DK1280809T3 - Antitumorecteinascidinderivater - Google Patents
AntitumorecteinascidinderivaterInfo
- Publication number
- DK1280809T3 DK1280809T3 DK01919669T DK01919669T DK1280809T3 DK 1280809 T3 DK1280809 T3 DK 1280809T3 DK 01919669 T DK01919669 T DK 01919669T DK 01919669 T DK01919669 T DK 01919669T DK 1280809 T3 DK1280809 T3 DK 1280809T3
- Authority
- DK
- Denmark
- Prior art keywords
- antitumorecteinascidin
- derivatives
- antitumorecteinascidin derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0009043A GB0009043D0 (en) | 2000-04-12 | 2000-04-12 | New autitumoural derivatives of ET-743 |
PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
GB0022644A GB0022644D0 (en) | 2000-09-14 | 2000-09-14 | Antitumoral derivatives of ET-743 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1280809T3 true DK1280809T3 (da) | 2005-11-07 |
Family
ID=26244092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01919669T DK1280809T3 (da) | 2000-04-12 | 2001-04-12 | Antitumorecteinascidinderivater |
Country Status (27)
Country | Link |
---|---|
US (1) | US7202361B2 (da) |
EP (1) | EP1280809B1 (da) |
JP (1) | JP5219323B2 (da) |
KR (1) | KR100886496B1 (da) |
CN (1) | CN1436191B (da) |
AR (1) | AR032879A1 (da) |
AT (1) | ATE299146T1 (da) |
AU (1) | AU784249C (da) |
BG (1) | BG65987B1 (da) |
BR (1) | BRPI0110024B8 (da) |
CA (1) | CA2406080C (da) |
CZ (1) | CZ304749B6 (da) |
DE (1) | DE60111845T2 (da) |
DK (1) | DK1280809T3 (da) |
EA (1) | EA006206B1 (da) |
ES (1) | ES2244598T3 (da) |
HK (1) | HK1049005B (da) |
HU (1) | HU230918B1 (da) |
IL (1) | IL152094A (da) |
MX (1) | MXPA02010088A (da) |
NO (1) | NO329125B1 (da) |
NZ (1) | NZ521550A (da) |
PL (1) | PL210703B1 (da) |
PT (1) | PT1280809E (da) |
SI (1) | SI1280809T1 (da) |
SK (1) | SK288017B6 (da) |
WO (1) | WO2001077115A1 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL139607A0 (en) * | 1998-05-11 | 2002-02-10 | Pharma Mar Sa | Metabolites of ecteinascidin 743 |
MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
BR0213424A (pt) * | 2001-10-19 | 2004-12-14 | Pharma Mar Sa | Uso aperfeiçoado de composto antitumoral na terapia contra câncer |
JP4208469B2 (ja) * | 2002-01-29 | 2009-01-14 | 独立行政法人科学技術振興機構 | エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法 |
GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
US7622458B2 (en) | 2003-11-13 | 2009-11-24 | Pharma Mar, S.A.U. | Combination of ET-743 and a 5-fluorouracil pro-drug for cancer treatment |
JP2008514688A (ja) * | 2004-09-29 | 2008-05-08 | ファルマ・マル・エス・アー, ソシエダッド・ユニペルソナル | 抗炎症剤としてのエクテイナシジン化合物 |
WO2006046079A1 (en) | 2004-10-29 | 2006-05-04 | Pharma Mar S.A., Sociedad Unipersonal | Formulations comprising ecteinascidin and a disaccharide |
WO2006083417A2 (en) * | 2004-12-20 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Processes of making sesquiterpenoid tashironin, its analogs and their uses |
WO2006079112A2 (en) * | 2005-01-18 | 2006-07-27 | The Trustees Of Columbia University In The City Of New York | Enantioselective synthesis of merrilactone a and its analogs |
GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
WO2007087220A2 (en) * | 2006-01-25 | 2007-08-02 | The Trustees Of Columbia University In The City Of New York | The total synthesis of ecteinascidin 743 and derivatives thereof |
FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
CN107033164A (zh) | 2010-05-25 | 2017-08-11 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
DK2786753T3 (da) | 2010-11-12 | 2019-04-15 | Pharma Mar Sa | Kombinationsterapi med et antitumorantibiotikum |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
CN112679513B (zh) * | 2019-10-18 | 2023-08-25 | 南通诺泰生物医药技术有限公司 | 一种制备曲贝替定的关键中间体的方法 |
CN114940682A (zh) * | 2022-05-18 | 2022-08-26 | 博瑞制药(苏州)有限公司 | 芦比替定的晶型及其制备方法和用途 |
CN115677728A (zh) * | 2022-11-02 | 2023-02-03 | 成都科岭源医药技术有限公司 | 一种海鞘素类化合物中间体的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
DE3774435D1 (de) | 1986-06-09 | 1991-12-12 | Univ Pennsylvania | Ekteinascidine 729, 743, 745, 759a, 759b and 770. |
US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
IL139607A0 (en) * | 1998-05-11 | 2002-02-10 | Pharma Mar Sa | Metabolites of ecteinascidin 743 |
US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
US6686470B2 (en) * | 2000-01-19 | 2004-02-03 | The Trustees Of Columbia University In The City Of New York | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
2001
- 2001-04-12 WO PCT/GB2001/001667 patent/WO2001077115A1/en active IP Right Grant
- 2001-04-12 AU AU46729/01A patent/AU784249C/en not_active Expired
- 2001-04-12 BR BR0110024-6 patent/BRPI0110024B8/pt not_active IP Right Cessation
- 2001-04-12 PT PT01919669T patent/PT1280809E/pt unknown
- 2001-04-12 EA EA200201083A patent/EA006206B1/ru not_active IP Right Cessation
- 2001-04-12 SI SI200130394T patent/SI1280809T1/sl unknown
- 2001-04-12 CZ CZ2002-3352A patent/CZ304749B6/cs not_active IP Right Cessation
- 2001-04-12 MX MXPA02010088A patent/MXPA02010088A/es active IP Right Grant
- 2001-04-12 ES ES01919669T patent/ES2244598T3/es not_active Expired - Lifetime
- 2001-04-12 DE DE60111845T patent/DE60111845T2/de not_active Expired - Lifetime
- 2001-04-12 SK SK1435-2002A patent/SK288017B6/sk not_active IP Right Cessation
- 2001-04-12 CA CA2406080A patent/CA2406080C/en not_active Expired - Lifetime
- 2001-04-12 AT AT01919669T patent/ATE299146T1/de active
- 2001-04-12 HU HU0300534A patent/HU230918B1/hu unknown
- 2001-04-12 DK DK01919669T patent/DK1280809T3/da active
- 2001-04-12 KR KR1020027013749A patent/KR100886496B1/ko active IP Right Grant
- 2001-04-12 US US10/240,963 patent/US7202361B2/en not_active Expired - Lifetime
- 2001-04-12 JP JP2001575588A patent/JP5219323B2/ja not_active Expired - Lifetime
- 2001-04-12 NZ NZ521550A patent/NZ521550A/en not_active IP Right Cessation
- 2001-04-12 CN CN01810939XA patent/CN1436191B/zh not_active Expired - Lifetime
- 2001-04-12 EP EP01919669A patent/EP1280809B1/en not_active Expired - Lifetime
- 2001-04-12 IL IL152094A patent/IL152094A/en active IP Right Grant
- 2001-04-12 PL PL357574A patent/PL210703B1/pl unknown
- 2001-04-16 AR ARP010101773A patent/AR032879A1/es active IP Right Grant
-
2002
- 2002-10-11 NO NO20024906A patent/NO329125B1/no not_active IP Right Cessation
- 2002-10-24 BG BG107220A patent/BG65987B1/bg unknown
-
2003
- 2003-02-20 HK HK03101292.0A patent/HK1049005B/zh not_active IP Right Cessation
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