FR2936951B1 - Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments - Google Patents

Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments

Info

Publication number
FR2936951B1
FR2936951B1 FR0805618A FR0805618A FR2936951B1 FR 2936951 B1 FR2936951 B1 FR 2936951B1 FR 0805618 A FR0805618 A FR 0805618A FR 0805618 A FR0805618 A FR 0805618A FR 2936951 B1 FR2936951 B1 FR 2936951B1
Authority
FR
France
Prior art keywords
antibacterial
compounds
medicaments
novel combinations
heterocyclic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0805618A
Other languages
English (en)
Other versions
FR2936951A1 (fr
Inventor
Premavathy Levasseur
John Lee Pace
Kenneth Coleman
John Lowther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novexel SA
Original Assignee
Novexel SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novexel SA filed Critical Novexel SA
Priority to FR0805618A priority Critical patent/FR2936951B1/fr
Priority to US12/535,865 priority patent/US20100092443A1/en
Priority to BRPI0919812A priority patent/BRPI0919812A8/pt
Priority to EA201170532A priority patent/EA201170532A1/ru
Priority to CN200980146340.2A priority patent/CN102216301B/zh
Priority to JP2011530584A priority patent/JP2012505196A/ja
Priority to PE2011000865A priority patent/PE20110392A1/es
Priority to NZ592165A priority patent/NZ592165A/xx
Priority to EP09786281A priority patent/EP2344500A1/fr
Priority to KR1020117010169A priority patent/KR20110067148A/ko
Priority to CA2740035A priority patent/CA2740035A1/fr
Priority to PCT/IB2009/006992 priority patent/WO2010041112A1/fr
Priority to AU2009302153A priority patent/AU2009302153A1/en
Priority to MX2011003812A priority patent/MX2011003812A/es
Priority to ARP090103834A priority patent/AR073771A1/es
Priority to TW098133951A priority patent/TW201026697A/zh
Priority to UY0001032168A priority patent/UY32168A/es
Priority to PA20098845401A priority patent/PA8845401A1/es
Publication of FR2936951A1 publication Critical patent/FR2936951A1/fr
Application granted granted Critical
Publication of FR2936951B1 publication Critical patent/FR2936951B1/fr
Priority to ZA2011/02498A priority patent/ZA201102498B/en
Priority to IL212180A priority patent/IL212180A0/en
Priority to CL2011000783A priority patent/CL2011000783A1/es
Priority to CO11043791A priority patent/CO6361930A2/es
Priority to EC2011010973A priority patent/ECSP11010973A/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
FR0805618A 2008-10-10 2008-10-10 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments Expired - Fee Related FR2936951B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR0805618A FR2936951B1 (fr) 2008-10-10 2008-10-10 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
US12/535,865 US20100092443A1 (en) 2008-10-10 2009-08-05 Novel combinations of nitrogenated heterocyclic antibacterial compounds with other antibacterial compounds and the use of same as drugs
MX2011003812A MX2011003812A (es) 2008-10-10 2009-09-29 Nuevas combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentos.
CN200980146340.2A CN102216301B (zh) 2008-10-10 2009-09-29 含氮杂环抗菌化合物与其它抗菌化合物的新型组合及该组合作为药剂的用途
JP2011530584A JP2012505196A (ja) 2008-10-10 2009-09-29 含窒素複素環抗菌化合物と他の抗菌化合物との新規な配合物と、該化合物の薬物としての使用
PE2011000865A PE20110392A1 (es) 2008-10-10 2009-09-29 Combinacion farmaceutica que comprende heterociclicos nitrogenados antibacterianos con otro antibacteriano
NZ592165A NZ592165A (en) 2008-10-10 2009-09-29 Novel combinations of antibacterial nitrogenous heterocyclic compounds with other antibacterial compounds, and use thereof as drugs
EP09786281A EP2344500A1 (fr) 2008-10-10 2009-09-29 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
KR1020117010169A KR20110067148A (ko) 2008-10-10 2009-09-29 다른 항균 화합물이 부가된 질화 헤테로사이클릭 항균 화합물의 신규한 배합 및 약품으로서의 이들의 용도
CA2740035A CA2740035A1 (fr) 2008-10-10 2009-09-29 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
PCT/IB2009/006992 WO2010041112A1 (fr) 2008-10-10 2009-09-29 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
AU2009302153A AU2009302153A1 (en) 2008-10-10 2009-09-29 Novel combinations of antibacterial nitrogenous heterocyclic compounds with other antibacterial compounds, and use thereof as drugs
BRPI0919812A BRPI0919812A8 (pt) 2008-10-10 2009-09-29 Combinações de compostos antibacterianos heterocíclicos hirdrogenados com outros compostos antibacterianos e o uso dos mesmos como medicamentos
EA201170532A EA201170532A1 (ru) 2008-10-10 2009-09-29 Новые комбинации антибактериальных азотсодержащих гетероциклических соединений с другими антибактериальными соединениями и их применение в качестве лекарственных средств
ARP090103834A AR073771A1 (es) 2008-10-10 2009-10-05 Combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentos
TW098133951A TW201026697A (en) 2008-10-10 2009-10-07 Novel combinations of nitrogenated heterocyclic antibacterial compounds with other antibacterial compounds and the use of same as drugs
UY0001032168A UY32168A (es) 2008-10-10 2009-10-08 Nuevas composiciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilización como medicamentos
PA20098845401A PA8845401A1 (es) 2008-10-10 2009-10-09 Nuevas combinaciones de compuestos heterocíclicos nitrogenados antibacterianos con otros compuestos antibacterianos .....
ZA2011/02498A ZA201102498B (en) 2008-10-10 2011-04-05 Novel combinations of antibacterial nitrogenous heterocyclic compounds with other antibacterial compounds,and use thereof as drugs
IL212180A IL212180A0 (en) 2008-10-10 2011-04-06 Novel combinations of antibacterial nitrogenous heterocyclic compounds with other antibacterial compounds, and use thereof as drugs
CL2011000783A CL2011000783A1 (es) 2008-10-10 2011-04-08 Combinacion sinergica de un compuesto heterociclico nitrogenado de formula i antibacteriano con otro compuesto antibacteriano; medicamento; composicion farmaceutica; util para tratar infecciones bacterianas.
CO11043791A CO6361930A2 (es) 2008-10-10 2011-04-08 Nuevas combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentos
EC2011010973A ECSP11010973A (es) 2008-10-10 2011-04-11 Nuevas combinaciones de compuestos heterocíclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilización como medicamentos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0805618A FR2936951B1 (fr) 2008-10-10 2008-10-10 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
FR2936951A1 FR2936951A1 (fr) 2010-04-16
FR2936951B1 true FR2936951B1 (fr) 2010-12-03

Family

ID=40591054

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0805618A Expired - Fee Related FR2936951B1 (fr) 2008-10-10 2008-10-10 Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments

Country Status (23)

Country Link
US (1) US20100092443A1 (fr)
EP (1) EP2344500A1 (fr)
JP (1) JP2012505196A (fr)
KR (1) KR20110067148A (fr)
CN (1) CN102216301B (fr)
AR (1) AR073771A1 (fr)
AU (1) AU2009302153A1 (fr)
BR (1) BRPI0919812A8 (fr)
CA (1) CA2740035A1 (fr)
CL (1) CL2011000783A1 (fr)
CO (1) CO6361930A2 (fr)
EA (1) EA201170532A1 (fr)
EC (1) ECSP11010973A (fr)
FR (1) FR2936951B1 (fr)
IL (1) IL212180A0 (fr)
MX (1) MX2011003812A (fr)
NZ (1) NZ592165A (fr)
PA (1) PA8845401A1 (fr)
PE (1) PE20110392A1 (fr)
TW (1) TW201026697A (fr)
UY (1) UY32168A (fr)
WO (1) WO2010041112A1 (fr)
ZA (1) ZA201102498B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG190877A1 (en) 2010-11-25 2013-07-31 Allecra Therapeutics Gmbh Compounds and their use
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
GB201305277D0 (en) * 2013-03-22 2013-05-01 Helperby Therapeutics Ltd Novel combination and use
JP6411482B2 (ja) 2013-10-11 2018-10-24 ウォックハート リミテッド 窒素含有化合物およびその使用
JP6764862B2 (ja) * 2014-11-17 2020-10-07 エンタシス・セラピューティックス・リミテッド 耐性細菌感染症の治療のための併用療法
IL289686B2 (en) 2016-09-16 2023-03-01 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
PL3630111T3 (pl) 2017-05-08 2022-05-23 Entasis Therapeutics, Inc. Związki i sposoby leczenia zakażeń bakteryjnych
GB202213753D0 (en) * 2022-09-20 2022-11-02 Helperby Therapeutics Ltd Antimicrobial combinations

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
ID24703A (id) * 1997-09-15 2000-08-03 Procter & Gamble Kuinolon antimikroba, komposisi dan penggunaannya
DK1280809T3 (da) * 2000-04-12 2005-11-07 Pharma Mar Sa Antitumorecteinascidinderivater
AU2002230891B2 (en) * 2000-12-14 2005-04-07 The Procter & Gamble Company Antimicrobial quinolones
NZ525570A (en) * 2000-12-14 2005-04-29 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7232833B2 (en) * 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
WO2005004799A2 (fr) * 2003-06-10 2005-01-20 Fulcrum Pharmaceuticals, Inc. Inhibiteurs de $g(b)-lactamases et methodes d'utilisation de ces inhibiteurs
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
CN101129383B (zh) * 2006-08-25 2014-04-02 天津和美生物技术有限公司 含氨基糖苷类抗生素的抗生素复方
EP1958630A1 (fr) * 2007-02-13 2008-08-20 LEK Pharmaceuticals d.d. Combinaison anti-bactérienne d'un carbapénèm tricyclique et un antibiotique

Also Published As

Publication number Publication date
JP2012505196A (ja) 2012-03-01
EA201170532A1 (ru) 2011-12-30
CL2011000783A1 (es) 2012-07-06
CN102216301B (zh) 2014-12-10
BRPI0919812A2 (pt) 2015-12-22
PA8845401A1 (es) 2010-05-26
ZA201102498B (en) 2013-07-25
PE20110392A1 (es) 2011-06-11
IL212180A0 (en) 2011-06-30
AR073771A1 (es) 2010-12-01
AU2009302153A1 (en) 2010-04-15
CA2740035A1 (fr) 2010-04-15
MX2011003812A (es) 2011-07-29
KR20110067148A (ko) 2011-06-21
ECSP11010973A (es) 2011-06-30
US20100092443A1 (en) 2010-04-15
UY32168A (es) 2010-04-30
BRPI0919812A8 (pt) 2016-11-01
TW201026697A (en) 2010-07-16
WO2010041112A1 (fr) 2010-04-15
FR2936951A1 (fr) 2010-04-16
NZ592165A (en) 2012-12-21
EP2344500A1 (fr) 2011-07-20
CN102216301A (zh) 2011-10-12
CO6361930A2 (es) 2012-01-20

Similar Documents

Publication Publication Date Title
FR2936951B1 (fr) Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2936798B1 (fr) Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
BRPI1008178A2 (pt) "descarga de baterias"
IL218934A0 (en) Novel heterocyclic acrylamides and their use as phermaceuticals
SMT201500140B (it) Composizione per inibire l'espressione genica e suoi usi
FR2930553B1 (fr) Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases
FR2935382B1 (fr) Sel d'anion pentacylique et son utilisation comme electrolyte
BRPI0815948A2 (pt) "compostos heterocíclicos como antagonistas de receptorncrth2"
BRPI1010761A2 (pt) "composições semi-sólidas e produtos farmacêuticos"
FR2937034B1 (fr) Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
BRPI1008215A2 (pt) "composição azeotrópica"
HK1140506A1 (en) Polylactic acid composition and fiber composed of the same
ZA200906784B (en) New introgenous heterocyclic compounds preparation thereof and use thereof as antibacterial medicaments
ZA201103462B (en) Aryl piperazine and their use as alpha2c antagonists
ZA200905671B (en) Heterocyclic compounds, compositions comprising them and methods of their use
BR112012025270A2 (pt) "composição de cuidados pessoais"
FR2911102B1 (fr) Manteau de protection d'essieu
BRPI0916141A2 (pt) ''determinação de modo de ação de aceleração''
BRPI0910795A2 (pt) formulações apresentando compatibilidade aperfeiçoada com substratos não tecidos
DE602008005536D1 (de) Herstellung von MnB12H12
IT1404145B1 (it) Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi
FR2944524B1 (fr) Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
FR2944525B1 (fr) Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
BR112013007039A2 (pt) "composição de tratamento pessoal"
FR2926557B1 (fr) Synthese de nouveaux derives de neamine et leur utilisation comme agents antibacteriens

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20160630