HUE041714T2 - Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit - Google Patents
Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereitInfo
- Publication number
- HUE041714T2 HUE041714T2 HUE15175938A HUE15175938A HUE041714T2 HU E041714 T2 HUE041714 T2 HU E041714T2 HU E15175938 A HUE15175938 A HU E15175938A HU E15175938 A HUE15175938 A HU E15175938A HU E041714 T2 HUE041714 T2 HU E041714T2
- Authority
- HU
- Hungary
- Prior art keywords
- intermediates
- composition containing
- containing alpha
- tocotrienol quinone
- tocotrienol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE041714T2 true HUE041714T2 (hu) | 2019-05-28 |
Family
ID=42118126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE15175938A HUE041714T2 (hu) | 2008-10-28 | 2009-10-27 | Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (hu) |
| EP (3) | EP3450431B1 (hu) |
| JP (7) | JP5775459B2 (hu) |
| CN (2) | CN105753829B (hu) |
| BR (1) | BRPI0920414B1 (hu) |
| CA (2) | CA2741767C (hu) |
| DK (2) | DK2963006T3 (hu) |
| EA (2) | EA201692046A1 (hu) |
| ES (2) | ES2553557T3 (hu) |
| HK (2) | HK1161876A1 (hu) |
| HU (1) | HUE041714T2 (hu) |
| MX (1) | MX2011004440A (hu) |
| MY (2) | MY157119A (hu) |
| PL (2) | PL2362875T3 (hu) |
| PT (2) | PT2362875E (hu) |
| SI (1) | SI2963006T1 (hu) |
| TR (1) | TR201819154T4 (hu) |
| WO (1) | WO2010051277A1 (hu) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065099A1 (en) | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
| EP2564843B1 (en) | 2005-06-01 | 2018-12-26 | Bioelectron Technology Corporation | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2704473C (en) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| WO2009089224A1 (en) * | 2008-01-08 | 2009-07-16 | Edison Pharmaceuticals, Inc. | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES |
| JP5710277B2 (ja) | 2008-03-05 | 2015-04-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体 |
| EP2303824B1 (en) * | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| JP2012502064A (ja) | 2008-09-10 | 2012-01-26 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| WO2010051277A1 (en) * | 2008-10-28 | 2010-05-06 | Edison Pharmaceuticals, Inc. | Process for the production of alpha-tocotrienol and derivatives |
| BRPI1013376A8 (pt) | 2009-04-28 | 2017-07-11 | Edison Pharmaceuticals Inc | Uso de quinonas de tocotrienol,preparação farmacêutica compreendendo as ditas quinonas e uso desta |
| MX337990B (es) * | 2009-08-26 | 2016-03-30 | Edison Pharmaceuticals Inc | Metodos para la prevencion y tratamiento de isquemia cerebral. |
| WO2012154613A1 (en) * | 2011-05-06 | 2012-11-15 | Edison Pharmaceuticals, Inc. | Improved process for the preparation of d-alpha-tocotrienol from natural extracts |
| EP2720689A4 (en) | 2011-06-14 | 2014-11-26 | Edison Pharmaceuticals Inc | CATÉCHOL DERIVATIVES FOR THE TREATMENT OF OXIDATIVE STRESS DISEASES |
| WO2013013078A1 (en) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| MY162508A (en) * | 2011-07-21 | 2017-06-15 | Sime Darby Malaysia Berhad | External preparation for skin |
| CA2883882A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| US8937191B2 (en) * | 2012-12-20 | 2015-01-20 | Orochem Technologies, Inc. | Recovery of highly pure alpha-tocotrienol from crude palm oil extract |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| CN106414580A (zh) * | 2013-11-29 | 2017-02-15 | 沙特基础工业公司 | 稳定化的聚烯烃组合物 |
| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| CN104262315A (zh) * | 2014-09-05 | 2015-01-07 | 宁波大红鹰生物工程股份有限公司 | 一种生育三烯酚的分离提纯方法 |
| ES2912585T3 (es) | 2014-12-16 | 2022-05-26 | Ptc Therapeutics Inc | Formas polimórficas y amorfas de la (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida |
| JP2018502127A (ja) | 2015-01-12 | 2018-01-25 | バイオエレクトロン テクノロジー コーポレイション | 放射線被曝に対する防護のためのキノン |
| JP7117241B2 (ja) * | 2015-12-16 | 2022-08-12 | ピーティーシー セラピューティクス， インコーポレイテッド | 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法 |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| CA3011293A1 (en) | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| WO2018191732A1 (en) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Methods and compositions for treatment of inflammation and oxidative stress |
| DK3866772T3 (da) | 2018-10-17 | 2024-01-15 | Ptc Therapeutics Inc | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-dien-1,4-dion til undertrykkelse og behandling af alpha-synucleinopathier, tauopathier og andre lidelser |
| WO2021067836A1 (en) | 2019-10-04 | 2021-04-08 | Stealth Biotherapeutics Corp | Chinone-, hydrochinome- and naphthochinone-analogues of vatiquione for treatment of mitochondrial disorder diseases |
| EP4126836A1 (en) | 2020-04-03 | 2023-02-08 | Stealth BioTherapeutics Inc. | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including friedreich's ataxia |
| KR20240032997A (ko) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2519863A (en) | 1949-05-14 | 1950-08-22 | Eastman Kodak Co | Conversion of beta-, gamma-, and delta-tocopherol to alpha-tocopherol by aminoalkylation and reduction |
| AU581216B2 (en) * | 1984-04-17 | 1989-02-16 | Henkel Corporation | Production of d-alpha-tocopherol from natural plant sources |
| US4977282A (en) * | 1984-04-17 | 1990-12-11 | Henkel Corporation | Production of d-alpha-tocopherol from natural plant sources |
| US4603142A (en) | 1984-06-01 | 1986-07-29 | Wisconsin Alumni Research Foundation | Cholesterol lowering method of use |
| JPS636186A (ja) | 1986-06-23 | 1988-01-12 | タツタ電線株式会社 | 点滴監視装置 |
| JPH0788376B2 (ja) | 1986-09-02 | 1995-09-27 | エーザイ株式会社 | 光学活性α−トコトリエノ−ルの製造方法 |
| JP2685785B2 (ja) | 1988-03-11 | 1997-12-03 | エーザイ株式会社 | 光学活性α−トコトリエノールの製造方法 |
| EP0333472B1 (en) | 1988-03-16 | 1997-10-08 | PALM OIL RESEARCH & DEVELOPMENT BOARD | Production of high concentration tocopherols and tocotrienols from palm oil by-products |
| US5157132A (en) | 1990-05-18 | 1992-10-20 | Carotech Associates | Integrated process for recovery of carotenoids and tocotrienols from oil |
| JPH07504887A (ja) | 1991-11-22 | 1995-06-01 | リポジェニックス，インコーポレイテッド | トコトリエノールおよびトコトリエノール様化合物ならびにこれらを使用する方法 |
| EP0735033B1 (de) * | 1995-03-28 | 2000-07-12 | F. Hoffmann-La Roche Ag | Aminomethylierung von Tocopherolen |
| US5660691A (en) | 1995-11-13 | 1997-08-26 | Eastman Chemical Company | Process for the production of tocotrienol/tocopherol blend concentrates |
| US6232060B1 (en) | 1996-01-19 | 2001-05-15 | Galileo Laboratories, Inc. | Assay system for anti-stress agents |
| US5801159A (en) | 1996-02-23 | 1998-09-01 | Galileo Laboratories, Inc. | Method and composition for inhibiting cellular irreversible changes due to stress |
| US5932748A (en) | 1997-06-06 | 1999-08-03 | Roche Vitamins Inc. | Process for permethylating non-α-tocopherols to produce α-tocopherol |
| SK283682B6 (sk) * | 1997-10-29 | 2003-11-04 | Flexsys America L. P. | Spôsob prípravy chinóndiimínu |
| BR9907278A (pt) | 1998-01-29 | 2000-10-24 | Eastman Chem Co | Processos para separar um tocotrienol de uma primeira mistura de tocol, e, composição |
| DE69939457D1 (de) * | 1998-11-06 | 2008-10-16 | Fuji Chem Ind Co Ltd | Tocotrienole enthaltende pulver und tabletten hergestellt durch formpressen dieser pulver |
| US6395915B1 (en) | 1999-09-10 | 2002-05-28 | Technikrom, Inc. | Method for producing purified tocotrienols and tocopherols using liquid chromatography |
| MY127451A (en) | 1999-11-04 | 2006-12-29 | Malaysian Palm Oil Board | A method of chromatographic isolation for vitamin e isomers |
| DE10034233A1 (de) * | 2000-07-14 | 2002-01-24 | Basf Ag | Tocotrienolchinon-Cyclisierungsprodukte |
| US7034054B2 (en) | 2000-12-15 | 2006-04-25 | Galileo Pharmaceuticals, Inc. | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols |
| US6838104B2 (en) | 2000-12-20 | 2005-01-04 | Archer Daniels Midland Company | Process for the production of tocotrienols |
| US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
| JP4842455B2 (ja) | 2001-06-13 | 2011-12-21 | コマツＮｔｃ株式会社 | 半導体単結晶引上げ装置及びそのライン構成 |
| JP2003171376A (ja) | 2001-09-27 | 2003-06-20 | Lion Corp | トコフェロール類及びトコトリエノール類濃縮物、その製造方法 |
| US6667330B2 (en) | 2002-01-31 | 2003-12-23 | Galileo Pharmaceuticals, Inc. | Furanone derivatives |
| US6653346B1 (en) | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| US6590113B1 (en) | 2002-03-26 | 2003-07-08 | Ronald T. Sleeter | Process for treating oils containing antioxidant compounds |
| AU2003287250B9 (en) | 2002-10-30 | 2010-01-28 | Ptc Therapeutics, Inc. | Identifying therapeutic compounds based on their physical-chemical properties |
| MY130618A (en) | 2002-11-27 | 2007-07-31 | Malaysian Palm Oil Board | A method of extracting and isolating minor components from vegetable oil |
| US20050065099A1 (en) | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
| WO2005035490A2 (en) | 2003-10-10 | 2005-04-21 | Yasoo Health, Inc. | PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS |
| MY173044A (en) | 2003-11-19 | 2019-12-20 | Carotech Bhd | Recovery of phytonutriens from oils |
| US7393662B2 (en) | 2004-09-03 | 2008-07-01 | Centocor, Inc. | Human EPO mimetic hinge core mimetibodies, compositions, methods and uses |
| EP2564843B1 (en) * | 2005-06-01 | 2018-12-26 | Bioelectron Technology Corporation | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| LT1933821T (lt) | 2005-09-15 | 2020-11-10 | Ptc Therapeutics, Inc. | Šoninės grandinės variantai redoks aktyviųjų terapijos priemonių, skirtų mitochondrinių ligų ir kitokių būklių gydymui ir energijos biologinių žymenų moduliavimui |
| US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| WO2007105297A1 (ja) * | 2006-03-13 | 2007-09-20 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | メチン系色素とその用途 |
| WO2008086025A2 (en) | 2007-01-10 | 2008-07-17 | Edison Pharmaceuticals, Inc. | Treatment of respiratory chain disorders using compounds having erythropoietin or thrombopoietin activity |
| WO2008142433A1 (en) | 2007-05-24 | 2008-11-27 | Loders Croklaan B.V. | Process for producing compositions comprising tocoherols and tocotrienols |
| CA2704473C (en) | 2007-11-06 | 2016-10-04 | Edison Pharmaceuticals, Inc. | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| CA2710253A1 (en) | 2008-01-07 | 2009-07-16 | Centocor Ortho Biotech Inc. | Method of treating erythropoietin hyporesponsive anemias |
| WO2009089224A1 (en) | 2008-01-08 | 2009-07-16 | Edison Pharmaceuticals, Inc. | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES |
| CA2717741C (en) | 2008-03-05 | 2018-04-03 | Edison Pharmaceuticals, Inc. | Treatment of hearing and balance impairments with redox-active therapeutics |
| JP5710277B2 (ja) | 2008-03-05 | 2015-04-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体 |
| US20110142834A1 (en) | 2008-05-15 | 2011-06-16 | Edison Pharmaceuticals, Inc. | Treatment of hearing and balance impairments using compounds having erythropoietin activity |
| MX2010012486A (es) | 2008-05-22 | 2010-12-02 | Edison Pharmaceuticals Inc | Tratamiento de enfermedades mitocondriales con un mimetico de eritropoyetina. |
| EP2303824B1 (en) | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| US20100010100A1 (en) | 2008-07-09 | 2010-01-14 | Hinman Andrew W | Dermatological compositions with anti-aging and skin even-toning properties |
| WO2010014758A1 (en) | 2008-07-30 | 2010-02-04 | Edison Pharmaceuticals, Inc. | Use of hydrogenated pyrido[4,3-b] indoles for the treatment of oxidative stress |
| US20100029784A1 (en) | 2008-07-30 | 2010-02-04 | Hinman Andrew W | Naphthoquinone compositions with anti-aging, anti-inflammatory and skin even-toning properties |
| JP2012502064A (ja) | 2008-09-10 | 2012-01-26 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| WO2010051277A1 (en) * | 2008-10-28 | 2010-05-06 | Edison Pharmaceuticals, Inc. | Process for the production of alpha-tocotrienol and derivatives |
| BRPI1013376A8 (pt) | 2009-04-28 | 2017-07-11 | Edison Pharmaceuticals Inc | Uso de quinonas de tocotrienol,preparação farmacêutica compreendendo as ditas quinonas e uso desta |
| JP2012525397A (ja) | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ， インコーポレイテッド | 眼科疾患を治療するためのトコトリエノールキノンの製剤 |
| BRPI1015006A2 (pt) | 2009-04-28 | 2019-09-24 | Ampere Life Sciences Inc | uso tópico, periocular, ou intraocular de tocotrienóis para o tratamento de doenças oftálmicas |
| CA2765771A1 (en) | 2009-06-25 | 2010-12-29 | Ampere Life Sciences, Inc. | Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts |
| MX337990B (es) | 2009-08-26 | 2016-03-30 | Edison Pharmaceuticals Inc | Metodos para la prevencion y tratamiento de isquemia cerebral. |
| US20110172312A1 (en) | 2009-12-31 | 2011-07-14 | Miller Guy M | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| CA2792520A1 (en) | 2010-03-09 | 2011-09-15 | Edison Pharmaceuticals, Inc. | Synthesis of alpha-tocopherolquinone derivatives, and methods of using the same |
| WO2011113018A1 (en) | 2010-03-12 | 2011-09-15 | Ampere Life Sciences, Inc. | Measurement and control of biological time |
| CA2795726A1 (en) | 2010-04-06 | 2011-10-13 | Edison Pharmaceuticals, Inc. | Treatment of ataxia telangiectasia |
| EA201201465A1 (ru) | 2010-04-27 | 2013-04-30 | Эдисон Фармасьютикалз, Инк. | Лекарственные формы хинонов для лечения офтальмических заболеваний |
| WO2012009271A1 (en) | 2010-07-14 | 2012-01-19 | Penwest Pharmaceuticals Co. | Methods of providing anticoagulation effects in subjects |
| MX2013001469A (es) | 2010-08-06 | 2013-05-14 | Edison Pharmaceuticals Inc | Tratamiento de enfermedades mitocondriales con naftoquinonas |
| WO2012068552A1 (en) | 2010-11-19 | 2012-05-24 | Edison Pharmaceuticals, Inc. | Methods for improving blood glucose control |
| WO2012154613A1 (en) | 2011-05-06 | 2012-11-15 | Edison Pharmaceuticals, Inc. | Improved process for the preparation of d-alpha-tocotrienol from natural extracts |
| WO2012170773A1 (en) | 2011-06-08 | 2012-12-13 | Edison Pharmaceuticals, Inc. | Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones |
| EP2720689A4 (en) | 2011-06-14 | 2014-11-26 | Edison Pharmaceuticals Inc | CATÉCHOL DERIVATIVES FOR THE TREATMENT OF OXIDATIVE STRESS DISEASES |
| WO2013006736A1 (en) | 2011-07-06 | 2013-01-10 | Edison Pharmaceuticals, Inc | Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones |
| ES2795798T3 (es) | 2011-07-06 | 2020-11-24 | Ptc Therapeutics Inc | Tratamiento de aciduria metilmalónica, aciduria isovalérica, y otras acidurias orgánicas con tocotrienol quinonas |
| WO2013013078A1 (en) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| CA2883882A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| US8937191B2 (en) | 2012-12-20 | 2015-01-20 | Orochem Technologies, Inc. | Recovery of highly pure alpha-tocotrienol from crude palm oil extract |
| CA2902506A1 (en) | 2013-03-08 | 2014-09-12 | Unilever Plc | Resorcinol compounds for dermatological use |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US20140275045A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| WO2014194292A1 (en) | 2013-05-31 | 2014-12-04 | Edison Pharmaceuticals, Inc. | Carboxylic acid derivatives for treatment of oxidative stress disorders |
| ES2912585T3 (es) | 2014-12-16 | 2022-05-26 | Ptc Therapeutics Inc | Formas polimórficas y amorfas de la (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida |
| EP3233819A1 (en) | 2014-12-16 | 2017-10-25 | Bioelectron Technology Corporation | Methods for chiral resolution of trolox |
| JP2018502127A (ja) | 2015-01-12 | 2018-01-25 | バイオエレクトロン テクノロジー コーポレイション | 放射線被曝に対する防護のためのキノン |
| JP7117241B2 (ja) | 2015-12-16 | 2022-08-12 | ピーティーシー セラピューティクス， インコーポレイテッド | 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法 |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| CA3011293A1 (en) | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels |
| WO2017123823A1 (en) | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Alkyl-, acyl-, urea-, and aza-uracil sulfide:quinone oxidoreductase inhibitors |
| US20190241497A1 (en) | 2016-10-28 | 2019-08-08 | Andrew W. Hinman | Methods for analyzing p-hydroquinone levels and ratios |
| WO2018093957A1 (en) | 2016-11-15 | 2018-05-24 | Bioelectron Technology Corporation | 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications |
| WO2018129411A1 (en) | 2017-01-06 | 2018-07-12 | Bioelectron Technology Corporation | Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders |
| WO2018191732A1 (en) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Methods and compositions for treatment of inflammation and oxidative stress |
-
2009
- 2009-10-27 WO PCT/US2009/062212 patent/WO2010051277A1/en active Application Filing
- 2009-10-27 ES ES09824070.8T patent/ES2553557T3/es active Active
- 2009-10-27 CN CN201610142967.2A patent/CN105753829B/zh active Active
- 2009-10-27 DK DK15175938.8T patent/DK2963006T3/en active
- 2009-10-27 EP EP18200523.1A patent/EP3450431B1/en active Active
- 2009-10-27 BR BRPI0920414-8A patent/BRPI0920414B1/pt active IP Right Grant
- 2009-10-27 EP EP09824070.8A patent/EP2362875B1/en active Active
- 2009-10-27 MX MX2011004440A patent/MX2011004440A/es active IP Right Grant
- 2009-10-27 SI SI200931894T patent/SI2963006T1/sl unknown
- 2009-10-27 ES ES15175938T patent/ES2701260T3/es active Active
- 2009-10-27 CA CA2741767A patent/CA2741767C/en active Active
- 2009-10-27 PT PT98240708T patent/PT2362875E/pt unknown
- 2009-10-27 HU HUE15175938A patent/HUE041714T2/hu unknown
- 2009-10-27 MY MYPI2011001873A patent/MY157119A/en unknown
- 2009-10-27 EA EA201692046A patent/EA201692046A1/ru unknown
- 2009-10-27 DK DK09824070.8T patent/DK2362875T3/en active
- 2009-10-27 TR TR2018/19154T patent/TR201819154T4/tr unknown
- 2009-10-27 MY MYPI2014003438A patent/MY185183A/en unknown
- 2009-10-27 CA CA2974482A patent/CA2974482C/en active Active
- 2009-10-27 PL PL09824070T patent/PL2362875T3/pl unknown
- 2009-10-27 EP EP15175938.8A patent/EP2963006B1/en active Active
- 2009-10-27 CN CN200980152635.0A patent/CN102264730B/zh active Active
- 2009-10-27 US US12/606,923 patent/US8106223B2/en active Active
- 2009-10-27 PT PT15175938T patent/PT2963006T/pt unknown
- 2009-10-27 EA EA201100699A patent/EA026417B1/ru not_active IP Right Cessation
- 2009-10-27 JP JP2011534678A patent/JP5775459B2/ja active Active
- 2009-10-27 PL PL15175938T patent/PL2963006T3/pl unknown
-
2012
- 2012-01-25 US US13/358,451 patent/US8575369B2/en active Active
- 2012-02-23 HK HK12101813.9A patent/HK1161876A1/xx unknown
-
2013
- 2013-09-26 US US14/038,675 patent/US20140221674A1/en not_active Abandoned
-
2014
- 2014-09-02 JP JP2014177733A patent/JP6001025B2/ja active Active
-
2015
- 2015-07-14 JP JP2015140302A patent/JP2015187169A/ja not_active Withdrawn
-
2016
- 2016-03-11 US US15/068,452 patent/US10071978B2/en active Active
- 2016-07-04 HK HK16107746.4A patent/HK1219718A1/zh unknown
-
2018
- 2018-06-06 JP JP2018108448A patent/JP7181708B2/ja active Active
- 2018-09-10 US US16/127,102 patent/US11312697B2/en active Active
-
2019
- 2019-01-22 JP JP2019008496A patent/JP2019065041A/ja not_active Withdrawn
-
2021
- 2021-02-04 JP JP2021016310A patent/JP2021066745A/ja not_active Withdrawn
-
2022
- 2022-03-18 US US17/699,061 patent/US20220204469A1/en active Pending
-
2023
- 2023-03-31 JP JP2023057343A patent/JP2023073469A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2963006T1 (sl) | Sestavek vsebujoč alfa-tokotrienol kinon in njegove vmesne povezave | |
| IL239833A0 (en) | Iminothiadiazine dioxide compounds, their preparations and uses | |
| HK1222645A1 (zh) | 對映體富集的芳基並吡咯- -基氰基乙基氨基殺寄生蟲化合物 | |
| HK1194071A1 (en) | Certain triazolopyrazines, compositions thereof and methods of use therefor | |
| IL215684A0 (en) | Trehalulose-containing composition, its preparation and use | |
| EP2445067A4 (en) | COMPOSITION FOR FILLING THE DISCHARGE GAP AND ELECTROSTATIC DISCHARGE PROTECTION | |
| EP2236149A4 (en) | MEDICAL COMPOSITION | |
| EP2351732A4 (en) | NEW RAMALINE CONNECTION AND ITS USE | |
| IL216388A0 (en) | New compounds, pharmaceutical composition and methods relating thereto | |
| PL2128199T3 (pl) | Nowa kompozycja | |
| HK1160231A1 (en) | Carabiner glasses | |
| GB0806978D0 (en) | Novel formulations | |
| HRP20160578T1 (hr) | Supstituirani furankarboksamidi i njihova upotreba | |
| HRP20150021T1 (en) | Phenanthrenone compounds, compositions and methods | |
| GB0801122D0 (en) | Vaccine composition | |
| GB0901234D0 (en) | Composition,method and use | |
| GB0901227D0 (en) | Composition,method and use | |
| GB0901293D0 (en) | Composition, method and use | |
| GB0819465D0 (en) | Multiparticulate composition | |
| GB0809774D0 (en) | New use | |
| GB0814881D0 (en) | New threapeutic use | |
| GB0814882D0 (en) | New threapeutic use | |
| GB0807591D0 (en) | New use | |
| GB0817379D0 (en) | New use | |
| GB0813121D0 (en) | Novel formulations |