EA200802400A1 - Полиморфные формы и способ - Google Patents

Полиморфные формы и способ

Info

Publication number
EA200802400A1
EA200802400A1 EA200802400A EA200802400A EA200802400A1 EA 200802400 A1 EA200802400 A1 EA 200802400A1 EA 200802400 A EA200802400 A EA 200802400A EA 200802400 A EA200802400 A EA 200802400A EA 200802400 A1 EA200802400 A1 EA 200802400A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymorphic forms
paragraph
cancer
applicable
formula
Prior art date
Application number
EA200802400A
Other languages
English (en)
Other versions
EA015994B1 (ru
Inventor
Кай Шиманн
Ульрих Эмде
Тобиас Шлютер
Кристоф Заал
Михаэль Майвальд
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA200802400A1 publication Critical patent/EA200802400A1/ru
Publication of EA015994B1 publication Critical patent/EA015994B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к способу получения энантиомерно обогащенных или чистых соединений формулы 1где R, R, R, R, Rи Q имеют значения, указанные в пункте 1, а также их кристаллических форм, применимых для лечения пролиферативных заболеваний, таких как рак.
EA200802400A 2006-06-19 2007-05-26 Способ получения энантиомерно обогащенных или чистых соединений EA015994B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06012525 2006-06-19
PCT/EP2007/004711 WO2007147480A2 (en) 2006-06-19 2007-05-26 Polymorphic forms and process

Publications (2)

Publication Number Publication Date
EA200802400A1 true EA200802400A1 (ru) 2009-06-30
EA015994B1 EA015994B1 (ru) 2012-01-30

Family

ID=38687475

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802400A EA015994B1 (ru) 2006-06-19 2007-05-26 Способ получения энантиомерно обогащенных или чистых соединений

Country Status (19)

Country Link
US (1) US8198452B2 (ru)
EP (1) EP2032581B1 (ru)
JP (1) JP5322928B2 (ru)
KR (1) KR20090020702A (ru)
CN (1) CN101472928A (ru)
AR (1) AR061379A1 (ru)
AU (1) AU2007263393B2 (ru)
BR (1) BRPI0712393A2 (ru)
CA (1) CA2656064C (ru)
EA (1) EA015994B1 (ru)
EC (1) ECSP099077A (ru)
ES (1) ES2537759T3 (ru)
IL (1) IL195844A0 (ru)
MX (1) MX2008016071A (ru)
NZ (1) NZ574236A (ru)
PE (1) PE20080337A1 (ru)
TW (1) TW200815453A (ru)
WO (1) WO2007147480A2 (ru)
ZA (1) ZA200900383B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005027170A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Substituierte Tetrahydrochinoline
DE102007021862A1 (de) * 2007-05-10 2008-11-13 Merck Patent Gmbh Wässrige pharmazeutische Zubereitung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil
JPH07247286A (ja) * 1994-01-18 1995-09-26 Sankyo Co Ltd 含窒素環状化合物の光学分割方法
JPH07330732A (ja) * 1994-06-10 1995-12-19 Kyorin Pharmaceut Co Ltd 光学活性な３−アミノ−１−ベンジルピペリジン誘導体
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
ATE413393T1 (de) 2003-12-20 2008-11-15 Merck Patent Gmbh 2-(hetero-)aryl substituierte tetrahydrochinolinderivate

Also Published As

Publication number Publication date
EP2032581B1 (en) 2015-03-11
WO2007147480A2 (en) 2007-12-27
MX2008016071A (es) 2009-01-15
NZ574236A (en) 2010-11-26
EA015994B1 (ru) 2012-01-30
CN101472928A (zh) 2009-07-01
CA2656064C (en) 2013-11-05
JP5322928B2 (ja) 2013-10-23
BRPI0712393A2 (pt) 2012-10-16
TW200815453A (en) 2008-04-01
AR061379A1 (es) 2008-08-20
ZA200900383B (en) 2010-01-27
US8198452B2 (en) 2012-06-12
PE20080337A1 (es) 2008-04-25
JP2009541231A (ja) 2009-11-26
EP2032581A2 (en) 2009-03-11
KR20090020702A (ko) 2009-02-26
WO2007147480A3 (en) 2008-05-08
AU2007263393B2 (en) 2012-03-01
AU2007263393A1 (en) 2007-12-27
CA2656064A1 (en) 2007-12-27
IL195844A0 (en) 2009-09-01
US20090176820A1 (en) 2009-07-09
ECSP099077A (es) 2009-02-27
ES2537759T3 (es) 2015-06-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU