MA32407B1 - Sels et polymorphes d'un composé tétracycline - Google Patents
Sels et polymorphes d'un composé tétracyclineInfo
- Publication number
- MA32407B1 MA32407B1 MA33447A MA33447A MA32407B1 MA 32407 B1 MA32407 B1 MA 32407B1 MA 33447 A MA33447 A MA 33447A MA 33447 A MA33447 A MA 33447A MA 32407 B1 MA32407 B1 MA 32407B1
- Authority
- MA
- Morocco
- Prior art keywords
- tetracycline compound
- tetracycline
- treatment
- compound
- polymorphic salts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
L'invention concerne des formes cristallines, y compris des sels et polymorphes, d'un composé utile dans le traitement d'états réactifs à un composé tétracycline. Les composés cristallins sont utiles pour le traitement et la prévention d'affections et troubles tels que des infections bactériennes et des néoplasmes, ainsi que d'autres applications connues pour les composés tétracycline en général.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12871208P | 2008-05-23 | 2008-05-23 | |
PCT/US2009/045143 WO2009143509A1 (fr) | 2008-05-23 | 2009-05-26 | Sels et polymorphes d’un composé tétracycline |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32407B1 true MA32407B1 (fr) | 2011-06-01 |
Family
ID=41340587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33447A MA32407B1 (fr) | 2008-05-23 | 2010-12-20 | Sels et polymorphes d'un composé tétracycline |
Country Status (30)
Country | Link |
---|---|
US (4) | US8383610B2 (fr) |
EP (3) | EP2807926B1 (fr) |
JP (6) | JP5727930B2 (fr) |
KR (1) | KR101679362B1 (fr) |
CN (4) | CN108324722A (fr) |
AR (1) | AR075447A1 (fr) |
AU (2) | AU2009248795B2 (fr) |
BR (1) | BRPI0913026B1 (fr) |
CA (2) | CA2724897C (fr) |
CO (1) | CO6300898A2 (fr) |
CY (2) | CY1116436T1 (fr) |
DK (2) | DK2807926T3 (fr) |
EC (1) | ECSP10010704A (fr) |
ES (2) | ES2538364T3 (fr) |
HK (2) | HK1154757A1 (fr) |
HR (2) | HRP20150584T1 (fr) |
HU (1) | HUE053038T2 (fr) |
IL (1) | IL209414A0 (fr) |
LT (1) | LT2807926T (fr) |
MA (1) | MA32407B1 (fr) |
MX (1) | MX2010012622A (fr) |
MY (1) | MY156254A (fr) |
NZ (2) | NZ598154A (fr) |
PL (2) | PL2807926T3 (fr) |
PT (2) | PT2296464E (fr) |
RU (1) | RU2500665C2 (fr) |
SI (2) | SI2296464T1 (fr) |
TW (5) | TW202216656A (fr) |
WO (1) | WO2009143509A1 (fr) |
ZA (1) | ZA201008390B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008134048A2 (fr) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Procédés de synthèse et de purification de composés d'aminoalkyltétracycline |
MX2010009693A (es) | 2008-03-05 | 2010-12-20 | Paratek Pharm Innc | Compuestos de monociclina y metodos de uso de la misma. |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
JP6574572B2 (ja) * | 2011-05-12 | 2019-09-11 | パラテック ファーマシューティカルズ インコーポレイテッド | (4s,4as,5ar,12as)−4−ジメチルアミノ−3,10,12,12a−テトラヒドロキシ−7−[(メトキシ(メチル)アミノ)−メチル]−1,11−ジオキソ−1,4,4a,5,5a,6,11,12a−オクタヒドロ−ナフタセン−2−カルボン酸アミドの結晶塩及びそれを使用する方法 |
PT108223B (pt) | 2015-02-13 | 2018-05-08 | Hovione Farm S A | Novas formas polimórficas de minociclina base e processos para a sua preparação |
TW201705962A (zh) | 2015-03-23 | 2017-02-16 | 生物製藥X公司 | 皮膚用四環素醫藥組成物 |
EP3432891A4 (fr) * | 2016-03-24 | 2019-10-30 | Paratek Pharmaceuticals, Inc. | Méthodes de traitement et de prévention d'une infection à c. difficile |
WO2017192516A1 (fr) * | 2016-05-02 | 2017-11-09 | Paratek Pharmaceuticals, Inc. | Composés de 9-aminométhyl-minocycline et leurs procédés d'utilisation dans le traitement de l'infection des voies urinaires (ivu) |
JP6883593B2 (ja) * | 2016-06-22 | 2021-06-09 | 山東亨利醫藥科技有限責任公司 | 9−アミノメチル基置換のテトラサイクリン系化合物の結晶型及びその製造方法 |
TW202206081A (zh) * | 2016-08-03 | 2022-02-16 | 美商派瑞泰Spv2有限公司 | 9—胺甲基米諾四環素化合物及其用途 |
CA3039027A1 (fr) * | 2016-10-03 | 2018-04-12 | Brivention Pharmaceutical (Shanghai) Inc. | Composition comprenant une combinaison d'un analogue de la trh et d'acide arundique, et sel pharmaceutiquement acceptable de l'acide arundique |
RU2019113715A (ru) | 2016-11-01 | 2020-12-03 | Паратек Фармасьютикалс, Инк. | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
RU2632708C1 (ru) * | 2016-11-14 | 2017-10-09 | Лонг Шенг Фарма Лимитед | Способ получения комбинированного антибактериального препарата |
CN111484424B (zh) * | 2020-04-14 | 2022-10-25 | 成都百特万合医药科技有限公司 | 一种合成奥马环素的方法 |
JP2023530415A (ja) * | 2020-06-11 | 2023-07-18 | パラテック ファーマシューティカルズ,インコーポレイテッド | オマダサイクリンの結晶形態、その合成方法及びその使用方法 |
PT117254A (pt) | 2021-05-26 | 2022-12-30 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
CN113433249B (zh) * | 2021-07-21 | 2023-03-24 | 河北圣雪大成制药有限责任公司 | 一种高效液相色谱法检测米诺环素中间体有关物质的方法 |
CN113929593A (zh) * | 2021-09-02 | 2022-01-14 | 河北圣雪大成唐山制药有限责任公司 | 一种土霉素-2,5-二羟基苯甲酸共晶及其制备方法 |
WO2023047323A1 (fr) * | 2021-09-24 | 2023-03-30 | Glenmark Life Sciences Limited | Procédé de préparation de tosylate d'omadacycline |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
US3019260A (en) * | 1959-05-13 | 1962-01-30 | American Cyanamid Co | Process for the catalytic reduction of 6-hydroxy hydronaphthacenes |
FR1430859A (fr) * | 1960-05-23 | 1966-05-25 | ||
US3165531A (en) * | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
DK122658B (da) * | 1963-06-17 | 1972-03-27 | Novo Terapeutisk Labor As | Fremgangsmåde til udfældning af tetracyclinbase i krystallinsk form. |
US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
NL6607516A (fr) | 1966-05-31 | 1967-12-01 | ||
DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
CA999855A (en) * | 1972-09-18 | 1976-11-16 | Societa' Farmaceutici Italia S.P.A. | Process for the preparation of tetracyclines derivatives in the 7 position |
US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
JP3016587B2 (ja) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
DE4031168A1 (de) | 1990-10-03 | 1992-04-16 | Degussa | Keramischer werkstoff zum verblenden von metallischem zahnersatz |
US5770588A (en) * | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
SG52361A1 (en) | 1991-10-04 | 1998-09-28 | American Cyanamid Co | Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
EP0599397B1 (fr) | 1992-11-17 | 1996-08-28 | The Research Foundation Of State University Of New York | Tétracyclines comprenant les tétracyclines modifiées chimiquement afin d'être non-antimicrobiennes inhibent la réticulation excessive du collagène lors du diabète |
US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
WO1995022529A1 (fr) | 1994-02-17 | 1995-08-24 | Pfizer Inc. | Derives de 9-(amino-substitues)-alpha-6-deoxy-5-oxy tetracycline, leur preparation et leur utilisation comme antibiotiques |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
US5773430A (en) * | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
US6277067B1 (en) | 1997-04-04 | 2001-08-21 | Kerry L. Blair | Method and portable colposcope useful in cervical cancer detection |
US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
EP1137410B1 (fr) | 1998-11-18 | 2006-08-16 | Collagenex Pharmaceuticals, Inc. | Nouveaux derives de 4-dedimethyl aminotetracycline |
DE19938198A1 (de) * | 1999-08-12 | 2001-03-01 | Deutsche Telekom Ag | Verfahren zum Etablieren eines gemeinsamen Schlüssels für eine Gruppe von mindestens drei Teilnehmern |
US6231894B1 (en) * | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
US7231517B1 (en) * | 2000-03-03 | 2007-06-12 | Novell, Inc. | Apparatus and method for automatically authenticating a network client |
ATE336481T1 (de) * | 2000-07-07 | 2006-09-15 | Tufts College | 9-substituierte minocyclinverbindungen |
MXPA03000056A (es) * | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de tetraciclina sustituidos en posicion 7. |
CZ20032780A3 (cs) | 2001-03-13 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | 7,9- Substituované tetracyklinové sloučeniny |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2003004009A1 (fr) * | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Formulation a compression directe de medicaments faiblement compressibles tels que le chlorhydrate de metformine |
CN102531948A (zh) * | 2002-03-08 | 2012-07-04 | 帕拉特克药品公司 | 氨基-甲基取代的四环素类化合物 |
JP4099039B2 (ja) * | 2002-11-15 | 2008-06-11 | 松下電器産業株式会社 | プログラム更新方法 |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
JP4712325B2 (ja) * | 2003-09-12 | 2011-06-29 | 株式会社リコー | 通信装置、通信システム、通信方法及びプログラム |
US8015399B2 (en) * | 2003-09-30 | 2011-09-06 | Ricoh Company, Ltd. | Communication apparatus, communication system, certificate transmission method and program |
JP4621200B2 (ja) * | 2004-04-15 | 2011-01-26 | パナソニック株式会社 | 通信装置、通信システム及び認証方法 |
AR057649A1 (es) * | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
CA2639406A1 (fr) * | 2006-01-24 | 2007-08-02 | Paratek Pharmaceuticals, Inc. | Procede permettant d'accroitre la biodisponibilite orale de tetracyclines |
CA2649075A1 (fr) * | 2006-04-24 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Formes cristallines de tigecycline et leurs procedes de preparation |
CN101134733A (zh) * | 2007-09-24 | 2008-03-05 | 合肥信风科技开发有限公司 | 一种替加环素的物质形态及其制备方法 |
MX2010009693A (es) * | 2008-03-05 | 2010-12-20 | Paratek Pharm Innc | Compuestos de monociclina y metodos de uso de la misma. |
PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
-
2009
- 2009-05-25 TW TW110123796A patent/TW202216656A/zh unknown
- 2009-05-25 TW TW108126026A patent/TW202021946A/zh unknown
- 2009-05-25 TW TW098117308A patent/TWI585071B/zh active
- 2009-05-25 TW TW111139004A patent/TW202332671A/zh unknown
- 2009-05-25 TW TW106103523A patent/TWI680117B/zh active
- 2009-05-26 CN CN201810151302.7A patent/CN108324722A/zh active Pending
- 2009-05-26 ES ES09751737.9T patent/ES2538364T3/es active Active
- 2009-05-26 PT PT97517379T patent/PT2296464E/pt unknown
- 2009-05-26 CA CA2724897A patent/CA2724897C/fr active Active
- 2009-05-26 CN CN201510265009.XA patent/CN104844472B/zh active Active
- 2009-05-26 AR ARP090101875A patent/AR075447A1/es not_active Application Discontinuation
- 2009-05-26 SI SI200931200T patent/SI2296464T1/sl unknown
- 2009-05-26 HU HUE14156670A patent/HUE053038T2/hu unknown
- 2009-05-26 SI SI200932103T patent/SI2807926T1/sl unknown
- 2009-05-26 DK DK14156670.3T patent/DK2807926T3/da active
- 2009-05-26 MX MX2010012622A patent/MX2010012622A/es active IP Right Grant
- 2009-05-26 EP EP14156670.3A patent/EP2807926B1/fr active Active
- 2009-05-26 PL PL14156670T patent/PL2807926T3/pl unknown
- 2009-05-26 CN CN201510647227.XA patent/CN105348138A/zh active Pending
- 2009-05-26 AU AU2009248795A patent/AU2009248795B2/en active Active
- 2009-05-26 WO PCT/US2009/045143 patent/WO2009143509A1/fr active Application Filing
- 2009-05-26 MY MYPI2010005445A patent/MY156254A/en unknown
- 2009-05-26 RU RU2010152758/04A patent/RU2500665C2/ru active
- 2009-05-26 PL PL09751737T patent/PL2296464T3/pl unknown
- 2009-05-26 CA CA2987354A patent/CA2987354A1/fr not_active Abandoned
- 2009-05-26 CN CN200980129398.6A patent/CN102105058B/zh active Active
- 2009-05-26 NZ NZ598154A patent/NZ598154A/xx unknown
- 2009-05-26 BR BRPI0913026-8A patent/BRPI0913026B1/pt active IP Right Grant
- 2009-05-26 EP EP09751737.9A patent/EP2296464B1/fr active Active
- 2009-05-26 DK DK09751737.9T patent/DK2296464T3/en active
- 2009-05-26 JP JP2011510742A patent/JP5727930B2/ja active Active
- 2009-05-26 NZ NZ589574A patent/NZ589574A/en unknown
- 2009-05-26 US US12/471,758 patent/US8383610B2/en active Active
- 2009-05-26 PT PT141566703T patent/PT2807926T/pt unknown
- 2009-05-26 KR KR1020107028820A patent/KR101679362B1/ko active IP Right Grant
- 2009-05-26 EP EP20200158.2A patent/EP3827817A1/fr active Pending
- 2009-05-26 ES ES14156670T patent/ES2842204T3/es active Active
- 2009-05-26 LT LTEP14156670.3T patent/LT2807926T/lt unknown
-
2010
- 2010-11-18 IL IL209414A patent/IL209414A0/en active IP Right Grant
- 2010-11-23 ZA ZA2010/08390A patent/ZA201008390B/en unknown
- 2010-12-20 MA MA33447A patent/MA32407B1/fr unknown
- 2010-12-22 CO CO10160851A patent/CO6300898A2/es not_active Application Discontinuation
- 2010-12-22 EC EC2010010704A patent/ECSP10010704A/es unknown
-
2011
- 2011-08-30 HK HK11109171.9A patent/HK1154757A1/xx unknown
- 2011-08-30 HK HK15105134.9A patent/HK1204526A1/xx unknown
-
2013
- 2013-01-24 US US13/749,101 patent/US9227921B2/en active Active
-
2015
- 2015-04-03 JP JP2015076659A patent/JP6129235B2/ja active Active
- 2015-06-02 HR HRP20150584TT patent/HRP20150584T1/hr unknown
- 2015-06-04 CY CY20151100497T patent/CY1116436T1/el unknown
- 2015-12-08 US US14/962,326 patent/US20160324879A1/en not_active Abandoned
-
2016
- 2016-11-23 AU AU2016262682A patent/AU2016262682B2/en active Active
-
2017
- 2017-04-11 JP JP2017077920A patent/JP2017149750A/ja active Pending
- 2017-09-21 US US15/711,502 patent/US20180104262A1/en not_active Abandoned
-
2018
- 2018-12-21 JP JP2018239471A patent/JP2019052184A/ja active Pending
-
2020
- 2020-10-23 JP JP2020177908A patent/JP2021011498A/ja active Pending
- 2020-12-29 CY CY20201101224T patent/CY1123705T1/el unknown
- 2020-12-31 HR HRP20202081TT patent/HRP20202081T1/hr unknown
-
2022
- 2022-10-21 JP JP2022169225A patent/JP2022189916A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA32407B1 (fr) | Sels et polymorphes d'un composé tétracycline | |
MA31373B1 (fr) | Composes amino-heterocycliques | |
MA32104B1 (fr) | Dérivés d'oxime en tant qu'inhibiteurs de hsp90 | |
ATE482947T1 (de) | Neues salz und polymorph des dpp-iv-hemmers | |
UY31083A1 (es) | Derivados de sulfoximinas para la inhibicion de b-secretasa | |
UY29919A1 (es) | Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones | |
MA37383A1 (fr) | Compose heterobicycliques comme inhibiteurs de la beta lactamase | |
MA33636B1 (fr) | Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine | |
MA30532B1 (fr) | Sulfonamides tricycliques condenses inhibiteurs de gamma-secretase | |
MA34234B1 (fr) | Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation | |
MA32904B1 (fr) | Composes de purine | |
MA29240B1 (fr) | Derives d'indole pour le traitement d'infections virales | |
MA32468B1 (fr) | Derives de thiophene ou de thiazole et leur utilisation comme inhibiteurs de pi3k | |
MA30781B1 (fr) | Inhibiteur de kinase | |
MX2009012163A (es) | Hetarilanilinas como moduladores para beta-amiloide. | |
ECSP055910A (es) | Nuevos acidos carboxilicos y sus esteres, medicamentos que contienen estos compuestos y procedimientos para su preparacion | |
MA37886A1 (fr) | Nouvelles pyridinones bicycliques | |
MA35285B1 (fr) | Indazoles | |
MA33358B1 (fr) | Arylpyridine en tant qu'inhibiteurs de l'aldostérone synthase | |
MA31400B1 (fr) | Composes organiques | |
MA35128B1 (fr) | Nouveaux dérivés d'imidazole utiles pour le traitement de l'arthrite | |
MA32231B1 (fr) | Composés organiques | |
ECSP088625A (es) | Compuestos para el tratamiento de trastornos inflamatorios | |
MA31979B1 (fr) | (cyclopropylphenyl) phenyloxamides, leur procede de production et leur utilisation comme medicament | |
RS52823B (en) | NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES |