GB1206216A - Aminopropylidene dibenzoxepine tranquilizers - Google Patents

Aminopropylidene dibenzoxepine tranquilizers

Info

Publication number
GB1206216A
GB1206216A GB23194/68A GB2319468A GB1206216A GB 1206216 A GB1206216 A GB 1206216A GB 23194/68 A GB23194/68 A GB 23194/68A GB 2319468 A GB2319468 A GB 2319468A GB 1206216 A GB1206216 A GB 1206216A
Authority
GB
United Kingdom
Prior art keywords
oxepine
dihydrodibenz
piperazino
dibenzoxepine
aminopropylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23194/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB1206216A publication Critical patent/GB1206216A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,206,216. Aminopropylidene dibenzoxepine compounds. CHAS. PFIZER & CO. Inc. 15 May, 1968 [18 July, 1967], No. 23194/68. Heading C2C. Novel aminopropylidene dibenzoxepine compounds of the formula and the pharmaceutically-acceptable acid addition salts thereof, where Y is -S-, -SO-, or -SO 2 -; and Z is C 1-4 alkylamino, di- (C 1-4 alkyl) amino, pyrrolidino, piperidino, homopiperidino, morpholino, thiamorpholino, piperazino, N - (C 1-4 alkyl) piperazino or N- (C 2-4 hydroxyalkyl) piperazino, are obtained by treating the appropriate 2-CF 3 Y-substituted- 6,11 - dihydrodibenz - [b,e] - oxepine - 11 - one with a phosphorane compound of the formula R 3 P = CHCH 2 CH 2 Z, where R is C 1-6 alkyl, phenyl, aminophenyl or benzyl (the phosphorane compound being generated in situ by reaction of the corresponding phosphonium halide hydrohalide salt with a strong base such as nbutyl lithium), followed optionally by conversion to the acid addition salts. The preparation of the following intermediates is described: 2 - Trichloromethylthio - 6,11 - dihydrodibenz- [b,e] - oxepine - 11 - one is obtained by chlorinating the corresponding 2-methylthio compound, and is heated with antimony trifluoride to form 2 - trifluoromethylthio - 6,11 - dihydrobenz - [b,e] - oxepine - 11 - one. This product is also formed from p-trifluoromethylthiophenol by reacting with phthalide to yield 2-(p-trifluoromethylthiophenoxymethyl) - benzoic acid which is heated with P 2 O 5 to form the dihydrobenz-[b,e]-oxepinone; this product is reacted with m-chloroperbenzoic acid to form 2-trifluoromethylsulphinyl - 6,11 - dihydrodibenz- [b,e]-oxepine- 11 -cee.
GB23194/68A 1967-07-18 1968-05-15 Aminopropylidene dibenzoxepine tranquilizers Expired GB1206216A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65406967A 1967-07-18 1967-07-18

Publications (1)

Publication Number Publication Date
GB1206216A true GB1206216A (en) 1970-09-23

Family

ID=24623323

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23194/68A Expired GB1206216A (en) 1967-07-18 1968-05-15 Aminopropylidene dibenzoxepine tranquilizers

Country Status (2)

Country Link
FR (1) FR7617M (en)
GB (1) GB1206216A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7732459B2 (en) 2002-11-13 2010-06-08 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use therefor

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US8058287B2 (en) 2001-11-21 2011-11-15 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US8653096B2 (en) 2001-11-21 2014-02-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US9663537B2 (en) 2001-11-21 2017-05-30 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use
US7732459B2 (en) 2002-11-13 2010-06-08 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use therefor
US7977350B2 (en) 2002-11-13 2011-07-12 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use therefor
US8394817B2 (en) 2002-11-13 2013-03-12 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use therefor
US9334283B2 (en) 2002-11-13 2016-05-10 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use thereof

Also Published As

Publication number Publication date
FR7617M (en) 1970-01-19

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees