DK1853602T3 - Kemiske forbindelser - Google Patents
Kemiske forbindelserInfo
- Publication number
- DK1853602T3 DK1853602T3 DK06709759.2T DK06709759T DK1853602T3 DK 1853602 T3 DK1853602 T3 DK 1853602T3 DK 06709759 T DK06709759 T DK 06709759T DK 1853602 T3 DK1853602 T3 DK 1853602T3
- Authority
- DK
- Denmark
- Prior art keywords
- chemical compounds
- novel compounds
- cancer
- formula
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65333005P | 2005-02-16 | 2005-02-16 | |
| US73296505P | 2005-11-03 | 2005-11-03 | |
| PCT/GB2006/000522 WO2006087538A1 (en) | 2005-02-16 | 2006-02-15 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1853602T3 true DK1853602T3 (da) | 2010-09-20 |
Family
ID=36129856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06709759.2T DK1853602T3 (da) | 2005-02-16 | 2006-02-15 | Kemiske forbindelser |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7622482B2 (da) |
| EP (1) | EP1853602B1 (da) |
| JP (1) | JP2008530191A (da) |
| KR (1) | KR20070104936A (da) |
| AT (1) | ATE473975T1 (da) |
| AU (1) | AU2006215394B2 (da) |
| BR (1) | BRPI0608160A2 (da) |
| CA (1) | CA2598076A1 (da) |
| CY (1) | CY1110900T1 (da) |
| DE (1) | DE602006015431D1 (da) |
| DK (1) | DK1853602T3 (da) |
| ES (1) | ES2347172T3 (da) |
| HK (1) | HK1113352A1 (da) |
| HR (1) | HRP20100477T1 (da) |
| IL (1) | IL184872A0 (da) |
| MX (1) | MX2007009842A (da) |
| NO (1) | NO20073790L (da) |
| NZ (1) | NZ561526A (da) |
| PL (1) | PL1853602T3 (da) |
| PT (1) | PT1853602E (da) |
| SI (1) | SI1853602T1 (da) |
| WO (1) | WO2006087538A1 (da) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS52061B (en) | 2005-02-04 | 2012-04-30 | Astrazeneca Ab | PIRAZOLYL-AMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS |
| WO2006087530A1 (en) | 2005-02-16 | 2006-08-24 | Astrazeneca Ab | Chemical compounds |
| BRPI0618011A2 (pt) | 2005-10-28 | 2011-08-16 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para produzir um efeito anti-proliferativo e um efeito pró-apoptósico em um animal de sangue quente, para tratar doença e para produzir um efeito inibidor de jak em um animal de sangue quente |
| US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| AR063141A1 (es) | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | Derivados de 2- ( benzimidazolil ) purina 8- sustituida para inmunosupresion |
| AR063142A1 (es) | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | Derivados de 2-(bencimidazolil) purina y purinonas 6-sustituidas utiles como inmunosupresores,y composiciones farmaceuticas que los contienen. |
| NZ576278A (en) * | 2006-10-19 | 2011-12-22 | Signal Pharm Llc | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors |
| EP2155742A1 (en) * | 2007-04-18 | 2010-02-24 | AstraZeneca AB | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b]pyridine derivatives and their use for the treatment of cancer |
| EP2152708A1 (en) * | 2007-05-23 | 2010-02-17 | Pharmacopeia, LLC | Purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| WO2009071535A1 (en) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| PT2350075E (pt) * | 2008-09-22 | 2014-06-09 | Array Biopharma Inc | Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase |
| SG10201914059WA (en) * | 2008-10-22 | 2020-03-30 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| AU2015200511B2 (en) * | 2008-10-22 | 2017-08-31 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
| PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| WO2011079804A1 (en) * | 2009-12-31 | 2011-07-07 | Hutchison Medipharma Limited | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor |
| CN102947302A (zh) | 2010-02-18 | 2013-02-27 | 西班牙国家癌症研究中心 | 三唑并[4，5-b]吡啶衍生物 |
| WO2011134668A1 (en) | 2010-04-30 | 2011-11-03 | Telormedix Sa | Phospholipid drug analogs |
| US9050319B2 (en) | 2010-04-30 | 2015-06-09 | Telormedix, Sa | Phospholipid drug analogs |
| MX365251B (es) | 2010-05-20 | 2019-05-28 | Array Biopharma Inc | Compuestos macrocíclicos como inhibidores de trk cinasa. |
| WO2012097478A1 (en) * | 2011-01-21 | 2012-07-26 | Abbott Laboratories | Bicyclic carboxamide inhibitors of kinases |
| WO2013009582A1 (en) | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
| US9181261B2 (en) | 2012-05-22 | 2015-11-10 | Merck Sharp & Dohme Corp. | TrkA kinase inhibitors, compositions and methods thereof |
| TWI585088B (zh) | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
| US20160222014A1 (en) * | 2013-09-10 | 2016-08-04 | Asana Biosciences, Llc | Compounds for regulating fak and/or src pathways |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| WO2015039334A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| WO2015039333A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| WO2015143654A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| CN113354649A (zh) | 2014-11-16 | 2021-09-07 | 阵列生物制药公司 | 一种新的晶型 |
| MY191736A (en) | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| PE20181888A1 (es) | 2016-04-04 | 2018-12-11 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| KR20210010652A (ko) | 2016-04-04 | 2021-01-27 | 록쏘 온콜로지, 인코포레이티드 | 소아암을 치료하는 방법 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| RU2745953C2 (ru) | 2016-05-18 | 2021-04-05 | Локсо Онколоджи, Инк. | Способ получения (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)-пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида и его солей |
| EP3502111B1 (en) | 2016-08-22 | 2022-07-27 | Medshine Discovery Inc. | Pde4 inhibitor |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| AU2019335450A1 (en) | 2018-09-03 | 2021-05-06 | Tyligand Bioscience (Shanghai) Limited | TRK inhibitor as anti-cancer drug |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN113278022B (zh) * | 2020-07-07 | 2023-12-12 | 南京纳丁菲医药科技有限公司 | 吡唑并嘧啶化合物和药物组合物及其应用 |
| CN115141195B (zh) * | 2021-03-03 | 2024-02-06 | 成都先导药物开发股份有限公司 | 一种nuak抑制剂及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399780B1 (en) * | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
| BR0116411A (pt) * | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| PT1383731E (pt) * | 2001-04-06 | 2009-11-03 | Biocryst Pharm Inc | Compostos de biarilo como inibidores de serina-protease |
| ES2275021T3 (es) * | 2001-09-27 | 2007-06-01 | Smithkline Beecham Corporation | Derivados de azoxoindol como inhibidores de trk proteina quinasa para el tratamiento de cancer y dolor cronico. |
-
2006
- 2006-02-15 ES ES06709759T patent/ES2347172T3/es active Active
- 2006-02-15 CA CA002598076A patent/CA2598076A1/en not_active Abandoned
- 2006-02-15 BR BRPI0608160-6A patent/BRPI0608160A2/pt not_active IP Right Cessation
- 2006-02-15 PT PT06709759T patent/PT1853602E/pt unknown
- 2006-02-15 US US11/816,376 patent/US7622482B2/en not_active Expired - Fee Related
- 2006-02-15 DK DK06709759.2T patent/DK1853602T3/da active
- 2006-02-15 EP EP06709759A patent/EP1853602B1/en active Active
- 2006-02-15 KR KR1020077021200A patent/KR20070104936A/ko not_active Application Discontinuation
- 2006-02-15 AT AT06709759T patent/ATE473975T1/de active
- 2006-02-15 AU AU2006215394A patent/AU2006215394B2/en not_active Ceased
- 2006-02-15 JP JP2007555690A patent/JP2008530191A/ja active Pending
- 2006-02-15 DE DE602006015431T patent/DE602006015431D1/de active Active
- 2006-02-15 SI SI200630760T patent/SI1853602T1/sl unknown
- 2006-02-15 PL PL06709759T patent/PL1853602T3/pl unknown
- 2006-02-15 MX MX2007009842A patent/MX2007009842A/es not_active Application Discontinuation
- 2006-02-15 WO PCT/GB2006/000522 patent/WO2006087538A1/en active Application Filing
- 2006-02-15 NZ NZ561526A patent/NZ561526A/en not_active IP Right Cessation
-
2007
- 2007-07-20 NO NO20073790A patent/NO20073790L/no not_active Application Discontinuation
- 2007-07-26 IL IL184872A patent/IL184872A0/en unknown
-
2008
- 2008-03-07 HK HK08102714.3A patent/HK1113352A1/xx not_active IP Right Cessation
-
2010
- 2010-08-31 HR HR20100477T patent/HRP20100477T1/hr unknown
- 2010-09-09 CY CY20101100825T patent/CY1110900T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006215394A1 (en) | 2006-08-24 |
| HK1113352A1 (en) | 2008-10-03 |
| US7622482B2 (en) | 2009-11-24 |
| PL1853602T3 (pl) | 2010-11-30 |
| NO20073790L (no) | 2007-09-03 |
| IL184872A0 (en) | 2007-12-03 |
| CY1110900T1 (el) | 2015-06-10 |
| MX2007009842A (es) | 2007-08-23 |
| US20090137624A1 (en) | 2009-05-28 |
| EP1853602A1 (en) | 2007-11-14 |
| HRP20100477T1 (hr) | 2010-10-31 |
| NZ561526A (en) | 2010-11-26 |
| PT1853602E (pt) | 2010-08-25 |
| SI1853602T1 (sl) | 2010-11-30 |
| KR20070104936A (ko) | 2007-10-29 |
| ATE473975T1 (de) | 2010-07-15 |
| EP1853602B1 (en) | 2010-07-14 |
| ES2347172T3 (es) | 2010-10-26 |
| AU2006215394B2 (en) | 2009-10-08 |
| CA2598076A1 (en) | 2006-08-24 |
| WO2006087538A1 (en) | 2006-08-24 |
| JP2008530191A (ja) | 2008-08-07 |
| BRPI0608160A2 (pt) | 2010-11-09 |
| DE602006015431D1 (de) | 2010-08-26 |
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