AU5812498A - Substituted aminoquinolines as modulators of chemokine receptor activity - Google Patents

Substituted aminoquinolines as modulators of chemokine receptor activity

Info

Publication number
AU5812498A
AU5812498A AU58124/98A AU5812498A AU5812498A AU 5812498 A AU5812498 A AU 5812498A AU 58124/98 A AU58124/98 A AU 58124/98A AU 5812498 A AU5812498 A AU 5812498A AU 5812498 A AU5812498 A AU 5812498A
Authority
AU
Australia
Prior art keywords
modulators
chemokine receptor
receptor activity
aminoquinolines
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU58124/98A
Inventor
William K. Hagmann
Martin S. Springer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9704345.9A external-priority patent/GB9704345D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU5812498A publication Critical patent/AU5812498A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU58124/98A 1996-12-20 1997-12-18 Substituted aminoquinolines as modulators of chemokine receptor activity Abandoned AU5812498A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3353696P 1996-12-20 1996-12-20
US60033536 1996-12-20
GB9704345 1997-03-03
GBGB9704345.9A GB9704345D0 (en) 1997-03-03 1997-03-03 Substituted aminoquinolines as modulators of chemokine receptor activity
PCT/US1997/024255 WO1998027815A1 (en) 1996-12-20 1997-12-18 Substituted aminoquinolines as modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
AU5812498A true AU5812498A (en) 1998-07-17

Family

ID=26311104

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58124/98A Abandoned AU5812498A (en) 1996-12-20 1997-12-18 Substituted aminoquinolines as modulators of chemokine receptor activity

Country Status (2)

Country Link
AU (1) AU5812498A (en)
WO (1) WO1998027815A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE69834814D1 (en) 1997-08-14 2006-07-20 Us Gov Health & Human Serv DELAYED PROGRESS OF AIDS THROUGH MISSENSE ALLELES OF THE CCR2 GENE
PL192083B1 (en) 1997-11-18 2006-08-31 Dupont Pharmaceuticals Res Lab Derivatives of cyclic amines and their application as drugs
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2319077A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EP1047675A1 (en) 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2347912A1 (en) 1998-12-18 2000-06-22 Soo S. Ko Heterocyclic piperidines as modulators of chemokine receptor activity
US6488930B1 (en) * 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
EP1152752A1 (en) * 1999-01-29 2001-11-14 Millennium Pharmaceuticals, Inc. Methods for preventing graft rejection and ischemia-reperfusion injury
ES2223481T3 (en) * 1999-03-10 2005-03-01 Smithkline Beecham Corporation BENZO (1,2-B: 5,4-B ') DIPIRAN-4-AMINAS REPLACED AS MODULATORS OF CCR5.
EP1050307A1 (en) * 1999-05-06 2000-11-08 Applied Research Systems ARS Holding N.V. CCR4 antagonists in sepsis
DK1179341T3 (en) 1999-05-18 2006-03-27 Teijin Ltd Medicines or preventive agents for diseases associated with chemokines
KR100667645B1 (en) 1999-08-04 2007-02-28 데이진 가부시키가이샤 Cyclic amine ccr3 antagonists
US6410566B1 (en) 2000-05-16 2002-06-25 Teijin Limited Cyclic amine derivatives and their use as drugs
US6962926B2 (en) 2001-01-31 2005-11-08 Telik, Inc. Antagonist of MCP-1 function, and compositions and methods of use thereof
US6670364B2 (en) 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
TWI245761B (en) 2001-03-01 2005-12-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
TWI236474B (en) 2001-04-03 2005-07-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2468015A1 (en) 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
WO2003045920A1 (en) * 2001-11-27 2003-06-05 Merck & Co., Inc. 4-aminoquinoline compounds
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7235558B2 (en) 2002-06-06 2007-06-26 Sanofi-Aventis Deutschland Gmbh Inhibitors of the GPIb—vWF interaction, their preparation and use
EP1369420A1 (en) * 2002-06-06 2003-12-10 Aventis Pharma Deutschland GmbH Inhibitors of the GPib - vWF interaction
RU2005102004A (en) 2002-06-27 2005-10-20 Шеринг Акциенгезельшафт (De) SUBSTITUTED QUINOLINS AS CCR5 RECEPTOR ANTAGONISTS
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2005105841A2 (en) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
EP3551046B1 (en) 2016-12-07 2023-07-19 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
KR20210095165A (en) 2018-11-19 2021-07-30 프로제너티, 인크. Methods and devices for treating diseases with biopharmaceuticals
CN115666704A (en) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 Ingestible device for delivery of therapeutic agents to the gastrointestinal tract
CN118021806A (en) 2020-02-19 2024-05-14 伊契洛夫科技有限公司 Improved antidepressant therapy
WO2024162814A1 (en) * 2023-02-01 2024-08-08 프라비바이오 주식회사 Novel bicyclic compound and use thereof

Also Published As

Publication number Publication date
WO1998027815A1 (en) 1998-07-02

Similar Documents

Publication Publication Date Title
AU5812498A (en) Substituted aminoquinolines as modulators of chemokine receptor activity
AU2482100A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU5522498A (en) Substituted aryl piperazines as modulators of chemokine receptor activity
AU2057200A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2056700A (en) 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
AU5803398A (en) Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5604998A (en) Spiro-substituted azacycles as modulators of chemokine receptor activity
AU2056800A (en) Heterocyclic piperidines as modulators of chemokine receptor activity
AU4074200A (en) Pyrrolidine modulators of chemokine receptor activity
AU4201200A (en) Pyrrolidine modulators of chemokine receptor activity
EP1003743A4 (en) 3,3-disubstituted piperidines as modulators of chemokine receptor activity
AU3659897A (en) Chemokine receptor antagonists and methods of use therefor
AU4483396A (en) Amylase variants
AU5600100A (en) Cyclopentyl modulators of chemokine receptor activity
AU3386400A (en) 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
AU3389300A (en) Pyrrolidine modulators of chemokine receptor activity
AU1616499A (en) Chemokine variants and methods of use
AU1201401A (en) Benzylcycloalkyl amines as modulators of chemokine receptor activity
AU3963397A (en) Preparation of y zeolite
HUP9702242A3 (en) Inozitol-glykanes of inzulin-like activity
AU2909597A (en) Use of hollow microcapsules
AU5473800A (en) Cyclopentyl modulators of chemokine receptor activity
AU4251197A (en) Therapeutic chemokine antagonists
AU6447998A (en) Human chemokine receptor-like chemokine