MA32349B1 - Antagonistes de la voie hedgehog a base de phtalazines disubstituees - Google Patents

Antagonistes de la voie hedgehog a base de phtalazines disubstituees

Info

Publication number
MA32349B1
MA32349B1 MA33284A MA33284A MA32349B1 MA 32349 B1 MA32349 B1 MA 32349B1 MA 33284 A MA33284 A MA 33284A MA 33284 A MA33284 A MA 33284A MA 32349 B1 MA32349 B1 MA 32349B1
Authority
MA
Morocco
Prior art keywords
antagonists
phtalazines
disubstituted
hedgehog pathway
pathway based
Prior art date
Application number
MA33284A
Other languages
Arabic (ar)
English (en)
Inventor
Philip Arthur Hipskind
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA32349B1 publication Critical patent/MA32349B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La présente invention concerne de nouveaux antagonistes de la voie de la protéine hedgehog de phtalazine 1,4-disubstituée utiles dans le traitement du cancer.
MA33284A 2008-04-29 2010-10-25 Antagonistes de la voie hedgehog a base de phtalazines disubstituees MA32349B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29
PCT/US2009/039065 WO2009134574A2 (fr) 2008-04-29 2009-04-01 Antagonistes de la voie de la protéine hedgehog de phtalazine disubstituée

Publications (1)

Publication Number Publication Date
MA32349B1 true MA32349B1 (fr) 2011-06-01

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33284A MA32349B1 (fr) 2008-04-29 2010-10-25 Antagonistes de la voie hedgehog a base de phtalazines disubstituees

Country Status (22)

Country Link
US (1) US7981892B2 (fr)
EP (1) EP2294061A2 (fr)
JP (1) JP5442717B2 (fr)
KR (1) KR101260116B1 (fr)
CN (1) CN102066353B (fr)
AU (1) AU2009241561B2 (fr)
BR (1) BRPI0911618A2 (fr)
CA (1) CA2723042A1 (fr)
CO (1) CO6300945A2 (fr)
CR (1) CR11741A (fr)
DO (1) DOP2010000302A (fr)
EA (1) EA201071248A1 (fr)
EC (1) ECSP10010577A (fr)
HN (1) HN2010002157A (fr)
IL (1) IL208211A0 (fr)
MA (1) MA32349B1 (fr)
MX (1) MX2010011948A (fr)
MY (1) MY159491A (fr)
NZ (1) NZ588001A (fr)
UA (1) UA102250C2 (fr)
WO (1) WO2009134574A2 (fr)
ZA (1) ZA201006695B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009241561B2 (en) 2008-04-29 2013-05-16 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
US8404687B2 (en) 2008-11-03 2013-03-26 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
CA2743264C (fr) * 2008-11-17 2014-02-18 Julia Marie Clay Pyridazines tetrasubstituees antagonistes de la voie hedgehog
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
EP2501370A1 (fr) * 2009-11-18 2012-09-26 Novartis AG Procédés et compositions pour traiter des tumeurs solides et d'autres malignités
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
EP2895474B1 (fr) * 2012-09-17 2019-12-11 Duke University Modulateurs du récepteur smoothened et leurs procédés d'utilisation
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
DK0876366T3 (da) 1996-01-15 2001-11-05 Janssen Pharmaceutica Nv Angiogenese-inhiberende pyridazinaminer
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO2000074706A1 (fr) 1999-06-08 2000-12-14 Lorantis Limited Utilisation therapeutique d'un inhibiteur d'un trajet de signalisation du herisson ou apparente au herisson
WO2003088970A2 (fr) 2002-04-22 2003-10-30 Johns Hopkins University School Of Medicine Modulateurs de voies de signalisation hedgehog, compositions et utilisations associees
WO2004020599A2 (fr) 2002-08-29 2004-03-11 Curis, Inc. Antagonistes de la voie hedgehog, methodes et applications correspondantes
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
US8338591B2 (en) 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
UA96565C2 (ru) * 2004-09-02 2011-11-25 Дженентек, Инк. Пиридильные ингибиторы хеджхоговской передачи сигнала
EP1900731A1 (fr) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amides comme modulateurs du récepteur EP2
MY156814A (en) 2007-03-15 2016-03-31 Novartis Ag Organic compounds and their uses
AU2008269128B2 (en) * 2007-06-25 2012-08-02 Amgen Inc. Phthalazine compounds, compositions and methods of use
EP2188283B1 (fr) 2007-09-07 2012-08-15 Amgen Inc. Pyridazines annelées destinées au traitement de tumeurs induites par une signalisation hedgehog inadaptée
AU2009241561B2 (en) 2008-04-29 2013-05-16 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8404687B2 (en) 2008-11-03 2013-03-26 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
CA2743264C (fr) 2008-11-17 2014-02-18 Julia Marie Clay Pyridazines tetrasubstituees antagonistes de la voie hedgehog
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
AU2009241561B2 (en) 2013-05-16
US20110046143A1 (en) 2011-02-24
JP5442717B2 (ja) 2014-03-12
ZA201006695B (en) 2012-09-26
CN102066353A (zh) 2011-05-18
WO2009134574A3 (fr) 2014-09-04
ECSP10010577A (es) 2010-11-30
AU2009241561A1 (en) 2009-11-05
WO2009134574A2 (fr) 2009-11-05
HN2010002157A (es) 2014-09-08
US7981892B2 (en) 2011-07-19
CA2723042A1 (fr) 2009-11-05
UA102250C2 (ru) 2013-06-25
KR101260116B1 (ko) 2013-05-02
BRPI0911618A2 (pt) 2019-09-24
IL208211A0 (en) 2010-12-30
CN102066353B (zh) 2013-12-11
MX2010011948A (es) 2010-12-14
MY159491A (en) 2017-01-13
JP2011527666A (ja) 2011-11-04
CO6300945A2 (es) 2011-07-21
DOP2010000302A (es) 2010-11-15
EA201071248A1 (ru) 2011-06-30
CR11741A (es) 2011-01-05
KR20100126580A (ko) 2010-12-01
EP2294061A2 (fr) 2011-03-16
NZ588001A (en) 2012-06-29

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