MA30912B1 - Nouveaux derives de phenylsulfamoyl-benzamide en tant qu'antagonistes de la bradykinine - Google Patents

Nouveaux derives de phenylsulfamoyl-benzamide en tant qu'antagonistes de la bradykinine

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Publication number
MA30912B1
MA30912B1 MA31907A MA31907A MA30912B1 MA 30912 B1 MA30912 B1 MA 30912B1 MA 31907 A MA31907 A MA 31907A MA 31907 A MA31907 A MA 31907A MA 30912 B1 MA30912 B1 MA 30912B1
Authority
MA
Morocco
Prior art keywords
phenylsulfamoyl
novel
benzamide derivatives
antagonists
bradykinine
Prior art date
Application number
MA31907A
Other languages
English (en)
Inventor
Gyula Beke
Eva Bozo
Sandor Farkas
Katalin Hornok
Gyoergy Keserue
Eva Schmidt
Eva Szentirmay
Istvan Vago
Monika Vastag
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA30912B1 publication Critical patent/MA30912B1/fr

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX DÉRIVÉS DE SULFONAMIDE DE FORMULE (I), DANS LAQUELLE R1 À R8 ET Z SONT TELS QUE DÉFINIS DANS LES REVENDICATIONS; ET DES ANTIPODES OU RACÉMATES OPTIQUES ET/OU LEURS SELS ET/OU HYDRATES ET/OU SOLVATES, QUI SONT DES ANTAGONISTES SÉLECTIFS DE LA BRADYQUININE B1. ELLLE CONCERNE DES MÉTHODES DE PRODUCTION DESDITS COMPOSÉS, DES COMPOSITIONS PHARMACOLOGIQUES CONTENANT CES COMPOSÉS, ET L'UTILISATION DE CES COMPOSÉS POUR LE TRAITEMENT OU LA PRÉVENTION D'ÉTATS DOULOUREUX OU INFLAMMATOIRES.
MA31907A 2006-10-27 2009-05-21 Nouveaux derives de phenylsulfamoyl-benzamide en tant qu'antagonistes de la bradykinine MA30912B1 (fr)

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HU0600809A HUP0600809A3 (en) 2006-10-27 2006-10-27 New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them

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MA30912B1 true MA30912B1 (fr) 2009-11-02

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EP (1) EP2057116B1 (fr)
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KR (1) KR20090076926A (fr)
CN (1) CN101528680A (fr)
AU (1) AU2007310587A1 (fr)
BR (1) BRPI0718494A2 (fr)
CA (1) CA2667481C (fr)
EA (1) EA018032B1 (fr)
GE (1) GEP20125393B (fr)
HU (1) HUP0600809A3 (fr)
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MX (1) MX2009004528A (fr)
MY (1) MY155039A (fr)
NO (1) NO20092049L (fr)
NZ (1) NZ575765A (fr)
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WO (1) WO2008050167A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
WO2009027450A1 (fr) 2007-08-29 2009-03-05 Boehringer Ingelheim International Gmbh Nouveaux antagonistes de la bradykinine b1
US20100298299A1 (en) * 2007-10-27 2010-11-25 Istvan Vago non-peptide derivatives as bradykinin b1 antagonists
EP2330899A1 (fr) * 2008-08-21 2011-06-15 Richter Gedeon Nyrt. Procédé de traitement de douleur neuropathique
US20100048630A1 (en) * 2008-08-21 2010-02-25 Pradeep Banerjee Methods for treating cns disorders
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
CN102414177B (zh) * 2009-02-26 2014-07-02 贝林格尔.英格海姆国际有限公司 作为缓激肽b1拮抗剂的化合物
CA2790952C (fr) * 2010-02-23 2017-07-04 Boehringer Ingelheim International Gmbh Composes en tant qu'antagonistes de la bradykinine b1
US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
CN104151248B (zh) * 2014-07-17 2016-02-17 陕西师范大学 双咪唑丹磺酰衍生物阳离子型荧光探针及其合成方法和应用
CN104693075B (zh) * 2015-02-13 2016-05-11 程涛 p18小分子抑制剂及在人造血干细胞体外扩增中的用途
CN106601606B (zh) * 2015-10-19 2019-09-20 中芯国际集成电路制造(上海)有限公司 Nmos器件、半导体装置及其制造方法
TW202202495A (zh) 2020-03-26 2022-01-16 匈牙利商羅特格登公司 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物
KR20210150011A (ko) * 2020-06-03 2021-12-10 주식회사 삼오파마켐 프로베네시드 및 아르기닌의 아미드 유도체, 이를 포함하는 약제학적 조성물 및 이의 제조 방법
HUP2100338A1 (hu) 2021-09-29 2023-04-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
US5714497A (en) * 1993-02-15 1998-02-03 Sanofi Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them
US6451816B1 (en) * 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624668A1 (de) * 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
BR9814645A (pt) * 1997-11-18 2001-07-31 Teijin Ltd Derivados de amina cìclica e seu uso como medicamentos
GB9804885D0 (en) * 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
US6017961A (en) * 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
US6638950B2 (en) * 2000-06-21 2003-10-28 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
SI1409477T1 (sl) * 2001-07-24 2009-02-28 Richter Gedeon Nyrt Derivati piperidina kot antagonisti nmda-receptorjev
US7393873B2 (en) * 2003-07-02 2008-07-01 Merck & Co., Inc. Arylsulfonamide derivatives
US20070105902A1 (en) * 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
HU230518B1 (hu) * 2005-12-20 2016-10-28 Richter Gedeon Nyrt. Bradykinin B1 receptor szelektív antagonista hatással rendelkező új fenatridin származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
US20100298299A1 (en) * 2007-10-27 2010-11-25 Istvan Vago non-peptide derivatives as bradykinin b1 antagonists
EP2330899A1 (fr) * 2008-08-21 2011-06-15 Richter Gedeon Nyrt. Procédé de traitement de douleur neuropathique
US20100048630A1 (en) * 2008-08-21 2010-02-25 Pradeep Banerjee Methods for treating cns disorders

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US20120295910A1 (en) 2012-11-22
KR20090076926A (ko) 2009-07-13
MX2009004528A (es) 2009-07-02
EA018032B1 (ru) 2013-05-30
EA200900605A1 (ru) 2009-08-28
HU0600809D0 (en) 2006-12-28
HUP0600809A3 (en) 2008-09-29
EP2057116A1 (fr) 2009-05-13
US20100105686A1 (en) 2010-04-29
CN101528680A (zh) 2009-09-09
HUP0600809A2 (en) 2008-08-28
JP2010507643A (ja) 2010-03-11
GEP20125393B (en) 2012-02-10
NO20092049L (no) 2009-07-17
NZ575765A (en) 2011-12-22
BRPI0718494A2 (pt) 2014-01-21
AU2007310587A1 (en) 2008-05-02
CA2667481C (fr) 2012-09-25
EP2057116B1 (fr) 2013-02-13
CA2667481A1 (fr) 2008-05-02
WO2008050167A1 (fr) 2008-05-02
US20130029991A1 (en) 2013-01-31
MY155039A (en) 2015-08-28
IL197586A0 (en) 2009-12-24
TN2009000108A1 (en) 2010-08-19

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