ATE318266T1 - 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten - Google Patents
3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonistenInfo
- Publication number
- ATE318266T1 ATE318266T1 AT02761911T AT02761911T ATE318266T1 AT E318266 T1 ATE318266 T1 AT E318266T1 AT 02761911 T AT02761911 T AT 02761911T AT 02761911 T AT02761911 T AT 02761911T AT E318266 T1 ATE318266 T1 AT E318266T1
- Authority
- AT
- Austria
- Prior art keywords
- acid amide
- carbonic acid
- receptor antagonists
- amide derivatives
- substituted quinoline
- Prior art date
Links
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0109123.0A GB0109123D0 (en) | 2001-04-11 | 2001-04-11 | Novel compounds |
GB0205649A GB0205649D0 (en) | 2002-03-11 | 2002-03-11 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE318266T1 true ATE318266T1 (de) | 2006-03-15 |
Family
ID=26245967
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02735247T ATE313539T1 (de) | 2001-04-11 | 2002-04-11 | Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten |
AT02761911T ATE318266T1 (de) | 2001-04-11 | 2002-04-11 | 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02735247T ATE313539T1 (de) | 2001-04-11 | 2002-04-11 | Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten |
Country Status (7)
Country | Link |
---|---|
US (5) | US20040152726A1 (de) |
EP (3) | EP1377567B1 (de) |
JP (2) | JP2004525184A (de) |
AT (2) | ATE313539T1 (de) |
DE (2) | DE60209362T2 (de) |
ES (2) | ES2259096T3 (de) |
WO (2) | WO2002083663A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20031292A1 (it) * | 2003-06-25 | 2004-12-26 | Nikem Research Srl | Derivati biciclici nk-2 antagonisti selettivi. |
WO2005000247A2 (en) * | 2003-06-25 | 2005-01-06 | Smithkline Beecham Corporation | 4-carboxamido quinoline derivatives for use as nk-2 and nk-3 |
EP1740584B9 (de) | 2004-04-28 | 2010-06-09 | Takeda Pharmaceutical Company Limited | Kondensierte chinolinderivate und deren anwendung |
GB0417702D0 (en) * | 2004-08-09 | 2004-09-08 | Merck Sharp & Dohme | New uses |
GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
WO2006130080A2 (en) * | 2005-06-03 | 2006-12-07 | Astrazeneca Ab | Quinoline derivatives as nk3 anatgonists |
KR20080031871A (ko) * | 2005-06-23 | 2008-04-11 | 아스트라제네카 아베 | Nk3 수용체 조절제로서의 퀴놀린 3-술포네이트 에스테르 |
GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
WO2007035156A1 (en) * | 2005-09-21 | 2007-03-29 | Astrazeneca Ab | N-oxo-heterocycle and n-oxo-alkyl quinoline-4-carboxamides as nk-3 receptor ligands |
JP2010522177A (ja) * | 2007-03-23 | 2010-07-01 | アムジエン・インコーポレーテツド | 複素環化合物およびその使用 |
WO2008153027A1 (ja) * | 2007-06-11 | 2008-12-18 | Takeda Pharmaceutical Company Limited | ピロロキノリン誘導体およびその用途 |
PE20091093A1 (es) | 2007-12-03 | 2009-08-25 | Takeda Pharmaceutical | Compuesto heterociclico que contiene nitrogeno y su uso |
WO2009128262A1 (ja) * | 2008-04-15 | 2009-10-22 | 武田薬品工業株式会社 | キノロン誘導体およびその用途 |
US8242134B2 (en) | 2008-09-15 | 2012-08-14 | H. Lundbeck A/S | Isoquinolinone derivatives as NK3 antagonists |
MY164998A (en) * | 2008-09-15 | 2018-02-28 | Sojournix Inc | Isoquinolinone derivatives as nk3 antagonists |
USRE49686E1 (en) | 2008-09-19 | 2023-10-10 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
CN102584852B (zh) * | 2011-12-30 | 2014-08-13 | 厦门大学 | 真菌代谢产物桥南霉素及其制备方法和应用 |
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ES2227769T3 (es) * | 1994-05-27 | 2005-04-01 | Glaxosmithkline S.P.A. | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
AP9801237A0 (en) * | 1995-11-24 | 1998-06-30 | Smithkline Beecham Farm S P A | Quinoline derivatives. |
ATE244711T1 (de) * | 1997-05-23 | 2003-07-15 | Glaxosmithkline Spa | Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten |
GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
NZ511777A (en) * | 1998-11-20 | 2003-12-19 | Smithkline Beecham S | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
-
2002
- 2002-04-11 AT AT02735247T patent/ATE313539T1/de not_active IP Right Cessation
- 2002-04-11 EP EP02735247A patent/EP1377567B1/de not_active Expired - Lifetime
- 2002-04-11 EP EP02761911A patent/EP1385839B1/de not_active Expired - Lifetime
- 2002-04-11 ES ES02761911T patent/ES2259096T3/es not_active Expired - Lifetime
- 2002-04-11 DE DE60209362T patent/DE60209362T2/de not_active Expired - Fee Related
- 2002-04-11 AT AT02761911T patent/ATE318266T1/de not_active IP Right Cessation
- 2002-04-11 ES ES02735247T patent/ES2254688T3/es not_active Expired - Lifetime
- 2002-04-11 WO PCT/EP2002/004066 patent/WO2002083663A1/en active IP Right Grant
- 2002-04-11 JP JP2002581419A patent/JP2004525184A/ja active Pending
- 2002-04-11 JP JP2002581418A patent/JP2004525183A/ja active Pending
- 2002-04-11 DE DE60208178T patent/DE60208178T2/de not_active Expired - Fee Related
- 2002-04-11 US US10/474,542 patent/US20040152726A1/en not_active Abandoned
- 2002-04-11 WO PCT/EP2002/004070 patent/WO2002083664A1/en active IP Right Grant
- 2002-04-11 EP EP06075240A patent/EP1659120A1/de not_active Withdrawn
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2005
- 2005-04-06 US US11/100,256 patent/US20050176762A1/en not_active Abandoned
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2006
- 2006-06-28 US US11/426,956 patent/US20060229315A1/en not_active Abandoned
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2007
- 2007-03-13 US US11/685,380 patent/US20070161647A1/en not_active Abandoned
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DE60208178T2 (de) | 2006-08-24 |
US20070259882A1 (en) | 2007-11-08 |
EP1385839B1 (de) | 2006-02-22 |
US20040152726A1 (en) | 2004-08-05 |
EP1377567A1 (de) | 2004-01-07 |
EP1659120A1 (de) | 2006-05-24 |
DE60209362D1 (de) | 2006-04-27 |
ES2259096T3 (es) | 2006-09-16 |
EP1385839A1 (de) | 2004-02-04 |
DE60208178D1 (de) | 2006-01-26 |
EP1377567B1 (de) | 2005-12-21 |
ATE313539T1 (de) | 2006-01-15 |
US20050176762A1 (en) | 2005-08-11 |
JP2004525184A (ja) | 2004-08-19 |
DE60209362T2 (de) | 2006-10-26 |
WO2002083664A1 (en) | 2002-10-24 |
US20070161647A1 (en) | 2007-07-12 |
JP2004525183A (ja) | 2004-08-19 |
US20060229315A1 (en) | 2006-10-12 |
WO2002083663A1 (en) | 2002-10-24 |
ES2254688T3 (es) | 2006-06-16 |
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