HUP0400914A2 - Eljárások mitokondriális betegségek kezelésére - Google Patents
Eljárások mitokondriális betegségek kezeléséreInfo
- Publication number
- HUP0400914A2 HUP0400914A2 HU0400914A HUP0400914A HUP0400914A2 HU P0400914 A2 HUP0400914 A2 HU P0400914A2 HU 0400914 A HU0400914 A HU 0400914A HU P0400914 A HUP0400914 A HU P0400914A HU P0400914 A2 HUP0400914 A2 HU P0400914A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- formula
- alkyl
- treatment
- Prior art date
Links
- 208000012268 mitochondrial disease Diseases 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya eljárás mitokondriális rendellenességgelkapcsolatos egy vagy több tünet enyhítésére vagy megszüntetésére, amiabból áll, hogy a kezelésre szoruló szervezetbe az (I) általánosképletű - ahol R1 jelentése OH, NHCOCH3 vagy NH2 képletű csoport; R2jelentése hidrogénatom, CO2H képletű csoport vagy -C(=O)O-(CX2)0-21-CX3 (II) általános képletű csoport, melyen belül X jelentése 1-22szénatomos alkil-, 1-22 szénatomos alkenil-, 1-22 szénatomosalkinilcsoport, melyek hidrogénatommal, 1-3 szénatomosalkilcsoporttal, OH, NH2 képletű csoporttal vagy halogénatommalhelyettesítettek; vagy X jelentése hidrogénatom; R3, R4 és R5jelentése egymástól függetlenül hidrogénatom vagy 1-22 szénatomosalkil-karbonil-csoport, mely adott esetben 1-3 szénatomos alkil-, OH,NH2 képletű csoporttal vagy halogénatommal helyettesített; és ahol azR3, R4 és R5 legalább egyikének jelentése nem hidrogénatom - vegyülethatásos mennyiségét juttatják. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12158899P | 1999-02-23 | 1999-02-23 | |
US60/121,588 | 1999-02-23 | ||
PCT/US2000/004663 WO2000050043A1 (en) | 1999-02-23 | 2000-02-23 | Methods of treatment of mitochondrial disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0400914A2 true HUP0400914A2 (hu) | 2004-08-30 |
HUP0400914A3 HUP0400914A3 (en) | 2007-05-29 |
HU230191B1 HU230191B1 (hu) | 2015-09-28 |
Family
ID=22397641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400914A HU230191B1 (hu) | 1999-02-23 | 2000-02-23 | Nukleozidok mitokondriális betegségek kezelésére |
Country Status (20)
Country | Link |
---|---|
US (2) | US7638501B1 (hu) |
EP (2) | EP1171137B1 (hu) |
JP (1) | JP4776780B2 (hu) |
KR (2) | KR100758712B1 (hu) |
CN (2) | CN1191835C (hu) |
AT (1) | ATE381935T1 (hu) |
AU (1) | AU776437B2 (hu) |
BR (1) | BR0008447A (hu) |
CA (1) | CA2362925C (hu) |
DE (1) | DE60037578T2 (hu) |
DK (1) | DK1171137T3 (hu) |
ES (1) | ES2298130T3 (hu) |
HU (1) | HU230191B1 (hu) |
IL (3) | IL144964A0 (hu) |
MX (1) | MXPA01008549A (hu) |
NZ (1) | NZ513926A (hu) |
PT (1) | PT1171137E (hu) |
RU (2) | RU2394580C2 (hu) |
WO (1) | WO2000050043A1 (hu) |
ZA (1) | ZA200107727B (hu) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
ES2332669T3 (es) * | 1998-07-31 | 2010-02-10 | Massachusetts Institute Of Technology | Uso de uridina en combinacion con colina para el tratamiento de trastornos de la memoria. |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
DK1171137T3 (da) | 1999-02-23 | 2008-03-31 | Univ California | Anvendelse af triacetyluridin til behandling af mitochondriale lidelser |
US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
DE10110355A1 (de) | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
CA2444148A1 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
IL159047A0 (en) * | 2001-05-29 | 2004-05-12 | Univ British Columbia | Pharmacological applications of mitochondrial dna assay |
JP2004182705A (ja) * | 2002-10-11 | 2004-07-02 | Yasutoshi Koga | ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物 |
CA2513529A1 (en) * | 2003-01-17 | 2004-08-19 | Cv Therapeutics Inc. | Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases |
CA2610152C (en) | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
SI1933821T1 (sl) | 2005-09-15 | 2020-11-30 | Ptc Therapeutics, Inc. | Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev |
EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
CN101896119A (zh) | 2007-11-02 | 2010-11-24 | 麻省理工学院 | 尿苷饮食添加顺应性方法及其用途 |
CN101612110B (zh) * | 2008-06-23 | 2012-07-25 | 欣凯医药化工中间体(上海)有限公司 | 三乙酰尿苷缓释制剂及其制备方法 |
WO2010030607A1 (en) | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
ES2640485T3 (es) | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
US20170209476A1 (en) * | 2014-08-19 | 2017-07-27 | Wellstat Therapeutics Corporation | Treatment of Glycosylation Deficiency Diseases |
FR3027804A1 (fr) * | 2014-10-31 | 2016-05-06 | Centre Nat Rech Scient | Utilisation d'un inhibiteur de transcriptase inverse dans la prevention et le traitement des maladies degeneratives |
AU2016270297B2 (en) | 2015-05-29 | 2019-12-12 | National Yang-Ming University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
LT3302499T (lt) * | 2015-06-05 | 2023-05-25 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Mitochondrinių ligų gydymas |
DK3505174T3 (da) * | 2015-06-17 | 2020-07-13 | Univ Columbia | Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer |
CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
KR101981843B1 (ko) | 2016-09-13 | 2019-05-23 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 미토콘드리아 기능 개선용 조성물 |
JP2021519334A (ja) | 2018-03-26 | 2021-08-10 | クリア クリーク バイオ, インコーポレイテッド | ジヒドロオロト酸デヒドロゲナーゼを阻害するための組成物および方法 |
CN114340641A (zh) * | 2019-09-05 | 2022-04-12 | 米托瑞因博治疗股份有限公司 | 治疗线粒体dna缺失障碍 |
KR102290596B1 (ko) * | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도 |
EP3970713A1 (en) * | 2020-09-16 | 2022-03-23 | GV Squared S.r.l. | Pharmaceutical composition comprising uridine and pyruvate for regulating the profileration, activity and survival of immune cells |
CN113116900B (zh) * | 2021-04-14 | 2022-07-08 | 兰州大学 | 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用 |
BE1030026B1 (fr) * | 2022-06-14 | 2023-07-07 | Dendrogenix | Composés dérivés de stérols et composition pharmaceutique les comprenant pour leur utilisation dans la prévention, l’amélioration et/ou le traitement d’une pathologie liée à un déficit mitochondrial |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5356690A (en) * | 1976-09-30 | 1978-05-23 | Rikagaku Kenkyusho | Purin compund sugar derivatives and their preparation |
US5736531A (en) | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
US6348451B1 (en) | 1987-10-28 | 2002-02-19 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
US6054441A (en) | 1987-10-28 | 2000-04-25 | Pro-Neuron, Inc. | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US5470838A (en) | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US6743782B1 (en) | 1987-10-28 | 2004-06-01 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
CA1329932C (en) | 1987-10-28 | 1994-05-31 | Reid Von Borstel | Acyl deoxyribonucleoside derivatives and uses thereof |
WO1989003837A1 (en) * | 1987-10-28 | 1989-05-05 | Pro-Neuron, Inc. | Acylated uridine and cytidine and uses thereof |
IT1219667B (it) | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
IT1241984B (it) | 1990-06-13 | 1994-02-02 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete |
US5981601A (en) * | 1992-05-28 | 1999-11-09 | Centre For Molecular Biology And Medicine | Method for enhancing cellular bioenergy |
US5567689A (en) | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
US5852000A (en) | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
CA2186636A1 (en) * | 1994-03-30 | 1995-10-12 | Corinna Herrnstadt | Diagnosis, therapy and cellular and animal models for diseases associated with mitochondrial defects |
JP3808121B2 (ja) * | 1995-01-09 | 2006-08-09 | 日本メジフィジックス株式会社 | 低酸素症またはミトコンドリア機能障害診断剤 |
US5962459A (en) | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
JPH10273469A (ja) * | 1997-02-03 | 1998-10-13 | Takeda Chem Ind Ltd | 2環性キノン誘導体、製造法および剤 |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
DK1171137T3 (da) | 1999-02-23 | 2008-03-31 | Univ California | Anvendelse af triacetyluridin til behandling af mitochondriale lidelser |
-
2000
- 2000-02-23 DK DK00910321T patent/DK1171137T3/da active
- 2000-02-23 JP JP2000600654A patent/JP4776780B2/ja not_active Expired - Lifetime
- 2000-02-23 IL IL14496400A patent/IL144964A0/xx unknown
- 2000-02-23 CA CA2362925A patent/CA2362925C/en not_active Expired - Fee Related
- 2000-02-23 BR BR0008447-6A patent/BR0008447A/pt not_active Application Discontinuation
- 2000-02-23 EP EP00910321A patent/EP1171137B1/en not_active Expired - Lifetime
- 2000-02-23 EP EP07008953.7A patent/EP1808177B1/en not_active Expired - Lifetime
- 2000-02-23 KR KR1020017010801A patent/KR100758712B1/ko not_active IP Right Cessation
- 2000-02-23 CN CNB008041032A patent/CN1191835C/zh not_active Expired - Fee Related
- 2000-02-23 KR KR1020077012846A patent/KR100879559B1/ko not_active IP Right Cessation
- 2000-02-23 PT PT00910321T patent/PT1171137E/pt unknown
- 2000-02-23 WO PCT/US2000/004663 patent/WO2000050043A1/en active IP Right Grant
- 2000-02-23 RU RU2005121711/14A patent/RU2394580C2/ru not_active IP Right Cessation
- 2000-02-23 DE DE60037578T patent/DE60037578T2/de not_active Expired - Lifetime
- 2000-02-23 AU AU32434/00A patent/AU776437B2/en not_active Ceased
- 2000-02-23 HU HU0400914A patent/HU230191B1/hu not_active IP Right Cessation
- 2000-02-23 ES ES00910321T patent/ES2298130T3/es not_active Expired - Lifetime
- 2000-02-23 CN CNB2004100784053A patent/CN100379426C/zh not_active Expired - Fee Related
- 2000-02-23 US US09/889,251 patent/US7638501B1/en not_active Expired - Fee Related
- 2000-02-23 NZ NZ513926A patent/NZ513926A/en not_active IP Right Cessation
- 2000-02-23 AT AT00910321T patent/ATE381935T1/de active
- 2000-02-23 MX MXPA01008549A patent/MXPA01008549A/es active IP Right Grant
- 2000-02-23 RU RU2001125913/14A patent/RU2268732C2/ru not_active IP Right Cessation
-
2001
- 2001-08-19 IL IL144964A patent/IL144964A/en not_active IP Right Cessation
- 2001-09-19 ZA ZA200107727A patent/ZA200107727B/en unknown
-
2007
- 2007-01-03 IL IL180528A patent/IL180528A/en not_active IP Right Cessation
-
2009
- 2009-12-21 US US12/643,920 patent/US8748408B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0400914A2 (hu) | Eljárások mitokondriális betegségek kezelésére | |
DE69629238D1 (de) | Vorrichtung zur Behandlung des Atemstillstands im Schlaf durch Elektrostimulation | |
HUP9903971A1 (hu) | Izoflavonok alkalmazása klimax elleni gyógyszerkészítmények előállítására | |
DE69527903D1 (de) | Vorrichtung zur Behandlung des obstruktiven Atemstillstand im Schlaf | |
ATE336239T1 (de) | Neue fettsäureanaloge zur behandlung des bluthochdrucks | |
DE60112942D1 (de) | Verbindungen zur behandlung der alzheimerischen krankheit | |
DE60024660D1 (de) | Menschliche rnase h und entsprechende oligonukleotidverbindungen | |
DE60220422D1 (de) | Substituierte pyrazoloverbindungen zur behandlung von entzündungen | |
DK0867184T3 (da) | Anvendelse af tiagabin til behandling af søvnforstyrrelser | |
DE60114002D1 (de) | VERFAHREN ZUR HERSTELLUNG KRISTALLINEr PARTIKEL ZUR INHALATION | |
HUP0102961A2 (hu) | Szerves fémvegyület alkalmazása keratintartalmú anyagok védelmére és/vagy erősítésére, és kezelési eljárás | |
MXPA04004300A (es) | Analogos de lipoxina a4. | |
ATE389395T1 (de) | Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson | |
IL160045A0 (en) | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues | |
HUP0402235A2 (hu) | 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények | |
HUP0104339A2 (hu) | Eljárás porckárosodások kezelésére | |
HUP0101258A2 (hu) | Helyettesített bisz-indolil-maleimidek, sejtburjánzás gátlására történő felhasználásra | |
TW200728357A (en) | Polycarbosilane, manufacture method of the same, silicon dioxide based composition for coatings and silicon dioxide film | |
DK0865271T4 (da) | Anvendelse af 2-ethylhexyl alfa-cyano-beta, beta-diphenylacrylat med henblik på at forbedre stabiliteten over for lys af p-methylbenzyliden-kamfer | |
BR9507444A (pt) | Processo de preparação de trialcoilsilil 7 bacatina III | |
DE69816244D1 (de) | Verwendung von 2-Aryl-3-aroylbenzo(b)thiophene zur Behandlung des Oestrogenenthaltungssyndroms | |
EE200000163A (et) | Protsess kirurgiliste instrumentide puhastamiseks | |
HUP0302408A2 (hu) | Új aminotriazolon-vegyületek, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények | |
DE60003681D1 (de) | Instrument zur Behandlung der Zahnwurzelkanäle | |
ATE306271T1 (de) | Kombination von loteprednol und beta2- adrenozeptor-agonisten und ihre verwendung durch inhalation zur behandlung von asthma bronchiale |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of definitive patent protection due to non-payment of fees |