BR112012014490A2 - processo para a preparação substituída de 1-o-acil-2-desóxi-2-fluoro-4-tio-beta-d-arabinofuranoses - Google Patents
processo para a preparação substituída de 1-o-acil-2-desóxi-2-fluoro-4-tio-beta-d-arabinofuranosesInfo
- Publication number
- BR112012014490A2 BR112012014490A2 BR112012014490A BR112012014490A BR112012014490A2 BR 112012014490 A2 BR112012014490 A2 BR 112012014490A2 BR 112012014490 A BR112012014490 A BR 112012014490A BR 112012014490 A BR112012014490 A BR 112012014490A BR 112012014490 A2 BR112012014490 A2 BR 112012014490A2
- Authority
- BR
- Brazil
- Prior art keywords
- arabinofuranoses
- deoxy
- thio
- fluoro
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09075563 | 2009-12-18 | ||
| EP09075563.8 | 2009-12-18 | ||
| EP10163406.1 | 2010-05-20 | ||
| EP10163406A EP2388257A1 (en) | 2010-05-20 | 2010-05-20 | Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses |
| PCT/JP2010/072182 WO2011074484A1 (en) | 2009-12-18 | 2010-12-03 | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012014490A2 true BR112012014490A2 (pt) | 2015-09-15 |
| BR112012014490B1 BR112012014490B1 (pt) | 2021-07-13 |
Family
ID=43587023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012014490-1A BR112012014490B1 (pt) | 2009-12-18 | 2010-12-03 | Processos para a preparação de 1-o-acil-2-desóxi-2-fluoro-4-tio-?-d-arabinofuranoses e compostos intermediários dos mesmos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8329925B2 (pt) |
| EP (2) | EP2513081B1 (pt) |
| JP (1) | JP5616968B2 (pt) |
| KR (1) | KR101814549B1 (pt) |
| CN (1) | CN102656154B (pt) |
| AU (1) | AU2010331367B2 (pt) |
| BR (1) | BR112012014490B1 (pt) |
| CA (1) | CA2784399C (pt) |
| IL (1) | IL220357A (pt) |
| MX (1) | MX2012006872A (pt) |
| MY (1) | MY156954A (pt) |
| NZ (1) | NZ601222A (pt) |
| RU (1) | RU2559364C2 (pt) |
| SG (1) | SG181745A1 (pt) |
| TW (1) | TWI476204B (pt) |
| WO (1) | WO2011074484A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170082650A (ko) | 2012-03-28 | 2017-07-14 | 후지필름 가부시키가이샤 | 1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염 |
| CN103450148B (zh) * | 2012-06-04 | 2018-06-12 | 浙江九洲药业股份有限公司 | 一种五元环硫酸酯化合物的合成方法 |
| PT2883866T (pt) * | 2012-08-13 | 2019-04-05 | Fujifilm Corp | Intermediário para a síntese de 1-(2-desoxi-2-fluoro-4-tiobeta-d-arabinofuranosilo)citosina, intermediário para a síntese de tionucleósido e métodos para a produção destes intermediários |
| CN103012386B (zh) * | 2012-12-26 | 2015-04-01 | 浙江普洛得邦制药有限公司 | 一种五元环状硫酸酯的制备方法 |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6175553B2 (ja) * | 2014-02-18 | 2017-08-09 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| JP6245527B2 (ja) * | 2014-03-24 | 2017-12-13 | 富士フイルム株式会社 | チオラン環もしくはチアン環骨格を有する化合物の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| JP6450356B2 (ja) | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
| CN109641009B (zh) | 2016-08-31 | 2021-12-31 | 富士胶片株式会社 | 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒 |
| CN106810541A (zh) * | 2016-12-30 | 2017-06-09 | 苏州诚和医药化学有限公司 | 一种一步法制备索非布韦中间体的方法 |
| JP2017214422A (ja) * | 2017-09-01 | 2017-12-07 | 富士フイルム株式会社 | サラシノールの製造に有用な化合物およびそれらの製造法、サラシノールの製造法、ジオール基の保護方法および脱保護方法、並びにジオール基の保護剤 |
| AU2018404329B2 (en) | 2018-01-29 | 2021-09-09 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| EP3766502A4 (en) | 2018-03-13 | 2021-05-05 | FUJIFILM Corporation | ANTITUMOR DRUG, ANTITUMOR ENHANCER AND ANTITUMOR KIT |
| WO2023008511A1 (ja) | 2021-07-29 | 2023-02-02 | 富士フイルム株式会社 | Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4808272A (en) * | 1986-06-20 | 1989-02-28 | Spalding & Evenflo Companies, Inc. | Method of constructing a mold for making game balls |
| US4803272A (en) * | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
| US5602268A (en) | 1995-07-20 | 1997-02-11 | Mallinckrodt Medical, Inc. | Process for producing tungsten clusters |
| ATE224909T1 (de) | 1996-04-09 | 2002-10-15 | Yamasa Corp | 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine |
| WO1997037993A1 (fr) | 1996-04-09 | 1997-10-16 | Yamasa Corporation | DERIVES DE 9-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)PURINE |
| KR100426030B1 (ko) | 2000-07-22 | 2004-04-03 | (주) 한켐 | 락톤계 당화합물에서의 키랄성 전환방법 |
| US20090069263A1 (en) | 2005-12-16 | 2009-03-12 | Damha Masad J | 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof |
-
2010
- 2010-12-03 JP JP2012527135A patent/JP5616968B2/ja active Active
- 2010-12-03 MX MX2012006872A patent/MX2012006872A/es active IP Right Grant
- 2010-12-03 EP EP10801279.0A patent/EP2513081B1/en active Active
- 2010-12-03 KR KR1020127018741A patent/KR101814549B1/ko active IP Right Grant
- 2010-12-03 BR BR112012014490-1A patent/BR112012014490B1/pt active IP Right Grant
- 2010-12-03 RU RU2012130422/04A patent/RU2559364C2/ru active
- 2010-12-03 SG SG2012044368A patent/SG181745A1/en unknown
- 2010-12-03 NZ NZ601222A patent/NZ601222A/xx unknown
- 2010-12-03 AU AU2010331367A patent/AU2010331367B2/en active Active
- 2010-12-03 CA CA2784399A patent/CA2784399C/en active Active
- 2010-12-03 WO PCT/JP2010/072182 patent/WO2011074484A1/en active Application Filing
- 2010-12-03 CN CN201080057198.7A patent/CN102656154B/zh active Active
- 2010-12-03 MY MYPI2012002695A patent/MY156954A/en unknown
- 2010-12-03 EP EP14177042.0A patent/EP2799432B1/en active Active
- 2010-12-03 US US12/959,735 patent/US8329925B2/en active Active
- 2010-12-03 TW TW099142198A patent/TWI476204B/zh active
-
2012
- 2012-06-13 IL IL220357A patent/IL220357A/en active IP Right Grant
- 2012-09-07 US US13/606,746 patent/US8420831B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL220357A0 (en) | 2012-08-30 |
| RU2012130422A (ru) | 2014-01-27 |
| US8329925B2 (en) | 2012-12-11 |
| AU2010331367A2 (en) | 2013-01-24 |
| JP2013514260A (ja) | 2013-04-25 |
| MX2012006872A (es) | 2012-09-12 |
| WO2011074484A1 (en) | 2011-06-23 |
| AU2010331367A1 (en) | 2012-08-02 |
| CN102656154A (zh) | 2012-09-05 |
| EP2799432A1 (en) | 2014-11-05 |
| IL220357A (en) | 2015-11-30 |
| EP2513081B1 (en) | 2015-07-08 |
| RU2559364C2 (ru) | 2015-08-10 |
| KR20120096088A (ko) | 2012-08-29 |
| BR112012014490B1 (pt) | 2021-07-13 |
| US8420831B2 (en) | 2013-04-16 |
| CA2784399A1 (en) | 2011-06-23 |
| US20130005991A1 (en) | 2013-01-03 |
| JP5616968B2 (ja) | 2014-10-29 |
| SG181745A1 (en) | 2012-07-30 |
| US20110152542A1 (en) | 2011-06-23 |
| EP2513081A1 (en) | 2012-10-24 |
| TW201121987A (en) | 2011-07-01 |
| MY156954A (en) | 2016-04-15 |
| CA2784399C (en) | 2018-01-02 |
| AU2010331367B2 (en) | 2017-04-20 |
| KR101814549B1 (ko) | 2018-01-04 |
| NZ601222A (en) | 2013-09-27 |
| EP2799432B1 (en) | 2016-09-21 |
| CN102656154B (zh) | 2014-04-09 |
| TWI476204B (zh) | 2015-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 317/18 , C07D 333/32 , C07D 333/78 Ipc: C07D 317/18 (2006.01), C07D 333/32 (2006.01), C07D |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/12/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |