ATE432930T1 - Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen - Google Patents
Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzenInfo
- Publication number
- ATE432930T1 ATE432930T1 AT04742333T AT04742333T ATE432930T1 AT E432930 T1 ATE432930 T1 AT E432930T1 AT 04742333 T AT04742333 T AT 04742333T AT 04742333 T AT04742333 T AT 04742333T AT E432930 T1 ATE432930 T1 AT E432930T1
- Authority
- AT
- Austria
- Prior art keywords
- pain
- treatment
- production
- benzenesulphonamide
- compounds
- Prior art date
Links
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000004454 Hyperalgesia Diseases 0.000 abstract 1
- 208000035154 Hyperesthesia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0303602A FR2852958B1 (fr) | 2003-03-25 | 2003-03-25 | Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique |
| FR0304530A FR2853648B1 (fr) | 2003-04-11 | 2003-04-11 | Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique |
| PCT/FR2004/000723 WO2004087700A1 (fr) | 2003-03-25 | 2004-03-24 | Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432930T1 true ATE432930T1 (de) | 2009-06-15 |
Family
ID=33133107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04742333T ATE432930T1 (de) | 2003-03-25 | 2004-03-24 | Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7538111B2 (de) |
| EP (1) | EP1606288B1 (de) |
| JP (1) | JP4593559B2 (de) |
| AT (1) | ATE432930T1 (de) |
| AU (1) | AU2004226197B2 (de) |
| BR (1) | BRPI0408689B8 (de) |
| CA (1) | CA2519110C (de) |
| DE (1) | DE602004021358D1 (de) |
| DK (1) | DK1606288T3 (de) |
| EA (1) | EA008921B1 (de) |
| ES (1) | ES2327338T3 (de) |
| IL (1) | IL170630A (de) |
| MA (1) | MA27629A1 (de) |
| MX (1) | MXPA05010288A (de) |
| NO (1) | NO330888B1 (de) |
| PT (1) | PT1606288E (de) |
| SI (1) | SI1606288T1 (de) |
| TN (1) | TNSN05238A1 (de) |
| UA (1) | UA83821C2 (de) |
| WO (1) | WO2004087700A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
| DE102006039003A1 (de) * | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
| CA2666406A1 (en) * | 2006-10-16 | 2008-04-24 | Gruenenthal Gmbh | Substituted sulfonamide derivatives for use as bradykinin 1 receptor modulators |
| DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| EP2025675A1 (de) * | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer Wirkung |
| NZ583815A (en) * | 2007-08-14 | 2012-03-30 | Boehringer Ingelheim Int | Aryl Sulfonamides with an Analgesic Action |
| EP2229395A1 (de) * | 2008-01-17 | 2010-09-22 | Grünenthal GmbH | Substituierte sulfonamid-derivate |
| TW200940523A (en) * | 2008-03-17 | 2009-10-01 | Gruenenthal Gmbh | Substituted sulfonamide derivatives |
| MX2010011095A (es) | 2008-04-08 | 2010-11-05 | Gruenenthal Gmbh | Derivados de sulfonamidas sustituidos. |
| CL2009000852A1 (es) | 2008-04-08 | 2009-07-17 | Gruenenthal Gmbh | Compuestos derivados de sulfonamidas sustituidas; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto para el tratamiento del dolor agudo, cronico, inflamatorio, entre otros. |
| TWI482629B (zh) * | 2008-07-01 | 2015-05-01 | Tobishi Pharmaceutical Co | 下泌尿道疾病治療劑及下泌尿道症狀改善劑 |
| US8207335B2 (en) * | 2009-02-13 | 2012-06-26 | Boehringer Ingelheim International Gmbh | Process for making certain compounds having B1 antagonistic activity |
| WO2023028056A1 (en) | 2021-08-24 | 2023-03-02 | Genentech, Inc. | 3-amino piperidyl sodium channel inhibitors |
| JP2025538076A (ja) | 2022-11-03 | 2025-11-26 | オリック ファーマシューティカルズ， インコーポレイテッド | Ｅｇｆｒ阻害剤のマロン酸塩及びグリコール酸塩 |
| JP2025540560A (ja) * | 2022-11-03 | 2025-12-16 | ボロノイ インコーポレイテッド | Ｅｇｆｒ阻害剤のフマル酸塩、酒石酸塩、リンゴ酸塩、及びクエン酸塩 |
| MX2025012495A (es) | 2023-05-05 | 2026-02-03 | Oric Pharmaceuticals Inc | Inhibidor del receptor del factor de crecimiento epidérmico (egfr) para tratamiento de cánceres con mutaciones atípicas del factor de crecimiento epidérmico |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
| PT84171B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem |
| AU1354292A (en) | 1991-03-18 | 1992-10-21 | Pentapharm Ag | Parasubstituted phenylalanine derivates |
| DE4206858A1 (de) | 1992-03-05 | 1993-09-09 | Behringwerke Ag | Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| FR2701480B1 (fr) * | 1993-02-15 | 1995-05-24 | Sanofi Elf | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| FR2735128B1 (fr) | 1995-06-07 | 1997-07-25 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique. |
| US5834431A (en) | 1995-09-08 | 1998-11-10 | Cortech, Inc. | Des-Arg9 -BK antagonists |
| FR2743073B1 (fr) | 1995-12-29 | 1998-02-20 | Fournier Ind & Sante | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
| FR2743562B1 (fr) * | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
| FR2751650B1 (fr) | 1996-07-24 | 1998-10-09 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| US6153609A (en) * | 1996-08-23 | 2000-11-28 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| GB9621814D0 (en) * | 1996-10-19 | 1996-12-11 | British Biotech Pharm | Metalloproteinase inhibitors |
| FR2756562B1 (fr) | 1996-12-04 | 1999-01-08 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| FR2766148B1 (fr) | 1997-07-16 | 1999-09-17 | Soc D Const De Materiel Metall | Chariot comportant un dispositif de refroidissement pouvant etre mis en oeuvre a l'instant choisi par l'utilisateur et procede pour apporter un mets rechauffe |
| DE60005355T2 (de) | 1999-07-15 | 2004-07-01 | Pharmacopeia, Inc. | Bradikinin b1 rezeptor antagonisten |
| SE9903930D0 (sv) * | 1999-10-29 | 1999-10-29 | Astra Pharma Inc | Novel compounds and a novel process for their preparation |
| FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
| AR033879A1 (es) * | 2001-05-07 | 2004-01-07 | Smithkline Beecham Corp | Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto |
| AU2002346048A1 (en) | 2001-06-07 | 2002-12-16 | Merck And Co., Inc. | Benzodiazepine bradykinin antagonists |
-
2004
- 2004-03-24 WO PCT/FR2004/000723 patent/WO2004087700A1/fr not_active Ceased
- 2004-03-24 EP EP04742333A patent/EP1606288B1/de not_active Expired - Lifetime
- 2004-03-24 AU AU2004226197A patent/AU2004226197B2/en not_active Expired
- 2004-03-24 ES ES04742333T patent/ES2327338T3/es not_active Expired - Lifetime
- 2004-03-24 EA EA200501310A patent/EA008921B1/ru unknown
- 2004-03-24 UA UAA200509011A patent/UA83821C2/ru unknown
- 2004-03-24 SI SI200431203T patent/SI1606288T1/sl unknown
- 2004-03-24 AT AT04742333T patent/ATE432930T1/de active
- 2004-03-24 PT PT04742333T patent/PT1606288E/pt unknown
- 2004-03-24 MX MXPA05010288A patent/MXPA05010288A/es active IP Right Grant
- 2004-03-24 JP JP2006505749A patent/JP4593559B2/ja not_active Expired - Lifetime
- 2004-03-24 DK DK04742333T patent/DK1606288T3/da active
- 2004-03-24 US US10/549,546 patent/US7538111B2/en not_active Expired - Lifetime
- 2004-03-24 CA CA2519110A patent/CA2519110C/fr not_active Expired - Lifetime
- 2004-03-24 BR BRPI0408689A patent/BRPI0408689B8/pt not_active IP Right Cessation
- 2004-03-24 DE DE602004021358T patent/DE602004021358D1/de not_active Expired - Lifetime
-
2005
- 2005-09-01 IL IL170630A patent/IL170630A/en active IP Right Grant
- 2005-09-06 MA MA28480A patent/MA27629A1/fr unknown
- 2005-09-20 NO NO20054361A patent/NO330888B1/no unknown
- 2005-09-23 TN TNP2005000238A patent/TNSN05238A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1606288B1 (de) | 2009-06-03 |
| US20060178360A1 (en) | 2006-08-10 |
| CA2519110C (fr) | 2012-09-18 |
| EP1606288A1 (de) | 2005-12-21 |
| EA200501310A1 (ru) | 2006-06-30 |
| SI1606288T1 (sl) | 2009-10-31 |
| AU2004226197B2 (en) | 2009-12-03 |
| PT1606288E (pt) | 2009-08-26 |
| UA83821C2 (ru) | 2008-08-26 |
| US7538111B2 (en) | 2009-05-26 |
| BRPI0408689B8 (pt) | 2021-05-25 |
| TNSN05238A1 (fr) | 2007-06-11 |
| JP2006521333A (ja) | 2006-09-21 |
| DE602004021358D1 (de) | 2009-07-16 |
| NO20054361D0 (no) | 2005-09-20 |
| MA27629A1 (fr) | 2005-11-01 |
| JP4593559B2 (ja) | 2010-12-08 |
| CA2519110A1 (fr) | 2004-10-14 |
| NO330888B1 (no) | 2011-08-08 |
| AU2004226197A1 (en) | 2004-10-14 |
| DK1606288T3 (da) | 2009-10-05 |
| EA008921B1 (ru) | 2007-08-31 |
| BRPI0408689B1 (pt) | 2018-09-11 |
| ES2327338T3 (es) | 2009-10-28 |
| WO2004087700A8 (fr) | 2004-11-18 |
| NO20054361L (no) | 2005-11-01 |
| WO2004087700A1 (fr) | 2004-10-14 |
| IL170630A (en) | 2012-02-29 |
| MXPA05010288A (es) | 2005-11-17 |
| BRPI0408689A (pt) | 2006-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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