EA200500803A1 - Антагонисты ccr1 для лечения воспалительных артритов, демиелинизационных воспалительных заболеваний - Google Patents

Антагонисты ccr1 для лечения воспалительных артритов, демиелинизационных воспалительных заболеваний

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Publication number
EA200500803A1
EA200500803A1 EA200500803A EA200500803A EA200500803A1 EA 200500803 A1 EA200500803 A1 EA 200500803A1 EA 200500803 A EA200500803 A EA 200500803A EA 200500803 A EA200500803 A EA 200500803A EA 200500803 A1 EA200500803 A1 EA 200500803A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
inflammatory
demielinization
compounds
ccr1 antagonists
Prior art date
Application number
EA200500803A
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English (en)
Other versions
EA007748B1 (ru
Inventor
Кеннет Дж. Карсон
Джеральдин Си. Би. Харриман
Original Assignee
Миллениум Фармасьютикалз, Инк.
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Application filed by Миллениум Фармасьютикалз, Инк. filed Critical Миллениум Фармасьютикалз, Инк.
Publication of EA200500803A1 publication Critical patent/EA200500803A1/ru
Publication of EA007748B1 publication Critical patent/EA007748B1/ru

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61P11/08—Bronchodilators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
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  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к соединениям, имеющим формулу (I)в которой Rпредставляет собой галоген. Изобретение также относится к композициям, содержащим эти соединения, и способам лечения заболеваний или нарушений, которые заключаются во введении одного или нескольких соединений субъекту, нуждающемуся в лечении. Описанные соединения обладают активностью CCR1 антагониста.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500803A 2002-11-13 2003-11-12 Антагонисты ccr1 для лечения воспалительных артритов, демиелинизационных воспалительных заболеваний EA007748B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42594702P 2002-11-13 2002-11-13
PCT/US2003/035817 WO2004043965A1 (en) 2002-11-13 2003-11-12 Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease

Publications (2)

Publication Number Publication Date
EA200500803A1 true EA200500803A1 (ru) 2005-10-27
EA007748B1 EA007748B1 (ru) 2006-12-29

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Family Applications (1)

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EA200500803A EA007748B1 (ru) 2002-11-13 2003-11-12 Антагонисты ccr1 для лечения воспалительных артритов, демиелинизационных воспалительных заболеваний

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US (7) US20040106639A1 (ru)
EP (2) EP1562954B1 (ru)
JP (1) JP4644491B2 (ru)
KR (1) KR101109348B1 (ru)
CN (1) CN100343257C (ru)
AR (1) AR041942A1 (ru)
AT (2) ATE468340T1 (ru)
AU (2) AU2003291452A1 (ru)
BR (1) BR0316261A (ru)
CA (1) CA2505874C (ru)
CY (1) CY1107985T1 (ru)
DE (2) DE60332663D1 (ru)
DK (1) DK1562954T3 (ru)
EA (1) EA007748B1 (ru)
ES (2) ES2346337T3 (ru)
HK (2) HK1086011A1 (ru)
IL (2) IL168384A (ru)
MX (1) MXPA05005105A (ru)
NO (1) NO331855B1 (ru)
PL (1) PL211022B1 (ru)
PT (1) PT1562954E (ru)
SI (1) SI1562954T1 (ru)
TW (1) TWI291467B (ru)
WO (1) WO2004043965A1 (ru)
ZA (2) ZA200504144B (ru)

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US20080139602A1 (en) 2008-06-12
ATE325124T1 (de) 2006-06-15
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