EA201170699A1 - Тетразамещенные пиридазины в качестве антагонистов пути hedgehog - Google Patents

Тетразамещенные пиридазины в качестве антагонистов пути hedgehog

Info

Publication number
EA201170699A1
EA201170699A1 EA201170699A EA201170699A EA201170699A1 EA 201170699 A1 EA201170699 A1 EA 201170699A1 EA 201170699 A EA201170699 A EA 201170699A EA 201170699 A EA201170699 A EA 201170699A EA 201170699 A1 EA201170699 A1 EA 201170699A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hedgehog
antagonists
tetra
way
substituted pyridazines
Prior art date
Application number
EA201170699A
Other languages
English (en)
Other versions
EA017386B1 (ru
Inventor
Джоли Энн Бастиан
Джулия Мари Клэй
Джеффри Дэниел Коэн
Филип Артур Хипскинд
Карен Линн Лобб
Дэниел Джон Сэлл
Уилсон (Ни Такакува), Такако
Майкл Ли Томпсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201170699A1 publication Critical patent/EA201170699A1/ru
Publication of EA017386B1 publication Critical patent/EA017386B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящем изобретении предложены новые тетразамещенные пиридазины в качестве антагонистов пути hedgehog, подходящие для лечения рака.
EA201170699A 2008-11-17 2009-11-05 Тетразамещенные пиридазины в качестве антагонистов пути hedgehog EA017386B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11533208P 2008-11-17 2008-11-17
PCT/US2009/063370 WO2010056588A1 (en) 2008-11-17 2009-11-05 Tetrasubstituted pyridazine hedgehog pathway antagonists

Publications (2)

Publication Number Publication Date
EA201170699A1 true EA201170699A1 (ru) 2011-12-30
EA017386B1 EA017386B1 (ru) 2012-12-28

Family

ID=41722877

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170699A EA017386B1 (ru) 2008-11-17 2009-11-05 Тетразамещенные пиридазины в качестве антагонистов пути hedgehog

Country Status (18)

Country Link
US (1) US8507490B2 (ru)
EP (1) EP2358698B1 (ru)
JP (1) JP5518887B2 (ru)
KR (1) KR101342184B1 (ru)
CN (1) CN102216285B (ru)
AU (1) AU2009314349B2 (ru)
BR (1) BRPI0921782A2 (ru)
CA (1) CA2743483C (ru)
CY (1) CY1113377T1 (ru)
DK (1) DK2358698T3 (ru)
EA (1) EA017386B1 (ru)
ES (1) ES2392759T3 (ru)
HR (1) HRP20120762T1 (ru)
MX (1) MX2011005177A (ru)
PL (1) PL2358698T3 (ru)
PT (1) PT2358698E (ru)
SI (1) SI2358698T1 (ru)
WO (1) WO2010056588A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2049521A2 (en) * 2006-07-17 2009-04-22 Syngeta Participations AG Novel pyridazine derivatives
EP2294061A2 (en) 2008-04-29 2011-03-16 Eli Lilly & Company Disubstituted phthalazine hedgehog pathway antagonists
AU2009320251C1 (en) 2008-11-03 2013-08-15 Eli Lilly And Company Disubstituted phthalazine Hedgehog pathway antagonists
CN102216292B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
GB201309508D0 (en) 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105130980B (zh) * 2015-09-09 2018-05-22 沈阳药科大学 N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用
CN110208424A (zh) * 2019-06-28 2019-09-06 江苏恒生检测有限公司 一种农药氟啶虫酰胺中含有杂质的分析方法
WO2021071981A1 (en) * 2019-10-08 2021-04-15 Skyhawk Therapeutics, Inc. Compounds for modulating splicing
WO2023034836A1 (en) * 2021-08-30 2023-03-09 Remix Therapeutics Inc. Compounds and methods for modulating splicing

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
ZA97288B (en) 1996-01-15 1998-07-14 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
AU768130B2 (en) 1998-04-09 2003-12-04 Johns Hopkins University School Of Medicine, The Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
AU780358B2 (en) 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
WO2003088970A2 (en) 2002-04-22 2003-10-30 Johns Hopkins University School Of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
AU2005260102A1 (en) 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
SI1789390T1 (sl) 2004-09-02 2012-05-31 Genentech Inc Piridilni inhibitorji hedgehog signalizacije
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
JP5550352B2 (ja) * 2007-03-15 2014-07-16 ノバルティス アーゲー 有機化合物およびその使用
CA2690378A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
US8222251B2 (en) 2007-09-07 2012-07-17 Amgen Inc. Pyridopyridazine compounds, compositions and methods of use
EP2294061A2 (en) 2008-04-29 2011-03-16 Eli Lilly & Company Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
AU2009320251C1 (en) 2008-11-03 2013-08-15 Eli Lilly And Company Disubstituted phthalazine Hedgehog pathway antagonists
CN102216292B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
US8507490B2 (en) 2013-08-13
EP2358698A1 (en) 2011-08-24
SI2358698T1 (sl) 2012-11-30
MX2011005177A (es) 2011-05-30
BRPI0921782A2 (pt) 2019-09-24
ES2392759T3 (es) 2012-12-13
WO2010056588A1 (en) 2010-05-20
PL2358698T3 (pl) 2013-01-31
EP2358698B1 (en) 2012-09-05
DK2358698T3 (da) 2012-10-08
AU2009314349A1 (en) 2010-05-20
JP2012509263A (ja) 2012-04-19
EA017386B1 (ru) 2012-12-28
CY1113377T1 (el) 2016-06-22
PT2358698E (pt) 2012-10-24
CA2743483A1 (en) 2010-05-20
CN102216285B (zh) 2014-08-13
JP5518887B2 (ja) 2014-06-11
CA2743483C (en) 2014-03-11
US20110263602A1 (en) 2011-10-27
HRP20120762T1 (hr) 2012-10-31
AU2009314349B2 (en) 2013-04-18
KR20110070920A (ko) 2011-06-24
KR101342184B1 (ko) 2013-12-19
CN102216285A (zh) 2011-10-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU