PT1085884E - Combinacao de compostos seleniferos com gemcitabina ou mitomicina c - Google Patents
Combinacao de compostos seleniferos com gemcitabina ou mitomicina cInfo
- Publication number
- PT1085884E PT1085884E PT99927815T PT99927815T PT1085884E PT 1085884 E PT1085884 E PT 1085884E PT 99927815 T PT99927815 T PT 99927815T PT 99927815 T PT99927815 T PT 99927815T PT 1085884 E PT1085884 E PT 1085884E
- Authority
- PT
- Portugal
- Prior art keywords
- selenium
- combination
- present
- cytostatics
- effect
- Prior art date
Links
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title 1
- 229960005277 gemcitabine Drugs 0.000 title 1
- 239000000824 cytostatic agent Substances 0.000 abstract 4
- 230000001085 cytostatic effect Effects 0.000 abstract 4
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 229910052711 selenium Inorganic materials 0.000 abstract 3
- 239000011669 selenium Substances 0.000 abstract 3
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 229940065287 selenium compound Drugs 0.000 abstract 2
- 150000003343 selenium compounds Chemical class 0.000 abstract 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 abstract 1
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 208000000649 small cell carcinoma Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825746A DE19825746A1 (de) | 1998-06-09 | 1998-06-09 | Kombination von Selen-haltigen Verbindungen mit Zytostatika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1085884E true PT1085884E (pt) | 2005-07-29 |
Family
ID=7870407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99927815T PT1085884E (pt) | 1998-06-09 | 1999-05-31 | Combinacao de compostos seleniferos com gemcitabina ou mitomicina c |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6656509B1 (pt) |
| EP (1) | EP1085884B1 (pt) |
| AT (1) | ATE290388T1 (pt) |
| CA (1) | CA2334527C (pt) |
| DE (2) | DE19825746A1 (pt) |
| ES (1) | ES2237920T3 (pt) |
| PT (1) | PT1085884E (pt) |
| WO (1) | WO1999064018A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10321029A1 (de) * | 2003-05-10 | 2004-12-02 | Sigrid Heide | Arzneimittel mit Selenit |
| JP2006528696A (ja) * | 2003-05-13 | 2006-12-21 | ヘルス リサーチ インコーポレイテッド | 抗癌剤の抗腫瘍活性を増強する方法 |
| US20060258697A1 (en) * | 2003-05-13 | 2006-11-16 | Rustum Youcef M | Method of augmenting the antitumor activity of anticancer agents |
| PL214402B1 (pl) * | 2003-08-11 | 2013-07-31 | Tomasz Byrski | Zastosowanie selenu albo jego zwiazku do otrzymywania srodka do obnizania odziedziczonego ryzyka zachorowania na raka piersi lub jajnika |
| US7534818B1 (en) | 2003-09-15 | 2009-05-19 | Health Research, Inc. | Method of reducing alopecia and bladder toxicity of cyclophosphamide |
| US8932649B2 (en) * | 2003-11-14 | 2015-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds |
| US8221803B1 (en) | 2007-06-25 | 2012-07-17 | OncoNatural Solutions, Inc. | Composition for prostate health |
| MD4014C2 (ro) * | 2009-04-23 | 2010-09-30 | Татьяна ГУЦУЛ | Complecşi polioxometalaţi cu activitate antitumorală |
| CA2806660A1 (en) | 2010-07-26 | 2012-02-09 | Chemotherapeutics, Llc | Compositions and methods for enhancing the effectiveness of systemic, hipec, ip, and related cancer treatments |
| WO2012071383A2 (en) * | 2010-11-22 | 2012-05-31 | Board Of Regents, The University Of Texas System | Methods and compositions to eliminate chronic lymphocytic leukemia and other hematologic malignant cells in stromal microenvironment for cancer therapy |
| MD4282C1 (ro) * | 2012-12-11 | 2014-11-30 | ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ | Utilizarea complecşilor polioxometalaţi cu atomi de seleniu centrali în calitate de compuşi cu activitate antitumorală |
| FR3037798A1 (fr) * | 2015-06-25 | 2016-12-30 | Serenite-Forceville | Composition comprenant au moins un compose selenie pour le traitement du sepsis et/ou de toute hyper-inflammation generalisee (sirs) ou cellulaire dommageable |
| EP3389676A1 (en) * | 2015-12-16 | 2018-10-24 | Pharma Nord ApS | Dosage regimen of sodium selenite in the treatment of cancer |
| EP3409303A1 (en) * | 2017-06-02 | 2018-12-05 | Geistlich Pharma AG | Use of a resorbable crosslinked form stable composition for preparing a membrane |
| WO2019224428A1 (en) * | 2018-05-22 | 2019-11-28 | Seleq Oy | Pharmaceutical compositions for the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385726A (en) | 1990-08-06 | 1995-01-31 | Rhone-Poulenc Rorer Gmbh | Use of 2-phenyl-1,2-benzisoselenazol-3-(2H)-one |
| DE4024885C2 (de) | 1990-08-06 | 2002-07-18 | Nattermann A & Cie | Verwendung von 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
| US5783454A (en) * | 1994-05-17 | 1998-07-21 | Spallholz; Julian E. | Method for the preparation of free radical pharmaceuticals using selenium conjugates |
| EP0750911B1 (en) * | 1995-06-07 | 2003-09-10 | Life Science Labs, Inc. | Composition containing selenium to reduce cancer incidence and extend lifespan |
-
1998
- 1998-06-09 DE DE19825746A patent/DE19825746A1/de not_active Ceased
-
1999
- 1999-05-31 EP EP99927815A patent/EP1085884B1/de not_active Expired - Lifetime
- 1999-05-31 AT AT99927815T patent/ATE290388T1/de active
- 1999-05-31 US US09/701,326 patent/US6656509B1/en not_active Expired - Lifetime
- 1999-05-31 PT PT99927815T patent/PT1085884E/pt unknown
- 1999-05-31 ES ES99927815T patent/ES2237920T3/es not_active Expired - Lifetime
- 1999-05-31 WO PCT/EP1999/003771 patent/WO1999064018A1/de active IP Right Grant
- 1999-05-31 CA CA002334527A patent/CA2334527C/en not_active Expired - Fee Related
- 1999-05-31 DE DE59911734T patent/DE59911734D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999064018A1 (de) | 1999-12-16 |
| ATE290388T1 (de) | 2005-03-15 |
| CA2334527C (en) | 2004-11-23 |
| DE19825746A1 (de) | 1999-12-16 |
| ES2237920T3 (es) | 2005-08-01 |
| EP1085884B1 (de) | 2005-03-09 |
| EP1085884A1 (de) | 2001-03-28 |
| DE59911734D1 (de) | 2005-04-14 |
| US6656509B1 (en) | 2003-12-02 |
| CA2334527A1 (en) | 1999-12-16 |
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