MA39777B1 - Composes organiques de la famille des monobactams pour le traitement d'infections bactériennes - Google Patents
Composes organiques de la famille des monobactams pour le traitement d'infections bactériennesInfo
- Publication number
- MA39777B1 MA39777B1 MA39777A MA39777A MA39777B1 MA 39777 B1 MA39777 B1 MA 39777B1 MA 39777 A MA39777 A MA 39777A MA 39777 A MA39777 A MA 39777A MA 39777 B1 MA39777 B1 MA 39777B1
- Authority
- MA
- Morocco
- Prior art keywords
- monobactam
- family
- treatment
- organic compounds
- bacterial infections
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 title 1
- 229960003644 aztreonam Drugs 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 150000002894 organic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cette invention se rapporte d'une manière générale à des composés antibactériens de formule i, tels que décrits dans l'invention, et des formulations et des sels pharmaceutiquement acceptables de ceux-ci. Dans certains aspects, l'invention se rapporte à des procédés d'utilisation de tels composés pour traiter des infections telles que celles provoquées par des bactéries gram négatif.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461969735P | 2014-03-24 | 2014-03-24 | |
US201462088304P | 2014-12-05 | 2014-12-05 | |
PCT/US2015/022011 WO2015148379A1 (fr) | 2014-03-24 | 2015-03-23 | Composés organiques monobactam pour le traitement d'infections bactériennes |
EP15714147.4A EP3122745B1 (fr) | 2014-03-24 | 2015-03-23 | Composes organiques de la famille des monobactams pour le traitement d'infections bactériennes |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39777A MA39777A (fr) | 2017-02-01 |
MA39777B1 true MA39777B1 (fr) | 2019-03-29 |
Family
ID=52808201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39777A MA39777B1 (fr) | 2014-03-24 | 2015-03-23 | Composes organiques de la famille des monobactams pour le traitement d'infections bactériennes |
Country Status (36)
Country | Link |
---|---|
US (4) | US9174978B2 (fr) |
EP (2) | EP3122745B1 (fr) |
JP (1) | JP6153674B2 (fr) |
KR (1) | KR101733441B1 (fr) |
CN (1) | CN106164072B (fr) |
AP (1) | AP2016009374A0 (fr) |
AU (1) | AU2015236369B2 (fr) |
BR (1) | BR112016020333B1 (fr) |
CA (1) | CA2939254C (fr) |
CL (1) | CL2016002285A1 (fr) |
CU (1) | CU24441B1 (fr) |
CY (1) | CY1121701T1 (fr) |
DK (2) | DK3122745T3 (fr) |
EA (1) | EA030850B1 (fr) |
EC (1) | ECSP16073620A (fr) |
ES (2) | ES2862203T3 (fr) |
GT (1) | GT201600183A (fr) |
HR (1) | HRP20190501T1 (fr) |
HU (1) | HUE042134T2 (fr) |
IL (1) | IL247259B (fr) |
LT (1) | LT3122745T (fr) |
MA (1) | MA39777B1 (fr) |
MX (1) | MX2016011822A (fr) |
MY (1) | MY179292A (fr) |
PE (1) | PE20161371A1 (fr) |
PH (1) | PH12016501577A1 (fr) |
PL (1) | PL3122745T3 (fr) |
PT (1) | PT3122745T (fr) |
RS (1) | RS58509B1 (fr) |
SG (1) | SG11201606711UA (fr) |
SI (1) | SI3122745T1 (fr) |
SV (1) | SV2016005274A (fr) |
TW (1) | TWI714525B (fr) |
UA (1) | UA121383C2 (fr) |
WO (1) | WO2015148379A1 (fr) |
ZA (1) | ZA201605565B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3353175T3 (da) * | 2015-09-23 | 2020-09-14 | Novartis Ag | Salte og faste former af et monobactam-antibiotikum |
WO2017081615A1 (fr) | 2015-11-09 | 2017-05-18 | Wockhardt Limited | 7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1] octane contenant des composés et leur utilisation dans le traitement d'infections bactériennes |
JP7184646B2 (ja) | 2015-12-15 | 2022-12-06 | メルク・シャープ・アンド・ドーム・エルエルシー | ビアリールモノバクタム化合物および細菌感染治療のためのそれの使用方法 |
AU2017228870B2 (en) | 2016-03-07 | 2021-02-18 | Merck Sharp & Dohme Llc | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
IL269390B (en) | 2017-03-20 | 2022-08-01 | Broad Inst Inc | Preparations and methods for the treatment of parasitic diseases |
WO2019026004A2 (fr) * | 2017-08-02 | 2019-02-07 | Novartis Ag | Processus chimique de préparation d'antibiotique monobactame et de ses intermédiaires |
WO2019058346A1 (fr) * | 2017-09-22 | 2019-03-28 | Novartis Ag | Administration de monobactame en association avec un agent antibiotique pour le traitement d'une infection intra-abdominale compliquée |
BR112020006381A8 (pt) | 2017-10-02 | 2023-04-11 | Merck Sharp & Dohme | Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
CA3077474A1 (fr) * | 2017-10-02 | 2019-04-11 | Arixa Pharmaceuticals, Inc. | Derives d'aztreonam et utilisations associees |
WO2019092180A1 (fr) * | 2017-11-10 | 2019-05-16 | Novartis Ag | Administration de monobactame pour le traitement d'une infection urinaire |
JP7280273B2 (ja) | 2018-01-29 | 2023-05-23 | メッドシャイン ディスカバリー インコーポレイテッド | 細菌感染を治療するための単環β-ラクタム化合物 |
KR102017784B1 (ko) * | 2018-04-11 | 2019-09-03 | 전북대학교산학협력단 | 민감성 및 선택성을 개선한 캠필로박터 검출용 배지 조성물 및 이를 이용한 캠필로박터 검출방법 |
KR102017785B1 (ko) * | 2018-05-17 | 2019-09-03 | 전북대학교산학협력단 | 민감성 및 선택성을 개선한 캠필로박터 선택증균용 배지 조성물 및 이를 이용한 캠필로박터 검출방법 |
US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
CN112771040B (zh) | 2018-11-13 | 2022-10-18 | 南京圣和药业股份有限公司 | 单环内酰胺化合物及其应用 |
JP7179185B2 (ja) * | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β-ラクタム化合物の使用 |
WO2021098840A1 (fr) | 2019-11-22 | 2021-05-27 | 南京明德新药研发有限公司 | ANTIBIOTIQUES DE β-LACTAME MONOCYCLIQUES SUBSTITUÉS PAR UN NOYAU DE SULFONYLURÉE |
CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
WO2021121387A1 (fr) | 2019-12-19 | 2021-06-24 | 南京明德新药研发有限公司 | Application d'un composé dans la préparation de médicament |
EP3838266A1 (fr) | 2019-12-20 | 2021-06-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Production microfluidique de vésicules unilamellaires géantes biofonctionnalisées pour l'administration intracellulaire ciblée de molécules cargo |
CN113754651B (zh) | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
WO2022011626A1 (fr) * | 2020-07-16 | 2022-01-20 | Ningxia Academy Of Agriculture And Forestry Sciences | Nouveaux composés monobactam, leur préparation et leur utilisation en tant qu'agents antibactériens |
WO2022185241A1 (fr) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Procédé de fabrication d'un antibiotique monobactame |
WO2022185240A1 (fr) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Formulation d'un antibiotique monobactame |
EP4433476A1 (fr) | 2021-11-18 | 2024-09-25 | Merck Sharp & Dohme LLC | Antibiotiques monobactams de chromane amidine |
CN115304594B (zh) | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
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