PT1280809E - Derivados antitumorais de ecteinascidina - Google Patents

Derivados antitumorais de ecteinascidina

Info

Publication number
PT1280809E
PT1280809E PT01919669T PT01919669T PT1280809E PT 1280809 E PT1280809 E PT 1280809E PT 01919669 T PT01919669 T PT 01919669T PT 01919669 T PT01919669 T PT 01919669T PT 1280809 E PT1280809 E PT 1280809E
Authority
PT
Portugal
Prior art keywords
sub
dbd
alkyl
alkynyl
alkenyl
Prior art date
Application number
PT01919669T
Other languages
English (en)
Inventor
Ignacio Manzanares
Flores Maria
Francesch Andres
Gallego Pilar
Chicharro Jose Luis
Zarzuelo Maria
Fernandez Carolina
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0009043A external-priority patent/GB0009043D0/en
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Priority claimed from GB0022644A external-priority patent/GB0022644D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of PT1280809E publication Critical patent/PT1280809E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT01919669T 2000-04-12 2001-04-12 Derivados antitumorais de ecteinascidina PT1280809E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0009043A GB0009043D0 (en) 2000-04-12 2000-04-12 New autitumoural derivatives of ET-743
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
GB0022644A GB0022644D0 (en) 2000-09-14 2000-09-14 Antitumoral derivatives of ET-743

Publications (1)

Publication Number Publication Date
PT1280809E true PT1280809E (pt) 2005-11-30

Family

ID=26244092

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01919669T PT1280809E (pt) 2000-04-12 2001-04-12 Derivados antitumorais de ecteinascidina

Country Status (27)

Country Link
US (1) US7202361B2 (pt)
EP (1) EP1280809B1 (pt)
JP (1) JP5219323B2 (pt)
KR (1) KR100886496B1 (pt)
CN (1) CN1436191B (pt)
AR (1) AR032879A1 (pt)
AT (1) ATE299146T1 (pt)
AU (1) AU784249C (pt)
BG (1) BG65987B1 (pt)
BR (1) BRPI0110024B8 (pt)
CA (1) CA2406080C (pt)
CZ (1) CZ304749B6 (pt)
DE (1) DE60111845T2 (pt)
DK (1) DK1280809T3 (pt)
EA (1) EA006206B1 (pt)
ES (1) ES2244598T3 (pt)
HK (1) HK1049005B (pt)
HU (1) HU230918B1 (pt)
IL (1) IL152094A (pt)
MX (1) MXPA02010088A (pt)
NO (1) NO329125B1 (pt)
NZ (1) NZ521550A (pt)
PL (1) PL210703B1 (pt)
PT (1) PT1280809E (pt)
SI (1) SI1280809T1 (pt)
SK (1) SK288017B6 (pt)
WO (1) WO2001077115A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1077698B1 (en) * 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
RU2306933C2 (ru) * 2001-10-19 2007-09-27 Фарма Мар, С.А. Улучшенная схема применения противоопухолевого соединения в терапии рака
JP4208469B2 (ja) * 2002-01-29 2009-01-14 独立行政法人科学技術振興機構 エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
ATE406897T1 (de) 2003-11-13 2008-09-15 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
US8067462B2 (en) * 2004-12-20 2011-11-29 The Trustees Of Columbia University In The City Of New York Processes of making sesquiterpenoid tashironin, its analogs and their uses
WO2006079112A2 (en) * 2005-01-18 2006-07-27 The Trustees Of Columbia University In The City Of New York Enantioselective synthesis of merrilactone a and its analogs
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2007087220A2 (en) * 2006-01-25 2007-08-02 The Trustees Of Columbia University In The City Of New York The total synthesis of ecteinascidin 743 and derivatives thereof
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
ES2534331T3 (es) 2010-05-25 2015-04-21 Pharma Mar S.A. Proceso sintético para la producción de compuestos e intermedios de ecteinascidina
RS58609B1 (sr) 2010-11-12 2019-05-31 Pharma Mar Sa Kombinovana terapija sa inhibitorom mitoze
JOP20190254A1 (ar) * 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN112679513B (zh) * 2019-10-18 2023-08-25 南通诺泰生物医药技术有限公司 一种制备曲贝替定的关键中间体的方法
CN114940682A (zh) * 2022-05-18 2022-08-26 博瑞制药(苏州)有限公司 芦比替定的晶型及其制备方法和用途
CN115677728A (zh) * 2022-11-02 2023-02-03 成都科岭源医药技术有限公司 一种海鞘素类化合物中间体的制备方法
WO2024155565A2 (en) * 2023-01-17 2024-07-25 Yarrow Therapeutics, Inc. Ecteinascidin derivative antibody drug conjugates

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
AU589282B2 (en) 1986-06-09 1989-10-05 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5721365A (en) * 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1077698B1 (en) 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
AU783562B2 (en) * 2000-01-19 2005-11-10 Trustees Of Columbia University In The City Of New York, The Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
BRPI0110024B8 (pt) 2021-05-25
ATE299146T1 (de) 2005-07-15
KR20030012864A (ko) 2003-02-12
IL152094A0 (en) 2003-05-29
KR100886496B1 (ko) 2009-03-05
HK1049005B (zh) 2006-01-27
BG107220A (en) 2003-05-30
BG65987B1 (bg) 2010-08-31
ES2244598T3 (es) 2005-12-16
CN1436193A (zh) 2003-08-13
BR0110024A (pt) 2003-02-18
AU4672901A (en) 2001-10-23
US7202361B2 (en) 2007-04-10
CZ304749B6 (cs) 2014-09-24
DK1280809T3 (da) 2005-11-07
NO20024906D0 (no) 2002-10-11
HUP0300534A3 (en) 2006-02-28
IL152094A (en) 2011-10-31
PL357574A1 (en) 2004-07-26
DE60111845D1 (de) 2005-08-11
NO329125B1 (no) 2010-08-30
WO2001077115A1 (en) 2001-10-18
EP1280809B1 (en) 2005-07-06
EA200201083A1 (ru) 2003-04-24
HUP0300534A2 (hu) 2003-07-28
HU230918B1 (hu) 2019-03-28
AU784249C (en) 2007-05-03
NO20024906L (no) 2002-11-27
BRPI0110024B1 (pt) 2019-07-16
JP2003530402A (ja) 2003-10-14
CA2406080C (en) 2011-11-29
AU784249B2 (en) 2006-02-23
CZ20023352A3 (cs) 2003-05-14
EP1280809A1 (en) 2003-02-05
JP5219323B2 (ja) 2013-06-26
NZ521550A (en) 2004-10-29
CA2406080A1 (en) 2001-10-18
HK1049005A1 (en) 2003-04-25
AR032879A1 (es) 2003-12-03
SK288017B6 (sk) 2012-11-05
US20030216397A1 (en) 2003-11-20
SK14352002A3 (sk) 2003-04-01
PL210703B1 (pl) 2012-02-29
EA006206B1 (ru) 2005-10-27
SI1280809T1 (sl) 2005-12-31
DE60111845T2 (de) 2006-04-27
MXPA02010088A (es) 2004-08-19
CN1436191B (zh) 2011-09-14

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