MX2010002679A - Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana. - Google Patents

Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana.

Info

Publication number
MX2010002679A
MX2010002679A MX2010002679A MX2010002679A MX2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A
Authority
MX
Mexico
Prior art keywords
derivatives
deuterated
treatment
hiv infection
oxoquinoline
Prior art date
Application number
MX2010002679A
Other languages
English (en)
Inventor
Scott L Harbeson
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Publication of MX2010002679A publication Critical patent/MX2010002679A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos novedosos que son derivados de 4-axoquinolina y a las sales de los mismos farmacéuticamente aceptables. Más específicamente, esta invención se refiere a nuevos derivados de 4-axoquinolina que son derivados de elvitegravir. Esta invención también proporciona composiciones libres de pirógenos que comprenden uno o más compuestos de la invención y un portador, y al uso de los compuestos y composiciones descritos en los métodos de tratamiento de las enfermedades y afecciones que son tratadas benéficamente por la administración de un inhibidor de la integrasa de VIH, tal como elvitegravir.
MX2010002679A 2007-09-12 2008-09-12 Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana. MX2010002679A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99342807P 2007-09-12 2007-09-12
PCT/US2008/010662 WO2009035662A1 (en) 2007-09-12 2008-09-12 Deuterated 4 -oxoquinoline derivatives for the treatment of hiv infection

Publications (1)

Publication Number Publication Date
MX2010002679A true MX2010002679A (es) 2010-03-29

Family

ID=40070844

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002679A MX2010002679A (es) 2007-09-12 2008-09-12 Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana.

Country Status (7)

Country Link
US (1) US7994194B2 (es)
EP (1) EP2197847B1 (es)
AU (1) AU2008299931B2 (es)
CA (1) CA2698825C (es)
ES (1) ES2406479T3 (es)
MX (1) MX2010002679A (es)
WO (1) WO2009035662A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2470365C (en) * 2002-11-20 2011-05-17 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
ES2406479T3 (es) 2007-09-12 2013-06-07 Concert Pharmaceuticals Inc. Derivado deuterado de 4-oxoquinolina para el tratamiento de la infección por VIH
EP2521770B1 (en) 2010-01-08 2015-11-25 Amyris, Inc. Methods for producing isomers of muconic acid and muconate salts
CN103819402B (zh) * 2012-11-17 2016-03-30 上海迪赛诺化学制药有限公司 埃替拉韦中间体及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704035A (en) * 1986-10-06 1987-11-03 Baker Perkins, Inc. Remotely transmitting batch mixer
US4962495A (en) * 1988-10-03 1990-10-09 Lucas Aerospace Power Transmission Corp. Apparatus and method for transmitting condition data from a rotating member to a stationary device
KR20040068613A (ko) 1994-03-25 2004-07-31 이소테크니카 인코포레이티드 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
FR2753648B1 (fr) * 1996-09-26 1998-11-27 Alphacan Sa Procede et installation de fabrication de tubes en matiere plastique avec etirage bi-axial, et tube en matiere plastique ainsi obtenu
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
ES2193921T3 (es) 1999-12-03 2003-11-16 Pfizer Prod Inc Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos.
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
CA2470365C (en) 2002-11-20 2011-05-17 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
JP4629104B2 (ja) 2004-05-21 2011-02-09 日本たばこ産業株式会社 ４−オキソキノリン誘導体および抗ｈｉｖ剤を含む併用剤
US20060058286A1 (en) * 2004-09-16 2006-03-16 Mark Krystal Methods of treating HIV infection
CA2624179A1 (en) 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US20090018162A1 (en) 2006-02-01 2009-01-15 Yuji Matsuzaki Use of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or salt thereof for treating retrovirus infection
US7750168B2 (en) 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
CA2661404A1 (en) 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
ES2406479T3 (es) 2007-09-12 2013-06-07 Concert Pharmaceuticals Inc. Derivado deuterado de 4-oxoquinolina para el tratamiento de la infección por VIH

Also Published As

Publication number Publication date
CA2698825C (en) 2013-08-20
CA2698825A1 (en) 2009-03-19
EP2197847A1 (en) 2010-06-23
AU2008299931A1 (en) 2009-03-19
EP2197847B1 (en) 2012-11-07
US20090143427A1 (en) 2009-06-04
WO2009035662A1 (en) 2009-03-19
ES2406479T3 (es) 2013-06-07
AU2008299931B2 (en) 2013-01-10
US7994194B2 (en) 2011-08-09

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