ATE377602T1 - Morphinanderivate und ihre medizinische anwendung - Google Patents

Morphinanderivate und ihre medizinische anwendung

Info

Publication number
ATE377602T1
ATE377602T1 AT98911044T AT98911044T ATE377602T1 AT E377602 T1 ATE377602 T1 AT E377602T1 AT 98911044 T AT98911044 T AT 98911044T AT 98911044 T AT98911044 T AT 98911044T AT E377602 T1 ATE377602 T1 AT E377602T1
Authority
AT
Austria
Prior art keywords
morphinan derivatives
medical applications
morphinan
derivatives
opioid
Prior art date
Application number
AT98911044T
Other languages
English (en)
Inventor
Hiroshi Nagase
Hideaki Fujii
Takashi Endoh
Koji Kawai
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE377602T1 publication Critical patent/ATE377602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98911044T 1997-03-27 1998-03-27 Morphinanderivate und ihre medizinische anwendung ATE377602T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7634097 1997-03-27

Publications (1)

Publication Number Publication Date
ATE377602T1 true ATE377602T1 (de) 2007-11-15

Family

ID=13602637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911044T ATE377602T1 (de) 1997-03-27 1998-03-27 Morphinanderivate und ihre medizinische anwendung

Country Status (12)

Country Link
US (1) US6187782B1 (de)
EP (1) EP0915094B1 (de)
KR (1) KR20000016052A (de)
CN (1) CN1150196C (de)
AT (1) ATE377602T1 (de)
AU (1) AU743929B2 (de)
CA (1) CA2256897C (de)
DE (1) DE69838662T2 (de)
ES (1) ES2297882T3 (de)
NO (1) NO985518L (de)
NZ (1) NZ333101A (de)
WO (1) WO1998043978A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
DK2073636T3 (da) * 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
EP2522667B1 (de) * 2007-05-01 2014-08-20 Concert Pharmaceuticals Inc. Morphinanverbindungen
PT2357183E (pt) 2007-05-01 2015-09-28 Concert Pharmaceuticals Inc Compostos de morfinano
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
WO2009149347A1 (en) 2008-06-05 2009-12-10 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
BRPI0920599B1 (pt) * 2008-10-24 2021-10-19 Toray Industries, Inc. Comprimido estável contendo um derivado de 4,5-epoximorfinano
WO2010059943A2 (en) 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds
CA2749315A1 (en) * 2009-01-09 2010-07-15 Tobias Ritter Fluorine containing compounds and methods of use thereof
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
CN103596931B (zh) 2011-04-12 2016-10-12 哈佛大学校长及研究员协会 有机化合物的氟化
ES2626983T3 (es) 2011-09-09 2017-07-26 The Kitasato Institute Derivado de morfinano
WO2014021273A1 (ja) * 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
ES2748803T3 (es) 2012-12-31 2020-03-18 Rhodes Tech Procedimiento para preparar 6,14-etenomorfinanos sustituidos en 7, 6,14-etanomorfinanos sustituidos en 7
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US10759764B2 (en) 2013-10-18 2020-09-01 President And Fellows Of Harvard College Fluorination of organic compounds
JP6814470B2 (ja) * 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
WO2019045006A1 (ja) * 2017-08-31 2019-03-07 日本ケミファ株式会社 モルヒナン誘導体
WO2019168025A1 (ja) * 2018-02-28 2019-09-06 日本ケミファ株式会社 モルヒナン誘導体の製造方法
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2229770A1 (de) * 1972-06-19 1974-01-10 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
JPS6163658A (ja) * 1984-07-05 1986-04-01 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー ３−ヒドロキシモルフイナン類の置換ベンゾエ−トエステルプロドラツグ誘導体
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.

Also Published As

Publication number Publication date
CN1220667A (zh) 1999-06-23
NO985518L (no) 1999-01-21
NZ333101A (en) 2000-05-26
AU743929B2 (en) 2002-02-07
ES2297882T3 (es) 2008-05-01
WO1998043978A1 (en) 1998-10-08
AU6518998A (en) 1998-10-22
EP0915094A4 (de) 2004-09-22
US6187782B1 (en) 2001-02-13
CA2256897C (en) 2006-10-03
NO985518D0 (no) 1998-11-26
EP0915094A1 (de) 1999-05-12
DE69838662T2 (de) 2008-08-28
CA2256897A1 (en) 1998-10-08
EP0915094B1 (de) 2007-11-07
DE69838662D1 (de) 2007-12-20
KR20000016052A (ko) 2000-03-25
CN1150196C (zh) 2004-05-19

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Legal Events

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