PL2010498T3 - Sposób otrzymywania acyloaminoalkilenoamidów użytecznych jako antagoniści substancji P - Google Patents
Sposób otrzymywania acyloaminoalkilenoamidów użytecznych jako antagoniści substancji PInfo
- Publication number
- PL2010498T3 PL2010498T3 PL07724154T PL07724154T PL2010498T3 PL 2010498 T3 PL2010498 T3 PL 2010498T3 PL 07724154 T PL07724154 T PL 07724154T PL 07724154 T PL07724154 T PL 07724154T PL 2010498 T3 PL2010498 T3 PL 2010498T3
- Authority
- PL
- Poland
- Prior art keywords
- acylaminoalkenylene
- antagonists
- synthesis
- substance
- amides useful
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003890 substance P antagonist Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
| GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
| EP07724154A EP2010498B1 (en) | 2006-04-13 | 2007-04-11 | Synthesis of acylaminoalkenylene amides useful as substance p antagonists |
| PCT/EP2007/003213 WO2007118651A1 (en) | 2006-04-13 | 2007-04-11 | Synthesis of acylaminoalkenylene amides useful as substance p antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2010498T3 true PL2010498T3 (pl) | 2011-04-29 |
Family
ID=38324102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07724154T PL2010498T3 (pl) | 2006-04-13 | 2007-04-11 | Sposób otrzymywania acyloaminoalkilenoamidów użytecznych jako antagoniści substancji P |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8008479B2 (pl) |
| EP (1) | EP2010498B1 (pl) |
| JP (1) | JP5208917B2 (pl) |
| KR (1) | KR20080108291A (pl) |
| AR (1) | AR060506A1 (pl) |
| AT (1) | ATE486853T1 (pl) |
| AU (1) | AU2007237482B2 (pl) |
| CA (1) | CA2645362C (pl) |
| CL (1) | CL2007001040A1 (pl) |
| CY (1) | CY1111294T1 (pl) |
| DE (1) | DE602007010269D1 (pl) |
| DK (1) | DK2010498T3 (pl) |
| EC (1) | ECSP088820A (pl) |
| GT (1) | GT200800209A (pl) |
| HR (1) | HRP20110045T1 (pl) |
| JO (1) | JO2630B1 (pl) |
| MA (1) | MA30394B1 (pl) |
| MX (1) | MX2008013117A (pl) |
| MY (1) | MY145069A (pl) |
| NO (1) | NO20084783L (pl) |
| NZ (1) | NZ571142A (pl) |
| PE (1) | PE20071223A1 (pl) |
| PL (1) | PL2010498T3 (pl) |
| PT (1) | PT2010498E (pl) |
| RU (1) | RU2433122C2 (pl) |
| SI (1) | SI2010498T1 (pl) |
| TW (1) | TW200815358A (pl) |
| WO (1) | WO2007118651A1 (pl) |
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| AU2005295927B2 (en) | 2004-10-12 | 2012-02-02 | Fmc Biopolymer As | Self-gelling alginate systems and uses thereof |
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| US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| US8080549B2 (en) | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
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| US8013007B2 (en) | 2007-02-26 | 2011-09-06 | Concert Pharmaceuticals, Inc. | Alpha 1A-adrenoceptor antagonists |
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| WO2008128166A1 (en) | 2007-04-13 | 2008-10-23 | Concert Pharmaceuticals Inc. | Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds |
| US8349817B2 (en) | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
| EP2152689B1 (en) | 2007-04-25 | 2013-01-02 | Concert Pharmaceuticals Inc. | Analogues of cilostazol |
| PL2345653T3 (pl) | 2007-05-01 | 2013-05-31 | Concert Pharmaceuticals Inc | Związki morfianu |
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| WO2008141021A1 (en) | 2007-05-08 | 2008-11-20 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of tetrahydrotriazolopyrazine compounds and their use as dpp-iv inhibitors |
| ATE536343T1 (de) | 2007-06-12 | 2011-12-15 | Concert Pharmaceuticals Inc | Azapeptid-derivate als hiv-protease-inhibitoren |
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| CN101821260B (zh) | 2007-08-14 | 2013-07-31 | 康塞特医药品有限公司 | 取代的噁唑烷酮衍生物 |
| AU2008296975B2 (en) | 2007-08-28 | 2014-07-24 | Fmc Corporation | Delayed self-gelling alginate systems and uses thereof |
| WO2009035662A1 (en) | 2007-09-12 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated 4 -oxoquinoline derivatives for the treatment of hiv infection |
| AU2008299921B2 (en) | 2007-09-13 | 2012-03-01 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
| US8410124B2 (en) | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
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| EP3199203B1 (en) | 2008-02-29 | 2020-02-05 | Concert Pharmaceuticals Inc. | Substituted xanthine derivatives |
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| KR20110063479A (ko) | 2008-08-29 | 2011-06-10 | 콘서트 파마슈티컬즈, 인크. | 치환된 트리아졸로-피리다진 유도체 |
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| DE102009001446A1 (de) | 2009-03-10 | 2010-09-23 | Evonik Rohmax Additives Gmbh | Verwendung von Kammpolymeren als Antifatigue-Additive |
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| JP2014513046A (ja) | 2011-02-14 | 2014-05-29 | コンサート ファーマシューティカルズ インコーポレイテッド | ４−ヒドロキシ酪酸の重水素化類似体 |
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| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
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| EP2838879A1 (en) | 2012-04-20 | 2015-02-25 | Concert Pharmaceuticals Inc. | Deuterated rigosertib |
| RS67061B1 (sr) | 2012-06-15 | 2025-08-29 | Sun Pharmaceutical Industries Inc | Deuterisani derivati ruksolitiniba |
| US9181190B2 (en) | 2012-07-04 | 2015-11-10 | Concert Pharmaceuticals, Inc. | Deuterated vercirnon |
| US10017445B2 (en) | 2012-07-12 | 2018-07-10 | Concert Pharmaceuticals, Inc. | Deuterated idebenone |
| EA201590296A1 (ru) | 2012-07-30 | 2015-07-30 | Консерт Фармасьютикалс Инк. | Дейтерированный ибрутиниб |
| BR112015003153A2 (pt) | 2012-08-17 | 2017-07-04 | Concert Pharmaceuticals Inc | baricitinib deuterado |
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| WO2015120393A1 (en) | 2014-02-10 | 2015-08-13 | Concert Pharmaceuticals, Inc. | Substituted triazolobenzodiazepines |
| WO2016069630A1 (en) | 2014-10-27 | 2016-05-06 | Concert Pharmaceuticals, Inc. | Pyrimidine phosphonic acid esters bearing at least one deuterium atom |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| WO2016176335A1 (en) | 2015-04-27 | 2016-11-03 | Concert Pharmaceuticals, Inc. | Deuterated otx-015 |
| MA42954A (fr) | 2015-09-25 | 2018-08-01 | Vertex Pharmaceuticals Europe Ltd | Potentialisateurs cftr deutérés |
| EP3377179B1 (en) | 2015-11-19 | 2021-04-07 | Concert Pharmaceuticals Inc. | Deuterated epi-743 |
| US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
| CA3082834A1 (en) | 2017-11-22 | 2019-05-31 | Concert Pharmaceuticals, Inc. | Deuterated analogs of d-serine and uses thereof |
| KR102720000B1 (ko) | 2017-12-01 | 2024-10-21 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막관통 조절 인자의 제조 방법 |
| US12065395B2 (en) | 2019-04-03 | 2024-08-20 | Sun Pharmaceutical Industries, Inc. | Processes for the preparation of deuterated D-serine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA002348B1 (ru) * | 1995-02-22 | 2002-04-25 | Новартис Аг | Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1 |
| MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB0010958D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Ceased
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en not_active Ceased
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en not_active Not-in-force
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2011
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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