AR101504A1 - Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6 - Google Patents
Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6Info
- Publication number
- AR101504A1 AR101504A1 ARP150102591A ARP150102591A AR101504A1 AR 101504 A1 AR101504 A1 AR 101504A1 AR P150102591 A ARP150102591 A AR P150102591A AR P150102591 A ARP150102591 A AR P150102591A AR 101504 A1 AR101504 A1 AR 101504A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitor
- hydrates
- prodrugs
- solvates
- crystals
- Prior art date
Links
- 229940124291 BTK inhibitor Drugs 0.000 title abstract 6
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 title abstract 2
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 title abstract 2
- 239000012828 PI3K inhibitor Substances 0.000 title abstract 2
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000013078 crystal Substances 0.000 abstract 8
- 150000004677 hydrates Chemical class 0.000 abstract 8
- 229940002612 prodrug Drugs 0.000 abstract 8
- 239000000651 prodrug Substances 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 8
- 239000012453 solvate Substances 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 5
- 229940125814 BTK kinase inhibitor Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 102000016736 Cyclin Human genes 0.000 abstract 2
- 108050006400 Cyclin Proteins 0.000 abstract 2
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 abstract 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102100029823 Tyrosine-protein kinase BTK Human genes 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 2
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229960000106 biosimilars Drugs 0.000 abstract 1
- 238000011260 co-administration Methods 0.000 abstract 1
- -1 derivatives Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229960003347 obinutuzumab Drugs 0.000 abstract 1
- 229960002450 ofatumumab Drugs 0.000 abstract 1
- 229950011410 pacritinib Drugs 0.000 abstract 1
- HWXVIOGONBBTBY-ONEGZZNKSA-N pacritinib Chemical compound C=1C=C(C=2)NC(N=3)=NC=CC=3C(C=3)=CC=CC=3COC\C=C\COCC=2C=1OCCN1CCCC1 HWXVIOGONBBTBY-ONEGZZNKSA-N 0.000 abstract 1
- AHJRHEGDXFFMBM-UHFFFAOYSA-N palbociclib Chemical group N1=C2N(C3CCCC3)C(=O)C(C(=O)C)=C(C)C2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 AHJRHEGDXFFMBM-UHFFFAOYSA-N 0.000 abstract 1
- 229960004390 palbociclib Drugs 0.000 abstract 1
- 229960004641 rituximab Drugs 0.000 abstract 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical group C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 abstract 1
- 229960000215 ruxolitinib Drugs 0.000 abstract 1
- 229960005267 tositumomab Drugs 0.000 abstract 1
- 229950000815 veltuzumab Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un método de tratamiento un cáncer, que comprende la coadministración a un mamífero que lo necesita de una o más composiciones que comprenden cantidades terapéuticamente efectivas de (I) inhibidor de la quinasa 4/6 dependiente de ciclina (CDK4/6) o una de sus sales, solvatos, hidratos, cocristales o profármacos farmacéuticamente aceptables y (II) un inhibidor de la tirosina quinasa de Bruton (BTK) o una de sus sales, solvatos, hidratos, cocristales o profármacos farmacéuticamente aceptables. Reivindicación 7: El método de acuerdo con una de las reivindicaciones 1 a 6, en donde el inhibidor de BTK se selecciona del grupo que consiste en: el grupo de fórmulas (1), y sus sales, cocristales, hidratos, solvatos o profármacos farmacéuticamente aceptables. Reivindicación 8: El método de acuerdo con la reivindicación 7, que también comprende la etapa de administración de una dosis terapéuticamente efectiva de un anticuerpo anti-CD20 seleccionado del grupo que consiste en rituximab, obinutuzumab, ofatumumab, veltuzumab, tositumomab, ibritumomab y sus fragmentos, derivados, conjugados, variantes, complejos rotulados con radioisótopos y biosimilares. Reivindicación 10: El método de acuerdo con cualquiera de las reivindicaciones 1 - 9, en donde el inhibidor de CDK4/6 es palbociclib de fórmula (2), de sus sales, cocristales, hidratos, solvatos o profármacos farmacéuticamente aceptables. Reivindicación 14: El método de acuerdo con una de las reivindicaciones 2 a 13, en donde el inhibidor de PI3K se selecciona del grupo que consiste en: el grupo de fórmulas (3), y sus sales, solvatos, hidratos, cocristales o profármacos farmacéuticamente aceptables. Reivindicación 34: Una composición que comprende cantidades terapéuticamente efectivas de (I) un inhibidor de la quinasa 4/6 dependiente de ciclina (CDK4/6) o una de sus sales, solvatos, hidratos, cocristales o profármacos farmacéuticamente aceptables y (II) un inhibidor de la tirosina quinasa de Bruton (BTK) o una de sus sales, solvatos, hidratos, cocristales o profármacos farmacéuticamente aceptables, para usar en el tratamiento de cáncer. Reivindicación 49: La composición de acuerdo con la reivindicación 48, en donde el inhibidor de JAK-2 se selecciona del grupo que consiste en ruxolitinib: de fórmula (4), pacritinib: de fórmula (5), y sus sales, cocristales, hidratos, solvatos o profármacos farmacéuticamente aceptables.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035806P | 2014-08-11 | 2014-08-11 | |
| US201462088371P | 2014-12-05 | 2014-12-05 | |
| US201562115512P | 2015-02-12 | 2015-02-12 | |
| US201562181163P | 2015-06-17 | 2015-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR101504A1 true AR101504A1 (es) | 2016-12-21 |
Family
ID=53969402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150102591A AR101504A1 (es) | 2014-08-11 | 2015-08-11 | Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20170224819A1 (es) |
| AR (1) | AR101504A1 (es) |
| TW (1) | TW201618773A (es) |
| WO (1) | WO2016024232A1 (es) |
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| EP3179991B1 (en) | 2014-08-11 | 2021-10-06 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2017197904A2 (zh) * | 2016-05-08 | 2017-11-23 | 上海诚妙医药科技有限公司 | 帕布昔利布的新晶型及其制备方法及其用途 |
| MX2018014577A (es) * | 2016-05-27 | 2019-05-20 | Tg Therapeutics Inc | Combinacion de anticuerpo anti-cd20, inhibidor selectivo de quinasa p13-delta, e inhibidor de btk para tratar trastornos proliferativos de celulas b. |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| WO2019010369A1 (en) * | 2017-07-07 | 2019-01-10 | Allena Pharmaceuticals, Inc. | RECOMBINANT ENZYME URICASE |
| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| WO2019228406A1 (en) * | 2018-05-29 | 2019-12-05 | Wuxi Biologics (Shanghai) Co., Ltd. | A novel anti-cd3/anti-cd20 bispecific antibody |
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| WO2020239051A1 (zh) * | 2019-05-30 | 2020-12-03 | 江苏恒瑞医药股份有限公司 | Cdk4/6抑制剂与vegfr抑制剂联合在制备治疗肿瘤的药物中的用途 |
| US12312354B2 (en) | 2019-06-25 | 2025-05-27 | San Diego State University (Sdsu) Foundation | Selective BTK irreversible inhibitors |
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| CA3177830A1 (en) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| US20230181581A1 (en) * | 2020-05-26 | 2023-06-15 | Alexion Pharmaceuticals, Inc. | Circulating b cell subpopulations in indolent b cell lymphoma |
| EP4259659A4 (en) * | 2020-12-08 | 2025-02-12 | Cornell University | METHODS FOR INDUCING AN IMMUNOMODULATORY TUMOR RESPONSE |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
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| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
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-
2015
- 2015-08-11 AR ARP150102591A patent/AR101504A1/es unknown
- 2015-08-11 WO PCT/IB2015/056128 patent/WO2016024232A1/en not_active Ceased
- 2015-08-11 TW TW104126106A patent/TW201618773A/zh unknown
- 2015-08-11 US US15/503,224 patent/US20170224819A1/en not_active Abandoned
-
2018
- 2018-05-17 US US15/982,569 patent/US20180250400A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170224819A1 (en) | 2017-08-10 |
| TW201618773A (zh) | 2016-06-01 |
| WO2016024232A1 (en) | 2016-02-18 |
| US20180250400A1 (en) | 2018-09-06 |
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