BR0008447A - Métodos de tratamento de distúrbios mitocondriais - Google Patents

Métodos de tratamento de distúrbios mitocondriais

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Publication number
BR0008447A
BR0008447A BR0008447-6A BR0008447A BR0008447A BR 0008447 A BR0008447 A BR 0008447A BR 0008447 A BR0008447 A BR 0008447A BR 0008447 A BR0008447 A BR 0008447A
Authority
BR
Brazil
Prior art keywords
methods
mitochondrial disorders
treating mitochondrial
treating
disorders
Prior art date
Application number
BR0008447-6A
Other languages
English (en)
Inventor
Robert K Naviaux
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR0008447A publication Critical patent/BR0008447A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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Abstract

Patente de Invenção: "MéTODOS DE TRATAMENTO DE DISTúRBIOS MITOCONDRIAIS". De acordo com a presente invenção, são providos métodos para o tratamento de distúrbios mitocondriais. Os métodos da invenção incluem a administração de um nucleosídeo à base de pirimidina como triacetiluridina, ou outros. São também providos métodos para reduzir ou eliminar sintomas associados com distúrbios mitocondriais. Os distúrbios mitocondriais particularmente apropriados para o tratamento incluem os atribuíveis a uma deficiência de uma ou mais pirimidinas.
BR0008447-6A 1999-02-23 2000-02-23 Métodos de tratamento de distúrbios mitocondriais BR0008447A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12158899P 1999-02-23 1999-02-23
PCT/US2000/004663 WO2000050043A1 (en) 1999-02-23 2000-02-23 Methods of treatment of mitochondrial disorders

Publications (1)

Publication Number Publication Date
BR0008447A true BR0008447A (pt) 2002-01-15

Family

ID=22397641

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008447-6A BR0008447A (pt) 1999-02-23 2000-02-23 Métodos de tratamento de distúrbios mitocondriais

Country Status (20)

Country Link
US (2) US7638501B1 (pt)
EP (2) EP1171137B1 (pt)
JP (1) JP4776780B2 (pt)
KR (2) KR100758712B1 (pt)
CN (2) CN1191835C (pt)
AT (1) ATE381935T1 (pt)
AU (1) AU776437B2 (pt)
BR (1) BR0008447A (pt)
CA (1) CA2362925C (pt)
DE (1) DE60037578T2 (pt)
DK (1) DK1171137T3 (pt)
ES (1) ES2298130T3 (pt)
HU (1) HU230191B1 (pt)
IL (3) IL144964A0 (pt)
MX (1) MXPA01008549A (pt)
NZ (1) NZ513926A (pt)
PT (1) PT1171137E (pt)
RU (2) RU2268732C2 (pt)
WO (1) WO2000050043A1 (pt)
ZA (1) ZA200107727B (pt)

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HUP0400914A2 (hu) 2004-08-30
EP1171137A4 (en) 2004-04-07
ZA200107727B (en) 2007-10-31
RU2001125913A (ru) 2005-02-20
EP1808177B1 (en) 2018-08-08
HU230191B1 (hu) 2015-09-28
RU2268732C2 (ru) 2006-01-27
WO2000050043A1 (en) 2000-08-31
US20100098678A1 (en) 2010-04-22
AU2004235661A1 (en) 2005-01-27
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US7638501B1 (en) 2009-12-29
IL144964A (en) 2013-11-28
CA2362925A1 (en) 2000-08-31
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CN1341024A (zh) 2002-03-20
AU3243400A (en) 2000-09-14
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ATE381935T1 (de) 2008-01-15
HUP0400914A3 (en) 2007-05-29
JP4776780B2 (ja) 2011-09-21
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MXPA01008549A (es) 2003-06-06
RU2394580C2 (ru) 2010-07-20
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US8748408B2 (en) 2014-06-10
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