MX2018010878A - Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. - Google Patents

Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas.

Info

Publication number
MX2018010878A
MX2018010878A MX2018010878A MX2018010878A MX2018010878A MX 2018010878 A MX2018010878 A MX 2018010878A MX 2018010878 A MX2018010878 A MX 2018010878A MX 2018010878 A MX2018010878 A MX 2018010878A MX 2018010878 A MX2018010878 A MX 2018010878A
Authority
MX
Mexico
Prior art keywords
bicyclic aryl
methods
treatment
bacterial infections
pharmaceutically acceptable
Prior art date
Application number
MX2018010878A
Other languages
English (en)
Inventor
Liu Weiguo
Sun Wanying
Tang Haifeng
Xiang DING Fa-
Huang Xianhai
Wang Hongwu
Guo Yan
Keh Dejesus Reynalda
Jian Jinlong
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2018010878A publication Critical patent/MX2018010878A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a compuestos de aril-monobactam bicíclicos de fórmula (I): (ver Fórmula) y sales farmacéuticamente aceptables de los mismos, en donde A1, L, M, W, X, Y, Z, RX y RZ son como se define en la presente. La presente invención también se refiere a composiciones que comprenden un compuesto de aril-monobactam bicíclico de la invención o una sal farmacéuticamente aceptable del mismo y un vehículo farmacéuticamente aceptable. La invención se refiere además a métodos de tratamiento de una infección bacteriana, que comprenden administrarle al paciente una cantidad terapéuticamente eficaz de un compuesto de la invención, ya sea solo o en combinación con una cantidad terapéuticamente eficaz de uno o más compuestos inhibidores de beta-lactamasa.
MX2018010878A 2016-03-07 2017-03-02 Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. MX2018010878A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662304447P 2016-03-07 2016-03-07
PCT/US2017/020303 WO2017155765A1 (en) 2016-03-07 2017-03-02 Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
MX2018010878A true MX2018010878A (es) 2018-11-09

Family

ID=59789685

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010878A MX2018010878A (es) 2016-03-07 2017-03-02 Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas.

Country Status (12)

Country Link
US (1) US10407421B2 (es)
EP (1) EP3426248B1 (es)
JP (1) JP7034929B2 (es)
KR (1) KR102408800B1 (es)
CN (1) CN108778273B (es)
AU (1) AU2017228870B2 (es)
BR (1) BR112018067930B1 (es)
CA (1) CA3016341A1 (es)
MA (1) MA43811A (es)
MX (1) MX2018010878A (es)
RU (1) RU2733402C2 (es)
WO (1) WO2017155765A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018067930B1 (pt) 2016-03-07 2024-02-15 Merck Sharp & Dohme Llc Composto, sal de ácido trifluoroacético, composição farmacêutica, e, uso de um composto
PE20200008A1 (es) 2017-03-30 2020-01-06 Hoffmann La Roche Isoquinolinas como inhibidores de hpk1
EA202090604A1 (ru) * 2017-10-02 2020-10-15 Мерк Шарп энд Доум Корп. Хроманмонобактамовые соединения для лечения бактериальных инфекций
CN111511737B (zh) * 2018-01-29 2022-10-18 南京明德新药研发有限公司 用于治疗细菌感染的单环β-内酰胺化合物
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
JP2022507470A (ja) * 2018-11-13 2022-01-18 南京聖和薬業股▲ふん▼有限公司 モノバクタム化合物及びその使用
WO2020125670A1 (zh) * 2018-12-18 2020-06-25 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用
CN110963967B (zh) * 2019-11-25 2021-02-12 武汉智顿科技发展有限公司 一种2-甲基-4-氨基喹啉的制备方法
CN111018777B (zh) * 2019-11-25 2021-02-12 武汉智顿科技发展有限公司 一种地喹氯铵的制备方法
CN111303144B (zh) * 2019-12-13 2020-11-27 苏州信诺维医药科技有限公司 一种治疗细菌感染的化合物
WO2021121387A1 (zh) * 2019-12-19 2021-06-24 南京明德新药研发有限公司 化合物在制药中的应用
WO2023082055A1 (zh) * 2021-11-09 2023-05-19 中国医学科学院医药生物技术研究所 包含β-内酰胺类化合物的药物组合物及其用途

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4684722A (en) 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
US5250691A (en) * 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
MY127641A (en) 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
RU2269525C2 (ru) * 2000-08-10 2006-02-10 Бритиш Биотех Фармасьютикалс Лимитед Антибактериальные агенты
PT2308874E (pt) 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
ES2542431T3 (es) 2010-11-29 2015-08-05 Pfizer Inc Monobactamas
UY34585A (es) * 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
US20140275007A1 (en) 2013-03-14 2014-09-18 Rempex Pharmaceuticals, Inc. Oxamazin antibiotics
AU2015236369B2 (en) 2014-03-24 2017-02-16 Novartis Ag Monobactam organic compounds for the treatment of bacterial infections
BR112018067930B1 (pt) 2016-03-07 2024-02-15 Merck Sharp & Dohme Llc Composto, sal de ácido trifluoroacético, composição farmacêutica, e, uso de um composto

Also Published As

Publication number Publication date
EP3426248A1 (en) 2019-01-16
JP2019507768A (ja) 2019-03-22
RU2018134948A3 (es) 2020-04-08
AU2017228870A1 (en) 2018-09-06
US20190071436A1 (en) 2019-03-07
EP3426248B1 (en) 2023-11-15
EP3426248A4 (en) 2019-07-10
MA43811A (fr) 2018-11-28
CN108778273B (zh) 2022-06-17
KR102408800B1 (ko) 2022-06-13
BR112018067930B1 (pt) 2024-02-15
KR20180121948A (ko) 2018-11-09
BR112018067930A2 (pt) 2019-01-22
RU2733402C2 (ru) 2020-10-01
RU2018134948A (ru) 2020-04-08
WO2017155765A1 (en) 2017-09-14
CA3016341A1 (en) 2017-09-14
AU2017228870B2 (en) 2021-02-18
CN108778273A (zh) 2018-11-09
BR112018067930A8 (pt) 2023-04-11
US10407421B2 (en) 2019-09-10
JP7034929B2 (ja) 2022-03-14

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