BRPI0920414A2 - Processo para a produção de alfa-tocotrienal e seus derivados - Google Patents
Processo para a produção de alfa-tocotrienal e seus derivadosInfo
- Publication number
- BRPI0920414A2 BRPI0920414A2 BRPI0920414-8A BRPI0920414A BRPI0920414A2 BR PI0920414 A2 BRPI0920414 A2 BR PI0920414A2 BR PI0920414 A BRPI0920414 A BR PI0920414A BR PI0920414 A2 BRPI0920414 A2 BR PI0920414A2
- Authority
- BR
- Brazil
- Prior art keywords
- tocotrienal
- alpha
- derivatives
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 | |
| US61/197,585 | 2008-10-28 | ||
| PCT/US2009/062212 WO2010051277A1 (en) | 2008-10-28 | 2009-10-27 | Process for the production of alpha-tocotrienol and derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0920414A2 true BRPI0920414A2 (pt) | 2015-08-04 |
| BRPI0920414B1 BRPI0920414B1 (pt) | 2018-05-22 |
Family
ID=42118126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0920414-8A BRPI0920414B1 (pt) | 2008-10-28 | 2009-10-27 | Processo para a produção, o enriquecimento e/ou o isolamento do alfa-tocotrienol a partir de um material de planta que compreende alfa- tocotrienol e pelo menos um não-alfa tocotrienol |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (pt) |
| EP (3) | EP2963006B1 (pt) |
| JP (7) | JP5775459B2 (pt) |
| CN (2) | CN105753829B (pt) |
| BR (1) | BRPI0920414B1 (pt) |
| CA (2) | CA2741767C (pt) |
| DK (2) | DK2362875T3 (pt) |
| EA (2) | EA201692046A1 (pt) |
| ES (2) | ES2553557T3 (pt) |
| HK (2) | HK1161876A1 (pt) |
| HU (1) | HUE041714T2 (pt) |
| MX (1) | MX2011004440A (pt) |
| MY (2) | MY185183A (pt) |
| PL (2) | PL2963006T3 (pt) |
| PT (2) | PT2362875E (pt) |
| SI (1) | SI2963006T1 (pt) |
| TR (1) | TR201819154T4 (pt) |
| WO (1) | WO2010051277A1 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514461B2 (en) | 2003-09-19 | 2009-04-07 | Edison Pharmaceuticals, Inc. | Chroman derivatives |
| DK1888059T3 (en) * | 2005-06-01 | 2015-03-30 | Edison Pharmaceuticals Inc | Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| EP2220030B1 (en) | 2007-11-06 | 2016-01-13 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| WO2009089224A1 (en) | 2008-01-08 | 2009-07-16 | Edison Pharmaceuticals, Inc. | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| US8716486B2 (en) * | 2008-06-25 | 2014-05-06 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| US8314153B2 (en) | 2008-09-10 | 2012-11-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
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| PL2963006T3 (pl) | 2008-10-28 | 2019-01-31 | Bioelectron Technology Corporation | Kompozycja zawierająca chinon alfa-tokotrienolu, i jego związki pośrednie |
| NO2424495T3 (pt) | 2009-04-28 | 2018-06-16 | ||
| NO2470168T3 (pt) * | 2009-08-26 | 2018-06-30 | ||
| WO2012154613A1 (en) * | 2011-05-06 | 2012-11-15 | Edison Pharmaceuticals, Inc. | Improved process for the preparation of d-alpha-tocotrienol from natural extracts |
| US9464016B2 (en) | 2011-06-14 | 2016-10-11 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| EP2734512B1 (en) | 2011-07-19 | 2019-11-20 | Bioelectron Technology Corporation | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| MY162508A (en) * | 2011-07-21 | 2017-06-15 | Sime Darby Malaysia Berhad | External preparation for skin |
| CA2883882A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| US8937191B2 (en) * | 2012-12-20 | 2015-01-20 | Orochem Technologies, Inc. | Recovery of highly pure alpha-tocotrienol from crude palm oil extract |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| EP2970158B1 (en) | 2013-03-15 | 2019-02-20 | BioElectron Technology Corporation | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
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| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| CN104262315A (zh) * | 2014-09-05 | 2015-01-07 | 宁波大红鹰生物工程股份有限公司 | 一种生育三烯酚的分离提纯方法 |
| SI3233786T1 (sl) | 2014-12-16 | 2022-08-31 | PTC Therapeutics, Inc., | Polimorfne in amorfne oblike (R)-2-hidroksi-2-metil-4-(2,4,5-trimetil- 3,6-dioksocikloheksa-1,4-dienil)butanamida |
| JP2018502127A (ja) | 2015-01-12 | 2018-01-25 | バイオエレクトロン テクノロジー コーポレイション | 放射線被曝に対する防護のためのキノン |
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| WO2017123820A1 (en) | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Methods for diagnosing and treating oxidative stress disorders using biomarkers |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| WO2018191732A1 (en) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Methods and compositions for treatment of inflammation and oxidative stress |
| JP2022505257A (ja) | 2018-10-17 | 2022-01-14 | ピーティーシー セラピューティクス， インコーポレイテッド | α－シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための２，３，５－トリメチル－６－ノニルシクロヘキサ－２，５－ジエン－１，４－ジオン |
| US11584728B2 (en) | 2019-10-04 | 2023-02-21 | Stealth Biotherapeutics Inc. | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia |
| US12037350B2 (en) | 2020-04-03 | 2024-07-16 | Stealth Biotherapeutics Inc. | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia |
| JP2024525232A (ja) | 2021-07-08 | 2024-07-10 | ピーティーシー セラピューティクス、インコーポレイテッド | ２，３，５－トリメチル－６－ノニルシクロヘキサ－２，５－ジエン－１，４－ジオンを含む医薬組成物 |
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