PA8851101A1 - Compuesto amino pirazol - Google Patents

Compuesto amino pirazol

Info

Publication number
PA8851101A1
PA8851101A1 PA20098851101A PA8851101A PA8851101A1 PA 8851101 A1 PA8851101 A1 PA 8851101A1 PA 20098851101 A PA20098851101 A PA 20098851101A PA 8851101 A PA8851101 A PA 8851101A PA 8851101 A1 PA8851101 A1 PA 8851101A1
Authority
PA
Panama
Prior art keywords
pirazol
amino
compound
cancer
meloproliferant
Prior art date
Application number
PA20098851101A
Other languages
English (en)
Inventor
Paul Burkholder Timothy
Ryan Clayton Joshua
Ma Liandong
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41630090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8851101(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PA8851101A1 publication Critical patent/PA8851101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

LA PRESENTE INVENCIÓN PROVEE COMPUESTOS AMINO PIRAZOL ÚTILES EN EL TRATAMIENTO DE TRASTORNOS MIELOPROLIFERANTES CRÓNICOS Y VARIOS CÁNCERES,POR EJEMPLO,GLIOBLASTOMA,CÁNCER DE MAMA,MIELOMA MÚLTIPLE,CÁNCER DE PRÓSTATA,Y LEUCEMIAS.
PA20098851101A 2008-12-16 2009-11-30 Compuesto amino pirazol PA8851101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12285408P 2008-12-16 2008-12-16

Publications (1)

Publication Number Publication Date
PA8851101A1 true PA8851101A1 (es) 2010-07-27

Family

ID=41630090

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098851101A PA8851101A1 (es) 2008-12-16 2009-11-30 Compuesto amino pirazol

Country Status (39)

Country Link
US (2) US20100286139A1 (es)
EP (1) EP2379557B1 (es)
JP (1) JP5509217B2 (es)
KR (1) KR101300458B1 (es)
CN (1) CN102232075B (es)
AR (1) AR074240A1 (es)
AU (1) AU2009330503B2 (es)
BR (1) BRPI0923048A2 (es)
CA (1) CA2744714C (es)
CL (1) CL2011001445A1 (es)
CO (1) CO6331442A2 (es)
CR (1) CR20110341A (es)
CY (1) CY1113637T1 (es)
DK (1) DK2379557T3 (es)
DO (1) DOP2011000190A (es)
EA (1) EA019554B1 (es)
EC (1) ECSP11011132A (es)
ES (1) ES2396617T3 (es)
HK (1) HK1160109A1 (es)
HN (1) HN2011001697A (es)
HR (1) HRP20120918T1 (es)
IL (1) IL213065A0 (es)
JO (1) JO2833B1 (es)
MA (1) MA32900B1 (es)
MX (1) MX2011006441A (es)
MY (1) MY158691A (es)
NZ (1) NZ592641A (es)
PA (1) PA8851101A1 (es)
PE (1) PE20110549A1 (es)
PL (1) PL2379557T3 (es)
PT (1) PT2379557E (es)
SG (1) SG172202A1 (es)
SI (1) SI2379557T1 (es)
SV (1) SV2011003949A (es)
TN (1) TN2011000292A1 (es)
TW (1) TWI440640B (es)
UA (1) UA104743C2 (es)
WO (1) WO2010074947A1 (es)
ZA (1) ZA201103942B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2435646A (en) * 2006-03-01 2007-09-05 Spin Tec Engineering Gmbh Apparatus and method of extraction of an arthropod gland
US8105633B2 (en) * 2006-03-01 2012-01-31 Spintec Engineering Gmbh Method and apparatus for extraction of arthropod gland
US20110121485A1 (en) * 2006-10-30 2011-05-26 Spintec Engineering Gmbh Method and apparatus for the manufacture of a fiber
AU2012224584A1 (en) * 2011-03-07 2013-10-10 Fondazione Telethon TFEB phosphorylation inhibitors and uses thereof
JP6228113B2 (ja) * 2011-06-15 2017-11-08 ライフ・アンド・ブレイン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＬＩＦＥ ＡＮＤ ＢＲＡＩＮ ＧｍｂＨ グリア芽腫阻害化合物およびその使用
EP2872161B1 (en) 2012-06-26 2020-12-16 Del Mar Pharmaceuticals Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations
PL400213A1 (pl) 2012-08-01 2014-02-03 Celon Pharma Spólka Z Ograniczona Odpowiedzialnoscia Pochodne imidazo[1,2-b]pirydazyno-6-aminy jako inhibitory kinazy JAK-2
AR101504A1 (es) 2014-08-11 2016-12-21 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6
HRP20220738T1 (hr) 2014-08-11 2022-08-19 Acerta Pharma B.V. Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1
EP3179991B1 (en) 2014-08-11 2021-10-06 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
WO2018093968A1 (en) * 2016-11-17 2018-05-24 Bristol-Myers Squibb Company Imidazopyridazine modulators of il-12, il-23 and/or ifn-alpha
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
EP3610264A1 (en) 2017-04-13 2020-02-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN110305140B (zh) 2019-07-30 2020-08-04 上海勋和医药科技有限公司 二氢吡咯并嘧啶类选择性jak2抑制剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005606A (es) 2000-12-21 2003-10-06 Vertex Pharma Compuestos de pirazol utiles como inhibidores de la proteina cinasa.
JP2003137785A (ja) * 2001-08-23 2003-05-14 Takeda Chem Ind Ltd Ｊｎｋ活性化阻害剤
HUP0402458A2 (hu) 2001-12-21 2005-07-28 Anormed Inc. Fokozott hatékonyságú kemokin receptor kötő heterociklusos vegyületek
SI1853588T1 (sl) 2005-02-16 2008-10-31 Astrazeneca Ab Kemične spojine
BRPI0608160A2 (pt) 2005-02-16 2010-11-09 Astrazeneca Ab anticorpo isolado, célula hospedeira, método de inibir o crescimento de células psma+, e, uso de um anticorpo anti-psma defucosilado
AU2006265840B2 (en) * 2005-07-01 2010-02-11 Irm Llc Pyrimidine-substituted benzimidazole derivatives as protein kinase inhibitors
GB0515026D0 (en) 2005-07-21 2005-08-31 Novartis Ag Organic compounds
WO2007041712A1 (en) * 2005-10-06 2007-04-12 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
CN101321759A (zh) 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶化合物
EP1963329B1 (en) 2005-11-30 2013-01-23 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
EP2063962A2 (en) 2006-09-07 2009-06-03 Biogen Idec MA Inc. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
RU2009120389A (ru) * 2006-10-30 2010-12-10 Новартис АГ (CH) Гетероциклические соединения в качестве противовоспалительных агентов
CN101679429A (zh) * 2007-04-18 2010-03-24 阿斯利康(瑞典)有限公司 5-氨基吡唑-3-基-3h-咪唑并[4,5-b]吡啶衍生物及其治疗癌的用途
CN101679412A (zh) 2007-05-23 2010-03-24 药典有限责任公司 作为PKC-θ抑制剂的嘌呤酮类和1H-咪唑并吡啶酮类
WO2009062059A2 (en) 2007-11-08 2009-05-14 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors

Also Published As

Publication number Publication date
SI2379557T1 (sl) 2013-02-28
MA32900B1 (fr) 2011-12-01
SV2011003949A (es) 2011-07-21
UA104743C2 (ru) 2014-03-11
ECSP11011132A (es) 2011-07-29
US7897600B2 (en) 2011-03-01
NZ592641A (en) 2013-01-25
HK1160109A1 (en) 2012-08-10
CO6331442A2 (es) 2011-10-20
CA2744714A1 (en) 2010-07-01
EA201170831A1 (ru) 2011-12-30
TWI440640B (zh) 2014-06-11
TN2011000292A1 (en) 2012-12-17
US20100152181A1 (en) 2010-06-17
MX2011006441A (es) 2011-07-19
CY1113637T1 (el) 2016-06-22
DK2379557T3 (da) 2012-12-17
PL2379557T3 (pl) 2013-03-29
US20100286139A1 (en) 2010-11-11
AU2009330503A1 (en) 2010-07-01
CA2744714C (en) 2013-06-25
EP2379557A1 (en) 2011-10-26
CL2011001445A1 (es) 2011-11-11
BRPI0923048A2 (pt) 2018-09-25
WO2010074947A1 (en) 2010-07-01
JP5509217B2 (ja) 2014-06-04
CN102232075B (zh) 2013-12-11
JO2833B1 (en) 2014-09-15
MY158691A (en) 2016-10-31
KR101300458B1 (ko) 2013-08-30
PT2379557E (pt) 2013-01-14
JP2012512158A (ja) 2012-05-31
AR074240A1 (es) 2011-01-05
EA019554B1 (ru) 2014-04-30
HN2011001697A (es) 2013-11-26
KR20110084993A (ko) 2011-07-26
SG172202A1 (en) 2011-07-28
ES2396617T3 (es) 2013-02-22
ZA201103942B (en) 2012-08-29
DOP2011000190A (es) 2011-07-31
IL213065A0 (en) 2011-07-31
EP2379557B1 (en) 2012-10-31
CN102232075A (zh) 2011-11-02
TW201024301A (en) 2010-07-01
PE20110549A1 (es) 2011-08-04
HRP20120918T1 (hr) 2012-12-31
CR20110341A (es) 2011-07-13
AU2009330503B2 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
PA8851101A1 (es) Compuesto amino pirazol
EA201171367A1 (ru) Винилиндазолильные соединения
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
MX2009012625A (es) Metodos para el tratamiento, diagnostico y deteccion de trastornos asociados con el fgf21.
ECSP11011541A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
MX354099B (es) Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama.
EA200901074A1 (ru) Лечение метастатической стадии рака предстательной железы дегареликсом
EA201400178A1 (ru) Лечение рака молочной железы
MX2010009669A (es) Terapia de combinacion con antagonistas de c-met y egfr.
DOP2010000302A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
MA34598B1 (fr) Procédés et compositions pour traiter le cancer du poumon
EA201101241A1 (ru) Лечение лейкозов и хронических миелопролиферативных болезней антителами к ерна3
ECSP11011021A (es) Antagonistas de la via hedgehog de ftalazina disustituida
EA201890598A2 (ru) Антиандрогены для лечения неметастатического кастрационно-резистентного рака простаты
MX2014006187A (es) Composiciones y metodos para el analisis de cancer de prostata.
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
CL2008001837A1 (es) Uso de compuestos derivados de cinolin-3-carboxamida en el tratamiento de la esquizofrenia.
TN2011000013A1 (en) Amidophenoxyindazoles useful as inhibitors of c-met
UA101379C2 (en) Amidophenoxyindazoles useful in the treatment of cancer
CL2014001265A1 (es) Compuestos derivados de uracilo, inhibidores de la quinasa axl y c-met, utiles en el tratamiento del cancer.
CY1114071T1 (el) Ενωσεις βινυλοϊνδαζολυλιου
EA201391649A1 (ru) Молекула для лечения воспалительного нарушения
UA36281U (ru) Применение винборона как средства для лечения расстройств памяти