BR0213424A - Uso aperfeiçoado de composto antitumoral na terapia contra câncer - Google Patents
Uso aperfeiçoado de composto antitumoral na terapia contra câncerInfo
- Publication number
- BR0213424A BR0213424A BR0213424-1A BR0213424A BR0213424A BR 0213424 A BR0213424 A BR 0213424A BR 0213424 A BR0213424 A BR 0213424A BR 0213424 A BR0213424 A BR 0213424A
- Authority
- BR
- Brazil
- Prior art keywords
- cancer therapy
- improved use
- antitumor compound
- improved
- compound
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000011275 oncology therapy Methods 0.000 title abstract 2
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 abstract 1
- 229960000977 trabectedin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
Abstract
"USO APERFEIçOADO DE COMPOSTO ANTITUMORAL NA TERAPIA CONTRA CâNCER". A presente invenção refere-se a programas aperfeiçoados de dosagem de ecteinascidina 743 que são empregados para tratamento de câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34841401P | 2001-10-19 | 2001-10-19 | |
PCT/US2002/033548 WO2003039571A1 (en) | 2001-10-19 | 2002-10-21 | Improved use of antitumoral compound in cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213424A true BR0213424A (pt) | 2004-12-14 |
Family
ID=23367939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213424-1A BR0213424A (pt) | 2001-10-19 | 2002-10-21 | Uso aperfeiçoado de composto antitumoral na terapia contra câncer |
Country Status (15)
Country | Link |
---|---|
US (1) | US20050004018A1 (pt) |
EP (1) | EP1435988A4 (pt) |
JP (1) | JP2005509650A (pt) |
KR (1) | KR20050038578A (pt) |
CN (1) | CN1606449A (pt) |
AU (1) | AU2002343548B2 (pt) |
BR (1) | BR0213424A (pt) |
CA (1) | CA2462502A1 (pt) |
HU (1) | HUP0401903A3 (pt) |
IL (1) | IL161430A0 (pt) |
MX (1) | MXPA04003674A (pt) |
NO (1) | NO20042035L (pt) |
PL (1) | PL368458A1 (pt) |
RU (1) | RU2306933C2 (pt) |
WO (1) | WO2003039571A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
DK1365808T3 (da) * | 2000-11-06 | 2011-05-16 | Pharma Mar Sa | Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743 |
GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
ATE406897T1 (de) | 2003-11-13 | 2008-09-15 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs |
EP1691809A1 (en) * | 2003-11-14 | 2006-08-23 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
EP1768671A2 (en) * | 2004-07-09 | 2007-04-04 | Pharma Mar, S.A. | Use of ecteinascidin in the treatment of cancer in patients with low level of brca1 |
ATE430586T1 (de) * | 2004-10-26 | 2009-05-15 | Pharma Mar Sa | Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743 |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
US20100009906A1 (en) * | 2006-05-12 | 2010-01-14 | Pharma Mar, S.A. | Anticancer Treatments |
PL2129396T3 (pl) | 2007-02-16 | 2014-02-28 | Merrimack Pharmaceuticals Inc | Przeciwciała przeciw ERBB3 i ich zastosowania |
JP2011500046A (ja) * | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Et−743治療のための予後分子マーカー |
BRPI0917871A2 (pt) * | 2008-08-15 | 2017-06-20 | Merrimack Pharmaceuticals Inc | agente terapêutico anti-erbb3 para uso em terapia de um tumor, métodos para predizer responsividade de um tumor de um agente terapêutco anti-erbb3, para selecionar terapia anti-erbb3 para um paciente, para predizer a resposta de células ao tratamento com um agente terapêutico, para identificar um biomarcador, e para evitar administração de uma droga para câncer anti-erbb3, e, kit para predizer a resposta das células ao tratamento com um agente terapêutico |
EP2859893A1 (en) | 2010-03-11 | 2015-04-15 | Merrimack Pharmaceuticals, Inc. | Use of ERBB3 inhibitors in the treatment of triple negative and basal-like breast cancers |
WO2013012760A1 (en) | 2011-07-15 | 2013-01-24 | Numeta Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
GB201217439D0 (en) * | 2012-09-28 | 2012-11-14 | Topotarget As | Combination therapy |
CA2891335C (en) | 2012-11-13 | 2021-05-04 | Nusirt Sciences, Inc. | Compositions and methods for increasing energy metabolism |
EP3087394A2 (en) | 2013-12-27 | 2016-11-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
PT1280809E (pt) * | 2000-04-12 | 2005-11-30 | Pharma Mar Sa | Derivados antitumorais de ecteinascidina |
DK1365808T3 (da) * | 2000-11-06 | 2011-05-16 | Pharma Mar Sa | Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743 |
GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
-
2002
- 2002-10-21 RU RU2004115110/14A patent/RU2306933C2/ru not_active IP Right Cessation
- 2002-10-21 US US10/492,320 patent/US20050004018A1/en not_active Abandoned
- 2002-10-21 IL IL16143002A patent/IL161430A0/xx unknown
- 2002-10-21 CA CA002462502A patent/CA2462502A1/en not_active Abandoned
- 2002-10-21 EP EP02780496A patent/EP1435988A4/en not_active Withdrawn
- 2002-10-21 WO PCT/US2002/033548 patent/WO2003039571A1/en active Application Filing
- 2002-10-21 KR KR1020047005765A patent/KR20050038578A/ko not_active Application Discontinuation
- 2002-10-21 AU AU2002343548A patent/AU2002343548B2/en not_active Ceased
- 2002-10-21 BR BR0213424-1A patent/BR0213424A/pt not_active IP Right Cessation
- 2002-10-21 CN CNA028256662A patent/CN1606449A/zh active Pending
- 2002-10-21 JP JP2003541862A patent/JP2005509650A/ja active Pending
- 2002-10-21 MX MXPA04003674A patent/MXPA04003674A/es not_active Application Discontinuation
- 2002-10-21 HU HU0401903A patent/HUP0401903A3/hu unknown
- 2002-10-21 PL PL02368458A patent/PL368458A1/xx not_active Application Discontinuation
-
2004
- 2004-05-18 NO NO20042035A patent/NO20042035L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL161430A0 (en) | 2004-09-27 |
CA2462502A1 (en) | 2003-05-15 |
RU2004115110A (ru) | 2005-03-10 |
AU2002343548B2 (en) | 2007-11-08 |
PL368458A1 (en) | 2005-03-21 |
KR20050038578A (ko) | 2005-04-27 |
US20050004018A1 (en) | 2005-01-06 |
AU2002343548B8 (en) | 2003-05-19 |
EP1435988A4 (en) | 2008-01-09 |
NO20042035L (no) | 2004-05-18 |
JP2005509650A (ja) | 2005-04-14 |
CN1606449A (zh) | 2005-04-13 |
MXPA04003674A (es) | 2004-07-23 |
HUP0401903A2 (hu) | 2005-01-28 |
WO2003039571A1 (en) | 2003-05-15 |
EP1435988A1 (en) | 2004-07-14 |
RU2306933C2 (ru) | 2007-09-27 |
HUP0401903A3 (en) | 2008-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE A 8.6, DA RPI 2108 DE 31/05/2011. |