EA201500544A1 - НОВЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ АГЕНТОВ И ИНГИБИТОРОВ β-ЛАКТАМАЗ - Google Patents

НОВЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ АГЕНТОВ И ИНГИБИТОРОВ β-ЛАКТАМАЗ

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Publication number
EA201500544A1
EA201500544A1 EA201500544A EA201500544A EA201500544A1 EA 201500544 A1 EA201500544 A1 EA 201500544A1 EA 201500544 A EA201500544 A EA 201500544A EA 201500544 A EA201500544 A EA 201500544A EA 201500544 A1 EA201500544 A1 EA 201500544A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lactamaz
inhibitors
application
antibacterial agents
bicyclic compounds
Prior art date
Application number
EA201500544A
Other languages
English (en)
Other versions
EA028633B1 (ru
Inventor
Самарендра Н. Маити
Даи Нгуен
Джехангир Кан
Ронг Линг
Original Assignee
Федора Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федора Фармасьютикалз Инк. filed Critical Федора Фармасьютикалз Инк.
Publication of EA201500544A1 publication Critical patent/EA201500544A1/ru
Publication of EA028633B1 publication Critical patent/EA028633B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Соединение формулы (I)где М представляет собой водород или фармацевтически приемлемый солеобразующий катион; Y представляет собой ORили NRR, и R, R, Rи М являются такими, как здесь определено. Также, способы лечения бактериальной инфекции, фармацевтические композиции, молекулярные комплексы и способы получения соединений.
EA201500544A 2012-12-11 2012-12-11 БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ АГЕНТОВ И ИНГИБИТОРОВ β-ЛАКТАМАЗ EA028633B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/002675 WO2014091268A1 (en) 2012-12-11 2012-12-11 NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Publications (2)

Publication Number Publication Date
EA201500544A1 true EA201500544A1 (ru) 2015-12-30
EA028633B1 EA028633B1 (ru) 2017-12-29

Family

ID=50933808

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500544A EA028633B1 (ru) 2012-12-11 2012-12-11 БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТИБАКТЕРИАЛЬНЫХ АГЕНТОВ И ИНГИБИТОРОВ β-ЛАКТАМАЗ

Country Status (18)

Country Link
EP (1) EP2931723B1 (ru)
JP (1) JP2016503000A (ru)
KR (1) KR20150093809A (ru)
CN (1) CN105873930B (ru)
AU (1) AU2012396338B2 (ru)
BR (1) BR112015013450A8 (ru)
CA (1) CA2893804C (ru)
CR (1) CR20150359A (ru)
EA (1) EA028633B1 (ru)
EC (1) ECSP15029636A (ru)
ES (1) ES2817785T3 (ru)
IL (1) IL239116B (ru)
MA (1) MA38227B1 (ru)
MX (1) MX2015007406A (ru)
PH (1) PH12015501303A1 (ru)
SG (1) SG11201504540TA (ru)
UA (1) UA111925C2 (ru)
WO (1) WO2014091268A1 (ru)

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CN107383034A (zh) * 2017-06-29 2017-11-24 上海药明康德新药开发有限公司 外消旋‑5‑(叔丁氧羰基)‑八氢呋喃并[3,2‑c]吡啶‑3a‑羧酸的合成方法
MA49623A (fr) 2017-07-21 2021-03-17 Antabio Sas Composés chimiques
KR20200091395A (ko) * 2017-09-27 2020-07-30 페도라 파마슈티칼스 인코포레이티드 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법
CN111417633B (zh) * 2017-12-01 2022-05-06 齐鲁制药有限公司 一种β-内酰胺酶抑制剂的晶型及其制备方法
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Also Published As

Publication number Publication date
EP2931723A4 (en) 2016-06-01
KR20150093809A (ko) 2015-08-18
CA2893804A1 (en) 2014-06-19
MX2015007406A (es) 2015-12-03
PH12015501303A1 (en) 2015-08-24
CR20150359A (es) 2015-08-20
JP2016503000A (ja) 2016-02-01
UA111925C2 (uk) 2016-06-24
EP2931723B1 (en) 2020-08-26
ECSP15029636A (es) 2016-01-29
EA028633B1 (ru) 2017-12-29
IL239116A0 (en) 2015-07-30
BR112015013450A8 (pt) 2019-10-08
BR112015013450A2 (pt) 2017-07-11
IL239116B (en) 2019-05-30
EP2931723A1 (en) 2015-10-21
MA38227A1 (fr) 2016-12-30
ES2817785T3 (es) 2021-04-08
AU2012396338B2 (en) 2017-09-28
CA2893804C (en) 2021-05-18
WO2014091268A1 (en) 2014-06-19
CN105873930A (zh) 2016-08-17
CN105873930B (zh) 2019-02-19
AU2012396338A1 (en) 2015-07-16
SG11201504540TA (en) 2015-07-30
MA38227B1 (fr) 2017-10-31
NZ709355A (en) 2017-09-29

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