DE60039444D1 - Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes - Google Patents

Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes

Info

Publication number
DE60039444D1
DE60039444D1 DE60039444T DE60039444T DE60039444D1 DE 60039444 D1 DE60039444 D1 DE 60039444D1 DE 60039444 T DE60039444 T DE 60039444T DE 60039444 T DE60039444 T DE 60039444T DE 60039444 D1 DE60039444 D1 DE 60039444D1
Authority
DE
Germany
Prior art keywords
neuropathic pain
remedies
experimental models
neuropathic
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039444T
Other languages
English (en)
Inventor
Hiroshi Nagase
Takashi Endo
Kuniaki Kawamura
Toshiaki Tanaka
Tomohiko Suzuki
Tsutomu Suzuki
Yasushi Kuraishi
Kimiyasu Shiraki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE60039444D1 publication Critical patent/DE60039444D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60039444T 1999-08-24 2000-08-24 Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes Expired - Lifetime DE60039444D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23677899 1999-08-24
PCT/JP2000/005690 WO2001014383A1 (fr) 1999-08-24 2000-08-24 Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques

Publications (1)

Publication Number Publication Date
DE60039444D1 true DE60039444D1 (de) 2008-08-21

Family

ID=17005666

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039444T Expired - Lifetime DE60039444D1 (de) 1999-08-24 2000-08-24 Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes

Country Status (8)

Country Link
US (1) US8637539B2 (de)
EP (1) EP1219624B1 (de)
JP (1) JP4867123B2 (de)
CN (1) CN1204139C (de)
CA (1) CA2383146C (de)
DE (1) DE60039444D1 (de)
ES (1) ES2308990T3 (de)
WO (1) WO2001014383A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60143671D1 (de) * 2001-06-07 2011-01-27 Sang Christine Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
JP4957489B2 (ja) * 2002-10-09 2012-06-20 東レ株式会社 含窒素環状置換基を有するモルヒナン誘導体またはその薬理学的に許容される酸付加塩を含有する医薬
EP1611902A4 (de) * 2003-04-03 2006-04-12 Kyowa Hakko Kogyo Kk Mittel zur prävention und/oder behandlung von neuropathischen schmerzen
WO2006095836A1 (ja) * 2005-03-10 2006-09-14 Toray Industries, Inc. 多発性硬化症に伴う痒みに対する止痒剤
WO2008133297A1 (ja) 2007-04-24 2008-11-06 Toray Industries, Inc. ジスキネジアの治療または予防剤
CA2691220C (en) 2007-06-22 2015-05-05 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
AU2008308005B2 (en) 2007-10-05 2012-06-07 Toray Industries, Inc. Remedy for relieving skin troubles comprising morphinan derivative or pharmacologically acceptable acid addition salt thereof as the active ingredient
US10131672B2 (en) 2010-01-29 2018-11-20 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary diseases
AU2011317183B2 (en) * 2010-10-19 2016-10-20 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
WO2014136305A1 (ja) * 2013-03-08 2014-09-12 学校法人北里研究所 モルヒナン誘導体
WO2016176657A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CA3091752A1 (en) 2018-03-08 2019-09-12 Victoria Link Ltd Treatment of demyelinating diseases
CN109662802A (zh) * 2018-12-26 2019-04-23 南京大学 一种检测疼痛评价过程中运动协调性能的方法以及应用
US11214577B2 (en) 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders
CA3220039A1 (en) 2021-06-14 2022-12-22 Jr. David St. Jean Urea derivatives which can be used to treat cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
US5852030A (en) * 1992-09-29 1998-12-22 Toray Industries, Inc. Indole derivatives, process for producing the same and medicinal uses of the same
JP3605825B2 (ja) * 1992-09-29 2004-12-22 東レ株式会社 インドール誘導体，その製造方法およびその医薬用途
AU683664B2 (en) * 1993-06-30 1997-11-20 Toray Industries, Inc. Antitussive
EP0661283B1 (de) * 1993-07-19 1998-10-21 Toray Industries, Inc. Wirkstoff zum schutze von gehirnzellen
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
JP3858273B2 (ja) * 1995-07-20 2006-12-13 東レ株式会社 「４ａ−アリールデカヒドロイソキノリン化合物およびその医薬用途」
ES2197953T3 (es) * 1995-09-26 2004-01-16 Toray Industries, Inc. Derivados de indol y aplicaciones medicas de los mismos.
US6440987B1 (en) * 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
EP1312361A1 (de) * 1996-11-25 2003-05-21 Toray Industries, Inc. Mittel gegen Juckreiz
CN1117754C (zh) * 1997-01-16 2003-08-13 东丽株式会社 吲哚并吗啡喃衍生物及其组合物
ATE377602T1 (de) * 1997-03-27 2007-11-15 Toray Industries Morphinanderivate und ihre medizinische anwendung
CA2256336C (en) * 1997-03-31 2008-01-29 Toray Industries, Inc. Quinolinomorphinan derivative and medical use thereof
WO2001014382A1 (fr) 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif

Also Published As

Publication number Publication date
CN1204139C (zh) 2005-06-01
CA2383146C (en) 2010-11-16
JP4867123B2 (ja) 2012-02-01
ES2308990T3 (es) 2008-12-16
EP1219624A1 (de) 2002-07-03
CA2383146A1 (en) 2001-03-01
WO2001014383A1 (fr) 2001-03-01
US20060094741A1 (en) 2006-05-04
EP1219624B1 (de) 2008-07-09
US8637539B2 (en) 2014-01-28
EP1219624A4 (de) 2004-06-16
CN1382145A (zh) 2002-11-27

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Legal Events

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