BRPI0911618A2 - antagonistas da via hedgehog de ftalazina dissubstituída. - Google Patents

antagonistas da via hedgehog de ftalazina dissubstituída.

Info

Publication number
BRPI0911618A2
BRPI0911618A2 BRPI0911618A BRPI0911618A BRPI0911618A2 BR PI0911618 A2 BRPI0911618 A2 BR PI0911618A2 BR PI0911618 A BRPI0911618 A BR PI0911618A BR PI0911618 A BRPI0911618 A BR PI0911618A BR PI0911618 A2 BRPI0911618 A2 BR PI0911618A2
Authority
BR
Brazil
Prior art keywords
disrupted
hedgehog pathway
pathway antagonists
phthalazine
phthalazine hedgehog
Prior art date
Application number
BRPI0911618A
Other languages
English (en)
Inventor
Arthur Hipskind Philip
Wilson Takako
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0911618A2 publication Critical patent/BRPI0911618A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0911618A 2008-04-29 2009-04-01 antagonistas da via hedgehog de ftalazina dissubstituída. BRPI0911618A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4872908P 2008-04-29 2008-04-29
PCT/US2009/039065 WO2009134574A2 (en) 2008-04-29 2009-04-01 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
BRPI0911618A2 true BRPI0911618A2 (pt) 2019-09-24

Family

ID=40846962

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911618A BRPI0911618A2 (pt) 2008-04-29 2009-04-01 antagonistas da via hedgehog de ftalazina dissubstituída.

Country Status (22)

Country Link
US (1) US7981892B2 (pt)
EP (1) EP2294061A2 (pt)
JP (1) JP5442717B2 (pt)
KR (1) KR101260116B1 (pt)
CN (1) CN102066353B (pt)
AU (1) AU2009241561B2 (pt)
BR (1) BRPI0911618A2 (pt)
CA (1) CA2723042A1 (pt)
CO (1) CO6300945A2 (pt)
CR (1) CR11741A (pt)
DO (1) DOP2010000302A (pt)
EA (1) EA201071248A1 (pt)
EC (1) ECSP10010577A (pt)
HN (1) HN2010002157A (pt)
IL (1) IL208211A0 (pt)
MA (1) MA32349B1 (pt)
MX (1) MX2010011948A (pt)
MY (1) MY159491A (pt)
NZ (1) NZ588001A (pt)
UA (1) UA102250C2 (pt)
WO (1) WO2009134574A2 (pt)
ZA (1) ZA201006695B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0911618A2 (pt) 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
PT2364185E (pt) * 2008-11-03 2013-07-24 Lilly Co Eli Ftalazina dissubstituída antagonista da via hedgehog
CN102216285B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
MX2011005176A (es) * 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
BR112012011823A2 (pt) * 2009-11-18 2019-09-24 Novartis Ag métodos e composições para tratar tumores sólidos e outras malignidades
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
EP2895474B1 (en) * 2012-09-17 2019-12-11 Duke University Smoothened receptor modulators and methods of use thereof
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN107163028B (zh) * 2017-05-24 2019-07-12 东南大学 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
IL138645A0 (en) 1998-04-09 2001-10-31 Univ Johns Hopkins Med Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways
AU780358B2 (en) 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
ATE404200T1 (de) 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
EP1745039A4 (en) 2004-05-08 2009-07-22 Neurogen Corp 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES
CN102964294A (zh) * 2004-09-02 2013-03-13 遗传技术研究公司 Hedgehog信号转导的吡啶基抑制剂
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
PE20090188A1 (es) * 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
WO2009002469A1 (en) * 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
BRPI0911618A2 (pt) 2008-04-29 2019-09-24 Lilly Co Eli antagonistas da via hedgehog de ftalazina dissubstituída.
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
PT2364185E (pt) 2008-11-03 2013-07-24 Lilly Co Eli Ftalazina dissubstituída antagonista da via hedgehog
MX2011005176A (es) 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
CN102216285B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
JP5442717B2 (ja) 2014-03-12
KR20100126580A (ko) 2010-12-01
CA2723042A1 (en) 2009-11-05
ZA201006695B (en) 2012-09-26
EA201071248A1 (ru) 2011-06-30
HN2010002157A (es) 2014-09-08
CN102066353A (zh) 2011-05-18
US20110046143A1 (en) 2011-02-24
US7981892B2 (en) 2011-07-19
ECSP10010577A (es) 2010-11-30
JP2011527666A (ja) 2011-11-04
MY159491A (en) 2017-01-13
WO2009134574A2 (en) 2009-11-05
KR101260116B1 (ko) 2013-05-02
NZ588001A (en) 2012-06-29
EP2294061A2 (en) 2011-03-16
MA32349B1 (fr) 2011-06-01
AU2009241561B2 (en) 2013-05-16
CR11741A (es) 2011-01-05
CN102066353B (zh) 2013-12-11
CO6300945A2 (es) 2011-07-21
AU2009241561A1 (en) 2009-11-05
IL208211A0 (en) 2010-12-30
WO2009134574A3 (en) 2014-09-04
UA102250C2 (ru) 2013-06-25
MX2010011948A (es) 2010-12-14
DOP2010000302A (es) 2010-11-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.