам Шридхар Никам
Дерек Эндрю Пфлам
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УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
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Publication of EA200500342A1 publication Critical patent/EA200500342A1/ru

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Abstract

Данное изобретение относится к соединениям формулы 1, где X, Y, Z, A, R1, R2, R3, R4, R9, W1 и W2 такие, как они определены в описании изобретения, к фармацевтическим композициям, содержащим их, и к их применению в лечении заболеваний центральной нервной системы и других расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500342A 2002-09-17 2003-09-05 Гетероциклические замещённые пиперазины для лечения шизофрении EA200500342A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41147502P 2002-09-17 2002-09-17
US41635502P 2002-10-04 2002-10-04
PCT/IB2003/003902 WO2004026864A1 (en) 2002-09-17 2003-09-05 Heterocyclic substituted piperazines for the treatment of schizophrenia

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EA200500342A1 true EA200500342A1 (ru) 2005-08-25

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US (1) US20040138230A1 (ru)
EP (1) EP1546143A1 (ru)
JP (1) JP2006503106A (ru)
KR (1) KR20050057404A (ru)
AP (1) AP2005003250A0 (ru)
AR (1) AR041260A1 (ru)
AU (1) AU2003263413A1 (ru)
BR (1) BR0314393A (ru)
CA (1) CA2499326A1 (ru)
CO (1) CO5550472A2 (ru)
EA (1) EA200500342A1 (ru)
EC (1) ECSP055676A (ru)
HR (1) HRP20050248A2 (ru)
IS (1) IS7710A (ru)
MA (1) MA27438A1 (ru)
MX (1) MXPA05002007A (ru)
NO (1) NO20051826L (ru)
OA (1) OA12923A (ru)
PA (1) PA8582601A1 (ru)
PE (1) PE20050132A1 (ru)
PL (1) PL375981A1 (ru)
RS (1) RS20050195A (ru)
TW (1) TW200409771A (ru)
UY (1) UY27976A1 (ru)
WO (1) WO2004026864A1 (ru)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316108A (pt) * 2002-11-08 2005-09-27 Warner Lambert Co Derivados de fenilalquil e piridilalquil piperazina e composição farmacêutica compreendendo os mesmos
EP1697334A1 (en) * 2003-12-08 2006-09-06 Warner-Lambert Company LLC Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia
EP1701954A1 (en) * 2003-12-31 2006-09-20 Warner-Lambert Company LLC N-substituted piperidine and piperazine derivatives
US20050256118A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
WO2006090273A2 (en) * 2005-02-22 2006-08-31 Warner-Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds with keto or hydroxyl linkers for the treatment of schizophrenia
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
JP4315393B2 (ja) * 2005-04-14 2009-08-19 大塚製薬株式会社 複素環化合物
TWI329641B (en) 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
TW200831498A (en) * 2006-10-13 2008-08-01 Otsuka Pharma Co Ltd Heterocyclic compound
JP4540700B2 (ja) * 2006-10-13 2010-09-08 大塚製薬株式会社 医薬
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
EP2162135A4 (en) * 2007-05-21 2012-02-22 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS
US20090281322A1 (en) * 2008-05-08 2009-11-12 Allergan, Inc. THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS
BRPI0915052A2 (pt) 2008-05-08 2019-09-24 Allergan Inc compostos de 1,7-difenil-1,2,3,5,6,7-hexa-hidropirido [3,2,1-ij] quinolina substituído terapeuticamente úteis
KR101457339B1 (ko) * 2008-07-28 2014-11-03 지앙쑤 구오후아 인베스트먼트 컴퍼니 리미티드 아랄킬 치환된 피페리딘 또는 피페라진 유도체 및 정신분열증 치료를 위한 이의 용도
AU2009294695B2 (en) * 2008-09-22 2012-09-13 F. Hoffmann-La Roche Ag Piperazine D3 and 5-HT2a receptor modulators
JP2012502947A (ja) * 2008-09-23 2012-02-02 エフ.ホフマン−ラ ロシュ アーゲー ドーパミンD3受容体の調節剤として有用なベンゾ[d]イソオキサゾール−3−イル−ピペラジン誘導体
CA2766033C (en) 2009-06-25 2016-09-20 Alkermes, Inc. Prodrugs of nh-acidic compounds
CA2766088C (en) 2009-06-25 2017-06-13 Alkermes, Inc. Heterocyclic compounds for the treatment of neurological and psychological disorders
AU2014265021B2 (en) * 2009-06-25 2016-07-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
TWI503323B (zh) * 2010-03-29 2015-10-11 Oncotherapy Science Inc 三環化合物以及含此化合物之pbk抑制劑
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
EP4327872A2 (en) 2011-03-18 2024-02-28 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising sorbitan esters
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
CN103717587B (zh) 2011-07-28 2016-02-10 大塚制药株式会社 制造苯并[b]噻吩化合物的方法
JO3227B1 (ar) 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
ES2764383T3 (es) 2012-03-19 2020-06-03 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de glicerol
ES2765036T3 (es) 2012-03-19 2020-06-05 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden esteres de ácidos grasos
ES2950418T3 (es) 2012-03-19 2023-10-09 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden alcohol bencílico
WO2014080285A2 (en) 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
US9452131B2 (en) 2014-03-20 2016-09-27 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
JP5714152B2 (ja) * 2014-03-26 2015-05-07 江蘇恒誼薬業有限公司 アラルキルピペリジン(又はピペラジン)誘導体及びその統合失調症治療のための使用
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN106749219A (zh) * 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
JPWO2020230802A1 (ru) * 2019-05-14 2020-11-19
CN114728956B (zh) * 2019-11-18 2024-01-12 上海枢境生物科技有限公司 稠和杂环类衍生物及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
GB8723763D0 (en) * 1987-10-09 1987-11-11 Hydro Tech Ltd Liquid flow control device
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
JP2768981B2 (ja) * 1989-06-22 1998-06-25 シャープ株式会社 光メモリ素子
WO1991000863A1 (en) * 1989-07-07 1991-01-24 Pfizer Inc. Heteroaryl piperazine antipsychotic agents
US5350747A (en) * 1989-07-07 1994-09-27 Pfizer Inc Heteroaryl piperazine antipsychotic agents
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
IT1251144B (it) * 1991-07-30 1995-05-04 Boehringer Ingelheim Italia Derivati del benzimidazolone
TW300219B (ru) * 1991-09-14 1997-03-11 Hoechst Ag
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
UA57734C2 (ru) * 1996-05-07 2003-07-15 Пфайзер Інк. Комплексы включения арилгетероциклических солей
IL125951A (en) * 1997-09-05 2003-09-17 Pfizer Prod Inc A pharmaceutical composition comprising a piperazinyl-heterocyclic compound for treating tourette's syndrome, obsessive compulsive disorder, chronic motor or vocal tic disorder in a mammal
DE19746612A1 (de) * 1997-10-22 1999-04-29 Basf Ag 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
US6387904B2 (en) * 1998-05-18 2002-05-14 Pfizer Inc Method of treating glaucoma and ischemic retinopathy
SI1194425T1 (sl) * 1999-06-23 2005-12-31 Sanofi Aventis Deutschland Substituirani benzimidazoli

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