ATE224909T1 - 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine - Google Patents

1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Info

Publication number
ATE224909T1
ATE224909T1 AT97916633T AT97916633T ATE224909T1 AT E224909 T1 ATE224909 T1 AT E224909T1 AT 97916633 T AT97916633 T AT 97916633T AT 97916633 T AT97916633 T AT 97916633T AT E224909 T1 ATE224909 T1 AT E224909T1
Authority
AT
Austria
Prior art keywords
arabinofuranosyl
deoxy
thio
fluoro
beta
Prior art date
Application number
AT97916633T
Other languages
English (en)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE224909T1 publication Critical patent/ATE224909T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
AT97916633T 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine ATE224909T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (fr) 1996-04-09 1997-04-09 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (1)

Publication Number Publication Date
ATE224909T1 true ATE224909T1 (de) 2002-10-15

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97916633T ATE224909T1 (de) 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Country Status (10)

Country Link
US (1) US6147058A (de)
EP (1) EP0841344B1 (de)
JP (1) JP3657008B2 (de)
AT (1) ATE224909T1 (de)
CA (1) CA2224155C (de)
DE (1) DE69715774T2 (de)
DK (1) DK0841344T3 (de)
ES (1) ES2182061T3 (de)
PT (1) PT841344E (de)
WO (1) WO1997038001A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EP1058686B1 (de) * 1998-02-25 2006-11-02 Emory University 2'-fluoronukleoside
AU2004274021B2 (en) * 2003-09-18 2009-08-13 Isis Pharmaceuticals, Inc. 4'-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
MX2012006872A (es) 2009-12-18 2012-09-12 Libramedicina Inc Proceso para preparar 1-o-acil-2-deoxi-2-fluoro-4-tio-beta-d-arabi nofuranosas sustituidas.
EP2388257A1 (de) 2010-05-20 2011-11-23 LibraMedicina, Inc. Verfahren zur Herstellung von substituierten 1-O-acyl-2-deoxy-2-fluor-4-thio-ß-D-Arabinfuranosen
TWI637963B (zh) 2012-03-28 2018-10-11 富士軟片股份有限公司 １－（２－脫氧－２－氟－４－硫－β－Ｄ－阿拉伯呋喃糖基）胞嘧啶之鹽
AU2013303534B2 (en) 2012-08-13 2016-06-30 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
EP3004130B1 (de) * 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thionukleoside zur behandlung von hcv
CN106061959B (zh) * 2014-02-18 2018-11-09 富士胶片株式会社 四氢噻吩骨架型糖化合物的制造方法及四氢噻吩骨架型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
WO2016155593A1 (zh) * 2015-04-03 2016-10-06 四川科伦药物研究院有限公司 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
CN109641009B (zh) 2016-08-31 2021-12-31 富士胶片株式会社 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒
JP2020502043A (ja) 2016-12-22 2020-01-23 シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド ４’−チオ−２’−フルオロヌクレオシドホスファミド化合物の固体形態及びそのための調製方法及びその使用
WO2019042226A1 (zh) * 2017-09-01 2019-03-07 四川科伦博泰生物医药股份有限公司 用于肿瘤治疗或预防的药物组合物、方法及其用途
AU2018404329B2 (en) 2018-01-29 2021-09-09 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
TW201932120A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 用於具有異檸檬酸脫氫酶突變的腫瘤的藥物組成物與抗腫瘤劑及其應用
TW202000207A (zh) * 2018-02-26 2020-01-01 日商富士軟片股份有限公司 膀胱癌用抗腫瘤劑及膀胱癌的處置方法
CA3093794C (en) 2018-03-13 2023-03-14 Fujifilm Corporation Antitumor enhancer agent comprising 1-(2-deoxy-2-fluoro-4-thio-b-d-arabinofuranosyl)cytosine and an antitumor platinum complex
CN112770731A (zh) * 2018-11-28 2021-05-07 四川科伦博泰生物医药股份有限公司 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
JP2022542697A (ja) * 2019-07-30 2022-10-06 ピノットバイオ，インコーポレイテッド 癌治療用ジヌクレオチド化合物及びその医薬用途
WO2023008511A1 (ja) 2021-07-29 2023-02-02 富士フイルム株式会社 Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
EP0770621A4 (de) * 1994-07-12 1998-01-28 Yamasa Corp 2'-deoxy-2'(substituiertes oder unsubstituiertes methylidene)-4-thionukleosid
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
DE69715774T2 (de) 2003-05-15
JP3657008B2 (ja) 2005-06-08
ES2182061T3 (es) 2003-03-01
WO1997038001A1 (fr) 1997-10-16
DK0841344T3 (da) 2002-12-23
EP0841344A4 (de) 1998-05-13
CA2224155C (en) 2004-10-26
EP0841344B1 (de) 2002-09-25
PT841344E (pt) 2003-02-28
DE69715774D1 (de) 2002-10-31
CA2224155A1 (en) 1997-10-16
EP0841344A1 (de) 1998-05-13
US6147058A (en) 2000-11-14

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