ATE543494T1 - Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung - Google Patents

Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung

Info

Publication number
ATE543494T1
ATE543494T1 AT08761406T AT08761406T ATE543494T1 AT E543494 T1 ATE543494 T1 AT E543494T1 AT 08761406 T AT08761406 T AT 08761406T AT 08761406 T AT08761406 T AT 08761406T AT E543494 T1 ATE543494 T1 AT E543494T1
Authority
AT
Austria
Prior art keywords
griseofulvin
analogs
inhibiting
treating cancer
cluster formation
Prior art date
Application number
AT08761406T
Other languages
English (en)
Inventor
Mads Clausen
Alwin Kraemer
Thomas Ostenfeld Larsen
Blanka Rebacz
Original Assignee
Dkfz Krebsforschungszentrum
Univ Denmark Tech Dtu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dkfz Krebsforschungszentrum, Univ Denmark Tech Dtu filed Critical Dkfz Krebsforschungszentrum
Application granted granted Critical
Publication of ATE543494T1 publication Critical patent/ATE543494T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT08761406T 2007-06-28 2008-06-30 Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung ATE543494T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07111335A EP2008652A1 (de) 2007-06-28 2007-06-28 Griseofulvinanaloge zur Behandlung von Krebs durch Hemmung von zentrosomalem Clustering
PCT/EP2008/058410 WO2009000937A1 (en) 2007-06-28 2008-06-30 Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

Publications (1)

Publication Number Publication Date
ATE543494T1 true ATE543494T1 (de) 2012-02-15

Family

ID=38667076

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08761406T ATE543494T1 (de) 2007-06-28 2008-06-30 Griseofulvin-analoga zur behandlung von krebs durch hemmung von zentrosomaler clusterbildung

Country Status (6)

Country Link
US (1) US20110178170A1 (de)
EP (2) EP2008652A1 (de)
AT (1) ATE543494T1 (de)
DK (1) DK2190426T3 (de)
ES (1) ES2381057T3 (de)
WO (1) WO2009000937A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2204367A1 (de) 2008-12-22 2010-07-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Griseofulvinanaloge zur Behandlung von Krebs durch Hemmung von zentrosomalem Clustering
EP2880024A1 (de) * 2012-08-01 2015-06-10 Pierre Fabre Médicament Griseofulvinderivate
CN103058971B (zh) * 2013-01-17 2014-08-06 福州大学 一种源于棘孢曲霉的苯醌螺环化合物及其应用
CN104860909B (zh) * 2015-04-09 2017-03-08 西北农林科技大学 灰黄霉素衍生物、灰黄霉素及其衍生物的抗菌活性应用
HUE058182T2 (hu) 2016-03-30 2022-07-28 Daiichi Sankyo Co Ltd Grizeofulvin vegyület
TWI811243B (zh) 2017-09-29 2023-08-11 日商第一三共股份有限公司 灰黃黴素化合物及醫藥用途
KR102125005B1 (ko) * 2017-10-27 2020-06-22 한양대학교 에리카산학협력단 53bp1의 신규한 용도
CN108484552B (zh) * 2018-06-15 2020-03-10 河南大学 一种多取代3-苯并呋喃酮螺环己烯衍生物及其制备方法
CN108823110B (zh) * 2018-07-26 2021-07-16 福州工微生物科技有限公司 一株产灰黄霉素的菌株及其应用
CN112080438B (zh) * 2020-10-15 2023-05-12 内蒙古格林特制药有限责任公司 一种灰黄霉素低产沫菌种及低产沫菌种的制备方法和应用
CN116076510B (zh) * 2022-05-30 2024-10-29 河南大学 多取代3-苯并呋喃酮螺环己烯衍生物作为杀菌剂在防治植物病菌中的应用
CN116199657B (zh) * 2023-02-20 2024-11-29 延安大学 灰黄霉素4位醚化衍生物及其应用
CN117229246B (zh) * 2023-05-23 2024-06-07 湖北天勤生物科技股份有限公司 具有抗炎活性的化合物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9609920A (pt) * 1995-08-03 1999-07-06 Procter & Gamble Uso de griseofulvina para inibir o crescimento de cânceres

Also Published As

Publication number Publication date
WO2009000937A1 (en) 2008-12-31
EP2190426B1 (de) 2012-02-01
EP2190426A1 (de) 2010-06-02
DK2190426T3 (da) 2012-03-26
EP2008652A1 (de) 2008-12-31
ES2381057T3 (es) 2012-05-22
US20110178170A1 (en) 2011-07-21

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