SI1933821T1 - Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev - Google Patents
Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcevInfo
- Publication number
- SI1933821T1 SI1933821T1 SI200632388T SI200632388T SI1933821T1 SI 1933821 T1 SI1933821 T1 SI 1933821T1 SI 200632388 T SI200632388 T SI 200632388T SI 200632388 T SI200632388 T SI 200632388T SI 1933821 T1 SI1933821 T1 SI 1933821T1
- Authority
- SI
- Slovenia
- Prior art keywords
- redox
- modulation
- treatment
- conditions
- energy biomarkers
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A61P27/16—Otologicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/06—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
- C07C37/07—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
- C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71767805P | 2005-09-15 | 2005-09-15 | |
PCT/US2006/036052 WO2007035496A1 (en) | 2005-09-15 | 2006-09-15 | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
EP06814749.5A EP1933821B1 (en) | 2005-09-15 | 2006-09-15 | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1933821T1 true SI1933821T1 (sl) | 2020-11-30 |
Family
ID=37637229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200632388T SI1933821T1 (sl) | 2005-09-15 | 2006-09-15 | Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev |
Country Status (14)
Country | Link |
---|---|
US (1) | US7432305B2 (sl) |
EP (1) | EP1933821B1 (sl) |
JP (5) | JP2009508867A (sl) |
CA (1) | CA2622523C (sl) |
CY (1) | CY1123740T1 (sl) |
DK (1) | DK1933821T3 (sl) |
EA (1) | EA021818B1 (sl) |
ES (1) | ES2823728T3 (sl) |
HU (1) | HUE052377T2 (sl) |
LT (1) | LT1933821T (sl) |
PL (1) | PL1933821T3 (sl) |
PT (1) | PT1933821T (sl) |
SI (1) | SI1933821T1 (sl) |
WO (1) | WO2007035496A1 (sl) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
PT1888059E (pt) | 2005-06-01 | 2015-03-31 | Edison Pharmaceuticals Inc | Produtos terapêuticos com atividade redox para o tratamento de doenças mitocondriais e de outras condições e modulação de biomarcadores energéticos |
US9050005B2 (en) | 2005-08-25 | 2015-06-09 | Synapse Biomedical, Inc. | Method and apparatus for transgastric neurostimulation |
EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
EP1996284A2 (en) | 2006-03-09 | 2008-12-03 | Synapse Biomedical, Inc. | Ventilatory assist system and method to improve respiratory function |
US20080097153A1 (en) * | 2006-08-24 | 2008-04-24 | Ignagni Anthony R | Method and apparatus for grasping an abdominal wall |
US9079016B2 (en) * | 2007-02-05 | 2015-07-14 | Synapse Biomedical, Inc. | Removable intramuscular electrode |
WO2008144578A1 (en) * | 2007-05-17 | 2008-11-27 | Synapse Biomedical, Inc. | Devices and methods for assessing motor point electromyogram as a biomarker |
WO2009059033A1 (en) * | 2007-10-30 | 2009-05-07 | Synapse Biomedical, Inc. | Method of improving sleep disordered breathing |
US8428726B2 (en) | 2007-10-30 | 2013-04-23 | Synapse Biomedical, Inc. | Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system |
WO2009061744A2 (en) | 2007-11-06 | 2009-05-14 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
CA2708961C (en) * | 2008-01-08 | 2017-03-28 | Edison Pharmaceuticals, Inc. | (het)aryl-p-quinone derivatives for treatment of mitochondrial diseases |
EP2262508B1 (en) | 2008-03-05 | 2018-10-03 | BioElectron Technology Corporation | SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
EP2262519A4 (en) * | 2008-03-05 | 2011-03-23 | Edison Pharmaceuticals Inc | TREATMENT OF HEARING AND BALANCE DEFICIENCIES WITH THERAPEUTIC AGENTS WITH REDOX ACTIVITY |
EP2303824B1 (en) | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
BRPI0918139A2 (pt) * | 2008-09-10 | 2015-12-01 | Edison Pharmaceuticals Inc | composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos e uso |
US8263094B2 (en) * | 2008-09-23 | 2012-09-11 | Eastman Chemical Company | Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof |
WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
HUE041714T2 (hu) | 2008-10-28 | 2019-05-28 | Bioelectron Tech Corp | Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit |
HUE037574T2 (hu) | 2009-04-28 | 2018-09-28 | Bioelectron Tech Corp | Leber-féle örökletes optikus neuropátia és domináns optikus atrofia kezelése tokotrienol kinonokkal |
BR112012004167A2 (pt) * | 2009-08-26 | 2016-03-29 | Edison Pharmaceuticals Inc | métodos para a prevenção e o tratamento de isquemia cerebral |
JP6106158B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | 酸化的網膜疾患 |
EP2701695B1 (en) | 2011-04-26 | 2019-04-03 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating pufas |
AU2012249918B2 (en) | 2011-04-26 | 2017-06-15 | Biojiva Llc | Impaired energy processing disorders and mitochondrial deficiency |
AU2012249920B2 (en) | 2011-04-26 | 2017-06-15 | Biojiva Llc | Disorders implicating PUFA oxidation |
WO2012174286A1 (en) | 2011-06-14 | 2012-12-20 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
EP2734512B1 (en) | 2011-07-19 | 2019-11-20 | Bioelectron Technology Corporation | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
WO2014039917A1 (en) * | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ, インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
WO2015026708A2 (en) * | 2013-08-20 | 2015-02-26 | Wilson Robert B | Amelioration of the effects of friedriech's ataxia |
CA2941970A1 (en) | 2014-03-13 | 2015-09-17 | Retrotope, Inc. | Optic neuropathy treatment and reduction of steroid-induced oxidative stress with stabilized polyunsaturated substances |
SI3233786T1 (sl) | 2014-12-16 | 2022-08-31 | PTC Therapeutics, Inc., | Polimorfne in amorfne oblike (R)-2-hidroksi-2-metil-4-(2,4,5-trimetil- 3,6-dioksocikloheksa-1,4-dienil)butanamida |
EP3390377A1 (en) | 2015-12-16 | 2018-10-24 | BioElectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
WO2017106803A1 (en) * | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩 |
KR102580606B1 (ko) | 2016-11-17 | 2023-09-19 | 레트로토프 인코포레이티드 | 동위원소로 변형된 성분 및 이의 치료학적 용도 |
WO2018191732A1 (en) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Methods and compositions for treatment of inflammation and oxidative stress |
AU2019362010A1 (en) * | 2018-10-17 | 2021-05-20 | Ptc Therapeutics, Inc. | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating α-synucleinopathies, tauopathies, and other disorders |
US11471683B2 (en) | 2019-01-29 | 2022-10-18 | Synapse Biomedical, Inc. | Systems and methods for treating sleep apnea using neuromodulation |
KR20220078644A (ko) | 2019-10-04 | 2022-06-10 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 미토콘드리아 질환 치료를 위한 바티퀴논의 퀴논-, 히드로퀴논- 및 나프토퀴논-유사체 |
WO2021077034A1 (en) | 2019-10-18 | 2021-04-22 | Ptc Therapeutics, Inc. | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating hemoglobinopathy, thalassemia, sickle cell disease and other disorders |
KR20240032997A (ko) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물 |
WO2024050725A1 (en) * | 2022-09-07 | 2024-03-14 | Ptc Therapeutics, Inc. | Methods of producing 2, 3, 5, 6-alkyl-1, 4-benzoquinones |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2856414A (en) * | 1958-10-14 | Oxidation of alpha-tocopherol | ||
US2398418A (en) * | 1943-08-27 | 1946-04-16 | Louis F Fieser | Introduction of organic radicals into quinones |
FR1201200A (fr) | 1958-08-08 | 1959-12-29 | Sogespar S A | Procédé de fabrication de l'alpha tocophéryl-quinone |
US3071512A (en) * | 1959-01-26 | 1963-01-01 | Sogespar S A | New hypotensive pharmaceutical preparation containing alpha-tocopheryl-quinone |
US3406188A (en) * | 1964-03-27 | 1968-10-15 | Sun Oil Co | Preparation of alpha-tocopherylquinone |
FR5531M (sl) | 1966-02-08 | 1967-11-13 | ||
FR1536576A (fr) | 1967-08-29 | 1968-08-16 | Eastman Kodak Co | Procédés d'enrichissement et de fractionnement de mélanges à base de tocophérols |
US3728363A (en) * | 1970-03-17 | 1973-04-17 | Takeda Chemical Industries Ltd | Quinone derivatives |
US3705239A (en) * | 1970-10-16 | 1972-12-05 | Roy B Gregory | Pain removing compositions and methods |
UST917001I4 (en) * | 1971-12-02 | 1973-12-04 | Defensive publication | |
JPS5245698B2 (sl) * | 1973-04-06 | 1977-11-17 | ||
DE2431198A1 (de) * | 1973-07-02 | 1975-01-23 | Takeda Chemical Industries Ltd | Chinonderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzubereitungen |
US3909376A (en) * | 1974-12-04 | 1975-09-30 | Basf Ag | Electrolytic manufacture of alkyl-substituted hydroquinones |
US4153614A (en) * | 1978-05-12 | 1979-05-08 | Hoffmann-La Roche Inc. | Synthesis of (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol and intermediates therein |
LU77344A1 (sl) * | 1977-05-16 | 1979-01-19 | ||
US4201879A (en) * | 1977-05-16 | 1980-05-06 | Hoffmann-La Roche Inc. | Hydroquinones |
US4310465A (en) * | 1977-05-17 | 1982-01-12 | Hoffmann-La Roche Inc. | Synthesis of vitamin E and quinone intermediates |
US4127608A (en) * | 1977-05-17 | 1978-11-28 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
US4243598A (en) * | 1977-05-17 | 1981-01-06 | Hoffmann-La Roche Inc. | Synthesis of vitamin E |
US4185154A (en) * | 1977-05-17 | 1980-01-22 | Hoffmann-La Roche, Inc. | Synthesis of vitamin E |
US4201726A (en) * | 1977-05-17 | 1980-05-06 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
JPS5640651A (en) * | 1979-09-12 | 1981-04-16 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
JPS567734A (en) * | 1979-06-28 | 1981-01-27 | Takeda Chem Ind Ltd | Preparation of quinone derivative |
JPS56147746A (en) * | 1980-04-15 | 1981-11-16 | Takeda Chem Ind Ltd | Quinones and their preparation |
JPS567737A (en) * | 1979-07-02 | 1981-01-27 | Takeda Chem Ind Ltd | Physiologically active quinone and its preparation |
JPS5697223A (en) * | 1979-12-30 | 1981-08-05 | Takeda Chem Ind Ltd | Tissue metabolism activator |
JPH0193554A (ja) | 1980-04-07 | 1989-04-12 | Takeda Chem Ind Ltd | 有機化合物 |
JPS56140943A (en) | 1980-04-07 | 1981-11-04 | Takeda Chem Ind Ltd | Preparation of organic compound |
US4393075A (en) * | 1980-04-14 | 1983-07-12 | Takeda Chemical Industries, Ltd. | Quinone compounds and their use in suppressing the production of SRS-A in mammals |
JPS5750935A (en) | 1980-09-12 | 1982-03-25 | Otsuka Pharmaceut Co Ltd | 1,4-benzoquinone derivative |
JPS57131735A (en) * | 1981-02-09 | 1982-08-14 | Takeda Chem Ind Ltd | Preparation of quinones |
JPS5883698A (ja) | 1981-11-13 | 1983-05-19 | Takeda Chem Ind Ltd | キノン化合物およびその製造法 |
JPS58193689A (ja) | 1982-05-10 | 1983-11-11 | Shiseido Co Ltd | テストステロン−5α−レダクタ−ゼ阻害剤 |
CH655005A5 (it) * | 1983-02-16 | 1986-03-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica ad azione metabolica ed energetica utilizzabile in terapia cardiaca e vascolare. |
JPS59163316A (ja) * | 1983-03-08 | 1984-09-14 | Eisai Co Ltd | けいれんの治療・予防剤 |
JPS6028919A (ja) | 1983-07-28 | 1985-02-14 | Shiseido Co Ltd | 皮膚外用剤 |
EP0134198A1 (de) * | 1983-08-10 | 1985-03-13 | Ciba-Geigy Ag | Verwendung von Chinonderivaten zum Schützen von Kulturpflanzen vor der phytotoxischen Wirkung von Herbiziden |
US5304658A (en) * | 1984-08-01 | 1994-04-19 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
MX9203040A (es) * | 1984-08-01 | 1992-07-31 | Takeda Chemical Industries Ltd | Derivados de quinona y composicion farmaceutica que los contiene. |
JPS6140236A (ja) | 1984-08-02 | 1986-02-26 | Yamanouchi Pharmaceut Co Ltd | ハイドロキノン誘導体 |
US4592867A (en) * | 1984-10-19 | 1986-06-03 | Energy Conversion Devices, Inc. | Synthesis method for reductant precursor |
EP0183869B1 (en) * | 1984-12-06 | 1991-04-17 | Kuraray Co., Ltd. | Chroman compounds and their use |
US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
US5057514A (en) * | 1987-02-03 | 1991-10-15 | Suntory Limited | Compounds effective as cerebral schemia treating agents |
US5179092A (en) * | 1987-12-22 | 1993-01-12 | Suntory Limited | Compound effective as cerebral insufficiency improver |
US5288752A (en) * | 1987-12-22 | 1994-02-22 | Suntory Limited | Compound effective as cerebral insufficiency improver |
JPH01209445A (ja) | 1988-02-17 | 1989-08-23 | Fuji Photo Film Co Ltd | 放射線感応性材料 |
DE3818696C1 (en) | 1988-06-01 | 1989-03-30 | Ems-Inventa Ag, Zuerich, Ch | Process for the preparation of hydroquinone and its alkyl derivatives |
JPH08768B2 (ja) * | 1989-08-24 | 1996-01-10 | 武田薬品工業株式会社 | 神経成長因子分泌誘導剤 |
FI102273B (fi) * | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö |
JP3086284B2 (ja) | 1991-07-05 | 2000-09-11 | 京セラミタ株式会社 | 電子写真感光体 |
JP3859699B2 (ja) | 1992-05-28 | 2006-12-20 | センター・フォー・モレキュラー・バイオロジー・アンド・メディシン | 治療用組成物 |
CN1093360A (zh) | 1992-10-02 | 1994-10-12 | 武田药品工业株式会社 | 2-o-烷基抗坏血酸的锂盐 |
US5600029A (en) * | 1994-03-09 | 1997-02-04 | Takeda Chemical Industries, Ltd. | Process for producing DL-tocopherols and intermediates therefor |
EP0774967A1 (en) * | 1994-08-12 | 1997-05-28 | Takeda Chemical Industries, Ltd. | Use of quinone and hydroquinone derivatives for the teatment of cachexia |
US6150402A (en) * | 1994-08-15 | 2000-11-21 | Loma Linda University Medical Center | Natriuretic compounds |
JPH0892151A (ja) | 1994-09-29 | 1996-04-09 | Sagami Chem Res Center | アリルキノンの製造方法 |
US5547827A (en) * | 1994-12-22 | 1996-08-20 | Eastman Kodak Company | Iodochloride emulsions containing quinones having high sensitivity and low fog |
EP0719552A3 (en) | 1994-12-26 | 1997-08-20 | Takeda Chemical Industries Ltd | Pharmaceutical composition containing a quinone derivative or the hydroquinone thereof for the treatment of dermatitis |
US6011046A (en) * | 1995-08-21 | 2000-01-04 | Takeda Chemical Industries, Ltd. | Quinone compound, its production and use as antioxidant |
US5846988A (en) * | 1996-03-25 | 1998-12-08 | Alcon Laboratories, Inc. | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
AU3458997A (en) * | 1996-07-11 | 1998-02-09 | Takeda Chemical Industries Ltd. | Anti-beta-amyloid protein-induced cytotoxicity composition |
GB9702310D0 (en) | 1997-02-05 | 1997-03-26 | Univ Hertfordshire | Invention |
GB9722361D0 (en) * | 1997-10-24 | 1997-12-17 | Pharma Nord Uk Ltd | Pharmaceutical formulation for treating liver disorders |
US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
US6433199B1 (en) * | 1998-05-22 | 2002-08-13 | Shionogi Bioresearch Corporation | Quinone derivatives |
US5969133A (en) * | 1998-05-22 | 1999-10-19 | Shiongi Bioresearch Corp. | Bioreductive cytotoxic agents |
KR20010072080A (ko) * | 1998-07-31 | 2001-07-31 | 쓰끼하시 다미까따 | 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제 |
IT1304406B1 (it) * | 1998-10-21 | 2001-03-19 | Danital Italia S R L | Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3. |
CA2272971C (en) * | 1998-10-29 | 2008-01-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
JP2000202297A (ja) | 1999-01-20 | 2000-07-25 | Chemiprokasei Kaisha Ltd | 新規な酸化反応用触媒およびそれを用いたp―ベンゾキノン類の製造方法 |
AU776437B2 (en) | 1999-02-23 | 2004-09-09 | Regents Of The University Of California, The | Methods of treatment of mitochondrial disorders |
US6045826A (en) * | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6632443B2 (en) * | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
DE19916801A1 (de) | 1999-04-14 | 2000-11-02 | Bosch Gmbh Robert | Spritzdüse für eine Scheibenwaschanlage |
US6426362B1 (en) * | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
US8753675B1 (en) | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
US6740338B1 (en) * | 2000-01-20 | 2004-05-25 | Raj K. Chopra | Reduced form of Cenzyme Q in high bioavailability stable oral dosage form |
WO2001092215A2 (en) | 2000-06-02 | 2001-12-06 | Us Health | Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same |
DE10034233A1 (de) * | 2000-07-14 | 2002-01-24 | Basf Ag | Tocotrienolchinon-Cyclisierungsprodukte |
US6545184B1 (en) * | 2000-08-15 | 2003-04-08 | The Regents Of The University Of California | Practical, cost-effective synthesis of COQ10 |
US6300377B1 (en) * | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
US6764768B2 (en) * | 2001-02-28 | 2004-07-20 | Arch Development Corporation | Controlled release composition |
US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
JP2003064017A (ja) | 2001-06-12 | 2003-03-05 | Hokko Chem Ind Co Ltd | オキシスチレン誘導体の蒸留方法 |
US7172905B2 (en) * | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
NZ513547A (en) * | 2001-08-13 | 2002-09-27 | Antipodean Biotechnology Ltd | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
JP2003137716A (ja) | 2001-10-30 | 2003-05-14 | Eau De Faveur:Kk | 皮膚の外用剤 |
ATE328283T1 (de) * | 2002-07-01 | 2006-06-15 | Santhera Pharmaceuticals Ch | Screeningverfahren und verbindungen zur behandlung von friedreich ataxia |
US6953331B2 (en) * | 2002-08-30 | 2005-10-11 | Extreme Components L.P. | Positioning device with bearing mechanism |
CA2580584C (en) * | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
US7022441B2 (en) * | 2004-02-25 | 2006-04-04 | Eastman Kodak Company | Silver-free black-and-white thermographic materials containing a benzoquinone and methods of imaging |
DE102004032837A1 (de) * | 2004-07-02 | 2006-02-09 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus einem oder mehreren Biochinonen und einem oder mehreren Isoflavonen zur Verbesserung der Hautkonturen |
PT1888059E (pt) * | 2005-06-01 | 2015-03-31 | Edison Pharmaceuticals Inc | Produtos terapêuticos com atividade redox para o tratamento de doenças mitocondriais e de outras condições e modulação de biomarcadores energéticos |
-
2006
- 2006-09-15 PT PT68147495T patent/PT1933821T/pt unknown
- 2006-09-15 EA EA200800819A patent/EA021818B1/ru not_active IP Right Cessation
- 2006-09-15 LT LTEP06814749.5T patent/LT1933821T/lt unknown
- 2006-09-15 CA CA2622523A patent/CA2622523C/en active Active
- 2006-09-15 PL PL06814749T patent/PL1933821T3/pl unknown
- 2006-09-15 US US11/521,887 patent/US7432305B2/en active Active
- 2006-09-15 JP JP2008531360A patent/JP2009508867A/ja not_active Withdrawn
- 2006-09-15 EP EP06814749.5A patent/EP1933821B1/en active Active
- 2006-09-15 HU HUE06814749A patent/HUE052377T2/hu unknown
- 2006-09-15 WO PCT/US2006/036052 patent/WO2007035496A1/en active Application Filing
- 2006-09-15 SI SI200632388T patent/SI1933821T1/sl unknown
- 2006-09-15 ES ES06814749T patent/ES2823728T3/es active Active
- 2006-09-15 DK DK06814749.5T patent/DK1933821T3/da active
-
2013
- 2013-05-08 JP JP2013098528A patent/JP5999816B2/ja active Active
-
2014
- 2014-12-17 JP JP2014254928A patent/JP2015078224A/ja not_active Withdrawn
-
2015
- 2015-11-16 JP JP2015223653A patent/JP2016040311A/ja active Pending
-
2017
- 2017-07-03 JP JP2017130267A patent/JP2017193570A/ja not_active Withdrawn
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Also Published As
Publication number | Publication date |
---|---|
JP2013155194A (ja) | 2013-08-15 |
JP2015078224A (ja) | 2015-04-23 |
JP2009508867A (ja) | 2009-03-05 |
US7432305B2 (en) | 2008-10-07 |
CY1123740T1 (el) | 2022-03-24 |
EP1933821A1 (en) | 2008-06-25 |
JP2016040311A (ja) | 2016-03-24 |
WO2007035496A1 (en) | 2007-03-29 |
PT1933821T (pt) | 2020-10-15 |
HUE052377T2 (hu) | 2021-04-28 |
LT1933821T (lt) | 2020-11-10 |
US20070072943A1 (en) | 2007-03-29 |
CA2622523C (en) | 2014-02-18 |
JP2017193570A (ja) | 2017-10-26 |
PL1933821T3 (pl) | 2021-01-11 |
ES2823728T3 (es) | 2021-05-10 |
EA021818B1 (ru) | 2015-09-30 |
DK1933821T3 (da) | 2020-10-26 |
EP1933821B1 (en) | 2020-07-29 |
JP5999816B2 (ja) | 2016-09-28 |
EA200800819A1 (ru) | 2008-08-29 |
CA2622523A1 (en) | 2007-03-29 |
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