DOP2010000302A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Info

Publication number
DOP2010000302A
DOP2010000302A DO2010000302A DO2010000302A DOP2010000302A DO P2010000302 A DOP2010000302 A DO P2010000302A DO 2010000302 A DO2010000302 A DO 2010000302A DO 2010000302 A DO2010000302 A DO 2010000302A DO P2010000302 A DOP2010000302 A DO P2010000302A
Authority
DO
Dominican Republic
Prior art keywords
hedgehog
trajectory
antagonists
ftalazina
disttituted
Prior art date
Application number
DO2010000302A
Other languages
English (en)
Inventor
Philip Arthur Hipskind
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2010000302A publication Critical patent/DOP2010000302A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos antagonistas de la trayectoria de hedgehog de ftalazina 1,4 disustituida, útiles en el tratamiento de cáncer
DO2010000302A 2008-04-29 2010-10-11 Antagonistas de la trayectoria hedgehog de ftalazina disustituida DOP2010000302A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29

Publications (1)

Publication Number Publication Date
DOP2010000302A true DOP2010000302A (es) 2010-11-15

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000302A DOP2010000302A (es) 2008-04-29 2010-10-11 Antagonistas de la trayectoria hedgehog de ftalazina disustituida

Country Status (22)

Country Link
US (1) US7981892B2 (es)
EP (1) EP2294061A2 (es)
JP (1) JP5442717B2 (es)
KR (1) KR101260116B1 (es)
CN (1) CN102066353B (es)
AU (1) AU2009241561B2 (es)
BR (1) BRPI0911618A2 (es)
CA (1) CA2723042A1 (es)
CO (1) CO6300945A2 (es)
CR (1) CR11741A (es)
DO (1) DOP2010000302A (es)
EA (1) EA201071248A1 (es)
EC (1) ECSP10010577A (es)
HN (1) HN2010002157A (es)
IL (1) IL208211A0 (es)
MA (1) MA32349B1 (es)
MX (1) MX2010011948A (es)
MY (1) MY159491A (es)
NZ (1) NZ588001A (es)
UA (1) UA102250C2 (es)
WO (1) WO2009134574A2 (es)
ZA (1) ZA201006695B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0911618A2 (pt) 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
CN102202737B (zh) * 2008-11-03 2014-03-26 伊莱利利公司 二取代的2,3-二氮杂萘hedgehog通路拮抗剂
MX2011005176A (es) * 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
JP5518887B2 (ja) 2008-11-17 2014-06-11 イーライ リリー アンド カンパニー 四置換ピリダジンヘッジホッグ経路アンタゴニスト
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2011062939A1 (en) * 2009-11-18 2011-05-26 Novartis Ag Methods and compositions for treating solid tumors and other malignancies
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
WO2014043608A2 (en) * 2012-09-17 2014-03-20 Duke University Smoothened modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
NZ326354A (en) 1996-01-15 1999-05-28 Janssen Pharmaceutica Nv 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1067939B1 (en) 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
GB0013674D0 (en) 1999-06-08 2000-07-26 Lorantis Ltd Therapeutic use
AU2003231032B2 (en) 2002-04-22 2008-07-10 Johns Hopkins University School Of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
AU2005260102A1 (en) 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
KR20170001725A (ko) * 2004-09-02 2017-01-04 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
US8536168B2 (en) 2007-03-15 2013-09-17 Novartis Ag Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway
CA2690378A1 (en) * 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
BRPI0911618A2 (pt) 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN102202737B (zh) 2008-11-03 2014-03-26 伊莱利利公司 二取代的2,3-二氮杂萘hedgehog通路拮抗剂
MX2011005176A (es) 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
JP5518887B2 (ja) 2008-11-17 2014-06-11 イーライ リリー アンド カンパニー 四置換ピリダジンヘッジホッグ経路アンタゴニスト
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
US20110046143A1 (en) 2011-02-24
CN102066353A (zh) 2011-05-18
AU2009241561B2 (en) 2013-05-16
CA2723042A1 (en) 2009-11-05
UA102250C2 (ru) 2013-06-25
CN102066353B (zh) 2013-12-11
KR101260116B1 (ko) 2013-05-02
HN2010002157A (es) 2014-09-08
EA201071248A1 (ru) 2011-06-30
WO2009134574A2 (en) 2009-11-05
EP2294061A2 (en) 2011-03-16
MX2010011948A (es) 2010-12-14
AU2009241561A1 (en) 2009-11-05
MY159491A (en) 2017-01-13
NZ588001A (en) 2012-06-29
ECSP10010577A (es) 2010-11-30
KR20100126580A (ko) 2010-12-01
IL208211A0 (en) 2010-12-30
CO6300945A2 (es) 2011-07-21
JP5442717B2 (ja) 2014-03-12
MA32349B1 (fr) 2011-06-01
JP2011527666A (ja) 2011-11-04
WO2009134574A3 (en) 2014-09-04
ZA201006695B (en) 2012-09-26
US7981892B2 (en) 2011-07-19
BRPI0911618A2 (pt) 2019-09-24
CR11741A (es) 2011-01-05

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