DE60209362D1 - 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten - Google Patents

3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten

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Publication number
DE60209362D1
DE60209362D1 DE60209362T DE60209362T DE60209362D1 DE 60209362 D1 DE60209362 D1 DE 60209362D1 DE 60209362 T DE60209362 T DE 60209362T DE 60209362 T DE60209362 T DE 60209362T DE 60209362 D1 DE60209362 D1 DE 60209362D1
Authority
DE
Germany
Prior art keywords
chinolin
substituted
carboxylic acid
receptor antagonists
acid amid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60209362T
Other languages
English (en)
Other versions
DE60209362T2 (de
Inventor
Carlo Farina
Stefania Gagliardi
Arnaldo Giardina
Marisa Martinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0109123.0A external-priority patent/GB0109123D0/en
Priority claimed from GB0205649A external-priority patent/GB0205649D0/en
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Publication of DE60209362D1 publication Critical patent/DE60209362D1/de
Application granted granted Critical
Publication of DE60209362T2 publication Critical patent/DE60209362T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/04—Ortho-condensed systems
DE60209362T 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten Expired - Fee Related DE60209362T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0109123 2001-04-11
GBGB0109123.0A GB0109123D0 (en) 2001-04-11 2001-04-11 Novel compounds
GB0205649 2002-03-11
GB0205649A GB0205649D0 (en) 2002-03-11 2002-03-11 Novel compounds
PCT/EP2002/004070 WO2002083664A1 (en) 2001-04-11 2002-04-11 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Publications (2)

Publication Number Publication Date
DE60209362D1 true DE60209362D1 (de) 2006-04-27
DE60209362T2 DE60209362T2 (de) 2006-10-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
DE60208178T Expired - Fee Related DE60208178T2 (de) 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten
DE60209362T Expired - Fee Related DE60209362T2 (de) 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60208178T Expired - Fee Related DE60208178T2 (de) 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten

Country Status (7)

Country Link
US (5) US20040152726A1 (de)
EP (3) EP1659120A1 (de)
JP (2) JP2004525183A (de)
AT (2) ATE313539T1 (de)
DE (2) DE60208178T2 (de)
ES (2) ES2259096T3 (de)
WO (2) WO2002083663A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031292A1 (it) * 2003-06-25 2004-12-26 Nikem Research Srl Derivati biciclici nk-2 antagonisti selettivi.
WO2005000247A2 (en) * 2003-06-25 2005-01-06 Smithkline Beecham Corporation 4-carboxamido quinoline derivatives for use as nk-2 and nk-3
EP1740584B9 (de) 2004-04-28 2010-06-09 Takeda Pharmaceutical Company Limited Kondensierte chinolinderivate und deren anwendung
GB0417702D0 (en) * 2004-08-09 2004-09-08 Merck Sharp & Dohme New uses
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Ｎｋ3 길항제로서의 퀴놀린 유도체
US20080194622A1 (en) * 2005-06-23 2008-08-14 Astrazeneca Ab Quinoline 3-Sulfonate Esters as Nk3 Receptor Modulators
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
WO2007035156A1 (en) * 2005-09-21 2007-03-29 Astrazeneca Ab N-oxo-heterocycle and n-oxo-alkyl quinoline-4-carboxamides as nk-3 receptor ligands
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
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EP1659120A1 (de) 2006-05-24
EP1377567B1 (de) 2005-12-21
US20050176762A1 (en) 2005-08-11
US20070259882A1 (en) 2007-11-08
US20070161647A1 (en) 2007-07-12
DE60209362T2 (de) 2006-10-26
WO2002083664A1 (en) 2002-10-24
EP1385839B1 (de) 2006-02-22
DE60208178D1 (de) 2006-01-26
US20060229315A1 (en) 2006-10-12
EP1385839A1 (de) 2004-02-04
ES2259096T3 (es) 2006-09-16
DE60208178T2 (de) 2006-08-24
ATE318266T1 (de) 2006-03-15
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